Search Results - "Cash, Jennifer N."

High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines by Li, Yilai, Cash, Jennifer N., Tesmer, John J.G., Cianfrocco, Michael A.

“…Single-particle cryoelectron microscopy (cryo-EM) continues to grow into a mainstream structural biology technique. Recent developments in data collection…”
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Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma by Lu, Tsan-Wen, Aoto, Phillip C, Weng, Jui-Hung, Nielsen, Cole, Cash, Jennifer N, Hall, James, Zhang, Ping, Simon, Sanford M, Cianfrocco, Michael A, Taylor, Susan S

“…When the J-domain of the heat shock protein DnaJB1 is fused to the catalytic (C) subunit of cAMP-dependent protein kinase (PKA), replacing exon 1, this fusion…”
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Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3 by Cash, Jennifer N., Davis, Ellen M., Tesmer, John J.G.

“…Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine nucleotide exchange factor synergistically activated by…”
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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
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High-resolution cryo-EM using beam-image shift at 200 keV by Cash, Jennifer N, Kearns, Sarah, Li, Yilai, Cianfrocco, Michael A

“…Recent advances in single-particle cryo-electron microscopy (cryo-EM) data collection utilize beam-image shift to improve throughput. Despite implementation on…”
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Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold by Cash, Jennifer N, Urata, Sarah, Li, Sheng, Ravala, Sandeep K, Avramova, Larisa V, Shost, Michael D, Gutkind, J Silvio, Tesmer, John J G, Cianfrocco, Michael A

“…PIP -dependent Rac exchanger 1 (P-Rex1) is activated downstream of G protein-coupled receptors to promote neutrophil migration and metastasis. The structure of…”
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Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP3 by Cash, Jennifer N., Sharma, Prateek V., Tesmer, John J.G.

“…[Display omitted] •The crystal structure of the P-Rex2 PH domain was determined to 1.9 Å.•In comparison to the P-Rex1 PH, the β5/β6 loop conformation is the…”
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New insights into regulation of P‐Rex1 autoinhibition by Ravala, Sandeep Kaur, Li, Sheng, Chen, Chun‐Liang, Cianfrocco, Michael A., Cash, Jennifer N., Tesmer, John J. G.

“…Phosphatidylinositol 3,4,5‐trisphosphate (PIP3)–dependent Rac exchanger 1 (P‐Rex1) is a guanine nucleotide exchange factor for Rho GTPases downstream of G…”
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Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1 by Bandekar, Sumit J., Chen, Chun-Liang, Ravala, Sandeep K., Cash, Jennifer N., Avramova, Larisa V., Zhalnina, Mariya V., Gutkind, J. Silvio, Li, Sheng, Tesmer, John J.G.

“…Trio is a large and highly conserved metazoan signaling scaffold that contains two Dbl family guanine nucleotide exchange factor (GEF) modules, TrioN and…”
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The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding by Ravala, Sandeep K., Hopkins, Jesse B., Plescia, Caroline B., Allgood, Samantha R., Kane, Madison A., Cash, Jennifer N., Stahelin, Robert V., Tesmer, John J.G.

“…Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) catalyzes the exchange of GDP for GTP on Rac GTPases, thereby triggering…”
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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils by Cash, Jennifer N., Chandan, Naincy R., Hsu, Alan Y., Sharma, Prateek V., Deng, Qing, Smrcka, Alan V., Tesmer, John J.G.

“…Phosphatidylinositol (3,4,5) trisphosphate (PIP 3 )-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally…”
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The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding by Cash, Jennifer N, Rejon, Carlis A, McPherron, Alexandra C, Bernard, Daniel J, Thompson, Thomas B

“…Myostatin is a member of the transforming growth factor‐β (TGF‐β) family and a strong negative regulator of muscle growth. Here, we present the crystal…”
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Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding by Cash, Jennifer N, Angerman, Elizabeth B, Kattamuri, Chandramohan, Nolan, Kristof, Zhao, Huaying, Sidis, Yisrael, Keutmann, Henry T, Thompson, Thomas B

“…TGF-β family ligands are involved in a variety of critical physiological processes. For instance, the TGF-β ligand myostatin is a staunch negative regulator of…”
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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP 3 )-Dependent Rac Exchanger 1 (P-Rex1) PIP 3 -Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils by Cash, Jennifer N, Chandan, Naincy R, Hsu, Alan Y, Sharma, Prateek V, Deng, Qing, Smrcka, Alan V, Tesmer, John J G

“…Phosphatidylinositol (3,4,5) trisphosphate (PIP )-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally discovered…”
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Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism by Cash, Jennifer N, Angerman, Elizabeth B, Keutmann, Henry T, Thompson, Thomas B

“…Follistatin (FST)-type proteins are important antagonists of some members of the large TGF-β family of cytokines. These include myostatin, an important…”
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Development of a small-molecule screening method for inhibitors of cellular response to myostatin and activin A by Cash, Jennifer N, Angerman, Elizabeth B, Kirby, R Jason, Merck, Lisa, Seibel, William L, Wortman, Matthew D, Papoian, Ruben, Nelson, Sandra, Thompson, Thomas B

“…Myostatin, a member of the transforming growth factor (TGF)-β family of secreted ligands, is a strong negative regulator of muscle growth. As such, therapeutic…”
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Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4 by Ravala, Sandeep K, Adame-Garcia, Sendi Rafael, Li, Sheng, Chen, Chun-Liang, Cianfrocco, Michael A, Silvio Gutkind, J, Cash, Jennifer N, Tesmer, John JG

“…PIP 3 -dependent Rac exchanger 1 (P-Rex1) is abundantly expressed in neutrophils and plays central roles in chemotaxis and cancer metastasis by serving as a…”
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Structural and Functional Characterization of the Metastatic RhoGEF P‐Rex1 and its Regulation by PtdIns(3,4,5) P 3 : Towards Inhibitory Small Molecule Development by Cash, Jennifer N., Davis, Ellen M., Tesmer, John J.G.

“…Abstract only Phosphatidylinositol 3,4,5‐trisphosphate (PIP 3 )‐dependent Rac exchanger 1 (P‐Rex1) is a Rho guanine‐nucleotide exchange factor (RhoGEF) that…”
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Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P[subscript 3] by Cash, Jennifer N., Davis, Ellen M., Tesmer, John J.G.

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Discovery and Assessment of Chemical Probes Targeting Regulatory Surfaces of P‐Rex1, a Metastatic RhoGEF by Cash, Jennifer N, Sharma, Prateek, Shost, Michael, Davis, Ellen, Tesmer, John

“…Abstract only Phosphatidylinositol 3,4,5‐trisphosphate (PIP 3 )‐dependent Rac exchanger 1 (P‐Rex1) is a Rho guanine‐nucleotide exchange factor (RhoGEF) that…”
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