Search Results - "Casillas, Andrea L."

PIM kinases alter mitochondrial dynamics and chemosensitivity in lung cancer by Chauhan, Shailender S., Toth, Rachel K., Jensen, Corbin C., Casillas, Andrea L., Kashatus, David F., Warfel, Noel A.

“…Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small-cell lung cancer (NSCLC). The goal of this study was to…”
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Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents by Casillas, Andrea L, Toth, Rachel K, Sainz, Alva G, Singh, Neha, Desai, Ankit A, Kraft, Andrew S, Warfel, Noel A

“…Patients develop resistance to antiangiogenic drugs, secondary to changes in the tumor microenvironment, including hypoxia. PIM kinases are prosurvival kinases…”
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Direct phosphorylation and stabilization of HIF-1α by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Sainz, Alva G., Clements, Amber N., Jensen, Corbin C., Langlais, Paul R., Miranti, Cindy K., Cress, Anne E., Warfel, Noel A.

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
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PIM1 drives lipid droplet accumulation to promote proliferation and survival in prostate cancer by Chauhan, Shailender S., Casillas, Andrea L., Vizzerra, Andres D., Liou, Hope, Clements, Amber N., Flores, Caitlyn E., Prevost, Christopher T., Kashatus, David F., Snider, Ashley J., Snider, Justin M., Warfel, Noel A.

“…Lipid droplets (LDs) are dynamic organelles with a neutral lipid core surrounded by a phospholipid monolayer. Solid tumors exhibit LD accumulation, and it is…”
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PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion by Jensen, Corbin C, Clements, Amber N, Liou, Hope, Ball, Lauren E, Bethard, Jennifer R, Langlais, Paul R, Toth, Rachel K, Chauhan, Shailender S, Casillas, Andrea L, Daulat, Sohail R, Kraft, Andrew S, Cress, Anne E, Miranti, Cindy K, Mouneimne, Ghassan, Rogers, Greg C, Warfel, Noel A

“…Distinguishing key factors that drive the switch from indolent to invasive disease will make a significant impact on guiding the treatment of prostate cancer…”
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Bioengineering approaches to improve gynecological cancer outcomes by Abbaspour, Ali, Casillas, Andrea L., McGregor, Stephanie M., Kreeger, Pamela K.

“…Gynecological cancers are diagnosed in over a million females worldwide, with ovarian, endometrial (uterine), and cervical the most common. Here, we highlight…”
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Abstract 1482: PIM1 promotes angiogenesis via phosphorylation and stabilization of HIF-1α by Casillas, Andrea L., Chauhan, Shailender S., Toth, Rachel K., Jensen, Corbin C., Warfel, Noel A.

“…Abstract An essential process for the growth and dissemination of solid tumors is angiogenesis, or the formation of new blood vessels. Overexpression of…”
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Abstract 6332: Pim kinase inhibition promotes mitochondrial fission to combat chemoresistance in non-small cell lung cancer by Chauhan, Shailender S., Toth, Rachel K., Jensen, Corbin C., Kashatus, David F., Casillas, Andrea L., Warfel, Noel A.

“…Abstract Background: Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small cell lung cancer (NSCLC). A fused…”
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Direct phosphorylation and stabilization of HIF-1[alpha] by PIM1 kinase drives angiogenesis in solid tumors by Casillas, Andrea L, Chauhan, Shailender S, Toth, Rachel K, Sainz, Alva G, Clements, Amber N, Jensen, Corbin C, Langlais, Paul R, Miranti, Cindy K, Cress, Anne E, Warfel, Noel A

“…Angiogenesis is essential for the sustained growth of solid tumors. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of angiogenesis and constitutive…”
Get full text

Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents by Casillas, Andrea L., Toth, Rachel K., Sainz, Alva G., Singh, Neha, Desai, Ankit A., Kraft, Andrew S., Warfel, Noel A.

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Defining the Role of PIM1 in Tumor Angiogenesis by Casillas, Andrea L

“…PIM1 is a serine/threonine kinase that is upregulated in cancer. PIM1 is constitutively active upon translation, so protein levels equate to activity…”
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