Search Results - "Casimir, A"

Beginnings of Artificial Intelligence in Medicine (AIM): Computational Artifice Assisting Scientific Inquiry and Clinical Art – with Reflections on Present AIM Challenges by Kulikowski, Casimir A.

“…Summary Background : The rise of biomedical expert heuristic knowledge-based approaches for computational modeling and problem solving, for scientific inquiry…”
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Pandemics: Historically Slow “Learning Curve” Leading to Biomedical Informatics and Vaccine Breakthroughs by Kulikowski, Casimir A.

“…Summary Background : The worldwide tragedy of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic vividly demonstrates just how…”
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Ethics in the History of Medical Informatics for Decision-Making: Early Challenges to Digital Health Goals by Kulikowski, Casimir A.

“…Summary Background : Inclusive digital health prioritizes public engagement through digital literacies and internet/web connectivity for advancing and scaling…”
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The paradox of tPA in ischemic stroke: tPA knockdown following recanalization improves functional and histological outcomes by Challa, Siva Reddy, Nalamolu, Koteswara Rao, Fornal, Casimir A., Baker, Isidra M., Mohandass, Adithya, Mada, Sahil Reddy, Wang, Billy C., Pinson, David M., Lahoti, Sourabh, Klopfenstein, Jeffrey D., Veeravalli, Krishna Kumar

“…Previous studies have demonstrated that endogenous tissue-type plasminogen activator (tPA) is upregulated in the brain after an acute ischemic stroke (AIS)…”
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Early Postnatal Manganese Exposure Reduces Rat Cortical and Striatal Biogenic Amine Activity in Adulthood by Lasley, Stephen M, Fornal, Casimir A, Mandal, Shyamali, Strupp, Barbara J, Beaudin, Stephane A, Smith, Donald R

“…Abstract Growing evidence from studies with children and animal models suggests that elevated levels of manganese during early development lead to lasting…”
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Early postnatal manganese exposure causes arousal dysregulation and lasting hypofunctioning of the prefrontal cortex catecholaminergic systems by Conley, Travis E., Beaudin, Stephane A., Lasley, Stephen M., Fornal, Casimir A., Hartman, Jasenia, Uribe, Walter, Khan, Tooba, Strupp, Barbara J., Smith, Donald R.

“…Studies have reported associations between environmental manganese (Mn) exposure and impaired cognition, attention, impulse control, and fine motor function in…”
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The effect of immediate breast reconstruction on the timing of adjuvant chemotherapy: a systematic review by Xavier Harmeling, J., Kouwenberg, Casimir A. E., Bijlard, Eveline, Burger, Koert N. J., Jager, Agnes, Mureau, Marc A. M.

“…Adjuvant chemotherapy is often needed to achieve adequate breast cancer control. The increasing popularity of immediate breast reconstruction (IBR) raises…”
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Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration by Challa, Siva Reddy, Nalamolu, Koteswara Rao, Fornal, Casimir A, Wang, Billy C, Martin, Ryan C, Olson, Elsa A, Ujjainwala, Ammar L, Pinson, David M, Klopfenstein, Jeffrey D, Veeravalli, Krishna Kumar

“…We recently showed that the post-ischemic induction of matrix metalloproteinase-12 (MMP-12) in the brain degrades tight junction proteins, increases MMP-9 and…”
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Long-Term Health-Related Quality of Life after Four Common Surgical Treatment Options for Breast Cancer and the Effect of Complications: A Retrospective Patient-Reported Survey among 1871 Patients by Kouwenberg, Casimir A. E., de Ligt, Kelly M., Kranenburg, Leonieke W., Rakhorst, Hinne, de Leeuw, Daniëlle, Siesling, Sabine, Busschbach, Jan J., Mureau, Marc A. M.

“…Differences in quality-of-life outcomes after different surgical breast cancer treatment options, including breast reconstruction, are relevant for counseling…”
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Donald A. B. Lindberg: Inspiring Leader and Visionary in Biomedicine, Healthcare, and Informatics by Kulikowski, Casimir A.

“…Summary Background: As Director of the US National Library of Medicine (NLM) for 30 years, Dr. Donald A. B. Lindberg was instrumental in bringing biomedical…”
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The interplay between MMP-12 and t-PA in the brain after ischemic stroke by Challa, Siva Reddy, Nalamolu, Koteswara Rao, Fornal, Casimir A., Mohandass, Adithya, Mussman, Justin P., Schaibley, Claire, Kashyap, Aanan, Sama, Vinay, Wang, Billy C., Klopfenstein, Jeffrey D., Pinson, David M., Kunamneni, Adinarayana, Veeravalli, Krishna Kumar

“…Tissue-type plasminogen activator (t-PA) expression is known to increase following transient focal cerebral ischemia and reperfusion. Previously, we reported…”
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Why Breast-Conserving Therapy Should be Considered Treatment of Choice in Early-Stage Breast Cancer Patients by Kouwenberg, Casimir A. E., Kranenburg, Leonieke W., Busschbach, Jan J., Mureau, Marc A. M.

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A method for exploring implicit concept relatedness in biomedical knowledge network by Bai, Tian, Gong, Leiguang, Wang, Ye, Wang, Yan, Kulikowski, Casimir A, Huang, Lan

“…Biomedical information and knowledge, structural and non-structural, stored in different repositories can be semantically connected to form a hybrid knowledge…”
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Burden of Keloid Disease: A Cross-sectional Health-related Quality of Life Assessment by Bijlard, Eveline, Kouwenberg, Casimir A E, Timman, Reinier, Hovius, Steven E R, Busschbach, Jan J V, Mureau, Marc A M

“…Keloid scars may be painful, itch severely and be cosmetically disturbing. The burden of keloid disease, however, has not yet been determined. This study…”
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A Scoping Review on the Progress, Applicability, and Future of Explainable Artificial Intelligence in Medicine by González-Alday, Raquel, García-Cuesta, Esteban, Kulikowski, Casimir A, Maojo, Victor

“…Due to the success of artificial intelligence (AI) applications in the medical field over the past decade, concerns about the explainability of these systems…”
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Attenuation of the Induction of TLRs 2 and 4 Mitigates Inflammation and Promotes Neurological Recovery After Focal Cerebral Ischemia by Nalamolu, Koteswara Rao, Challa, Siva Reddy, Fornal, Casimir A., Grudzien, Natalia A., Jorgenson, Laura C., Choudry, Mouneeb M., Smith, Nathan J., Palmer, Cassandra J., Pinson, David M., Klopfenstein, Jeffrey D., Veeravalli, Krishna Kumar

“…The intense inflammatory response triggered in the brain after focal cerebral ischemia is detrimental. Recently, we showed that the suppression of toll-like…”
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Oral methylphenidate alleviates the fine motor dysfunction caused by chronic postnatal manganese exposure in adult rats by Beaudin, Stéphane A, Strupp, Barbara J, Lasley, Stephen M, Fornal, Casimir A, Mandal, Shyamali, Smith, Donald R

“…Developmental manganese (Mn) exposure is associated with motor dysfunction in children and animal models, but little is known about the underlying…”
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AMIA Board white paper: definition of biomedical informatics and specification of core competencies for graduate education in the discipline by Kulikowski, Casimir A, Shortliffe, Edward H, Currie, Leanne M, Elkin, Peter L, Hunter, Lawrence E, Johnson, Todd R, Kalet, Ira J, Lenert, Leslie A, Musen, Mark A, Ozbolt, Judy G, Smith, Jack W, Tarczy-Hornoch, Peter Z, Williamson, Jeffrey J

“…The AMIA biomedical informatics (BMI) core competencies have been designed to support and guide graduate education in BMI, the core scientific discipline…”
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Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats by Nalamolu, Koteswara Rao, Chelluboina, Bharath, Fornal, Casimir A, Challa, Siva Reddy, Pinson, David M, Wang, David Z, Klopfenstein, Jeffrey D, Veeravalli, Krishna Kumar

“…Background and purposeThe therapeutic potential of different stem cells for ischaemic stroke treatment is intriguing and somewhat controversial. Recent results…”
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The Impact of Social Isolation and Environmental Deprivation on Blood Pressure and Depression-Like Behavior in Young Male and Female Mice by Challa, Siva Reddy, Fornal, Casimir A., Wang, Billy C., Boyineni, Jerusha, DeVera, Roberto E., Unnam, Pavani, Song, Yajing, Soares, Marcelo Bento, Malchenko, Sergey, Gyarmati, Peter, Veeravalli, Krishna Kumar

“…Background: Social isolation (SI) and loneliness are major adult and adolescent health concerns, particularly in the coronavirus disease 2019 (COVID-19) era…”
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