Search Results - "Casey, Michael E."
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Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation-maximization reconstruction
Published in Physics in medicine & biology (07-08-2016)“…Whole-body (WB) dynamic PET has recently demonstrated its potential in translating the quantitative benefits of parametric imaging to the clinic…”
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Generalized whole-body Patlak parametric imaging for enhanced quantification in clinical PET
Published in Physics in medicine & biology (21-11-2015)“…We recently developed a dynamic multi-bed PET data acquisition framework to translate the quantitative benefits of Patlak voxel-wise analysis to the domain of…”
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Impact of Time-of-Flight on PET Tumor Detection
Published in Journal of Nuclear Medicine (01-08-2009)“…Time-of-flight (TOF) PET uses very fast detectors to improve localization of events along coincidence lines-of-response. This information is then utilized to…”
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Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Published in Physics in medicine & biology (08-03-2019)“…PET has the potential to perform absolute in vivo radiotracer quantitation. This potential can be compromised by voluntary body motion (BM), which degrades…”
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Validation of the SimSET simulation package for modeling the Siemens Biograph mCT PET scanner
Published in Physics in medicine & biology (07-02-2015)“…Monte Carlo simulation provides a valuable tool in performance assessment and optimization of system design parameters for PET scanners. SimSET is a popular…”
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Spatiotemporal distribution modeling of PET tracer uptake in solid tumors
Published in Annals of nuclear medicine (01-02-2017)“…Objective Distribution of PET tracer uptake is elaborately modeled via a general equation used for solute transport modeling. This model can be used to…”
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Dynamic whole-body PET imaging: principles, potentials and applications
Published in European journal of nuclear medicine and molecular imaging (01-02-2019)“…Purpose In this article, we discuss dynamic whole-body (DWB) positron emission tomography (PET) as an imaging tool with significant clinical potential, in…”
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Benefit of Improved Performance with State-of-the Art Digital PET/CT for Lesion Detection in Oncology
Published in Journal of Nuclear Medicine (01-11-2020)“…The latest digital whole-body PET scanners provide a combination of higher sensitivity and improved spatial and timing resolution. We performed a lesion…”
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Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data
Published in Journal of Nuclear Medicine (01-09-2018)“…Respiratory motion degrades the detection and quantification capabilities of PET/CT imaging. Moreover, mismatch between a fast helical CT image and a…”
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A multi-centre evaluation of eleven clinically feasible brain PET/MRI attenuation correction techniques using a large cohort of patients
Published in NeuroImage (Orlando, Fla.) (15-02-2017)“…To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal…”
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Unsupervised inter-frame motion correction for whole-body dynamic PET using convolutional long short-term memory in a convolutional neural network
Published in Medical image analysis (01-08-2022)“…Subject motion in whole-body dynamic PET introduces inter-frame mismatch and seriously impacts parametric imaging. Traditional non-rigid registration methods…”
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Motion correction strategies for integrated PET/MR
Published in Journal of Nuclear Medicine (01-02-2015)“…Integrated whole-body PET/MR facilitates the implementation of a broad variety of respiratory motion correction strategies, taking advantage of the strengths…”
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Simultaneous reconstruction of the activity image and registration of the CT image in TOF-PET
Published in Physics in medicine & biology (21-02-2016)“…Previously, maximum-likelihood methods have been proposed to jointly estimate the activity image and the attenuation image or the attenuation sinogram from…”
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Feasibility of using abbreviated scan protocols with population-based input functions for accurate kinetic modeling of [18F]-FDG datasets from a long axial FOV PET scanner
Published in European journal of nuclear medicine and molecular imaging (01-01-2023)“…Background Accurate kinetic modeling of 18F-fluorodeoxyglucose ([ 18 F]-FDG) positron emission tomography (PET) data requires accurate knowledge of the…”
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Development and Evaluation of mini-EXPLORER: A Long Axial Field-of-View PET Scanner for Nonhuman Primate Imaging
Published in Journal of Nuclear Medicine (01-06-2018)“…We describe a long axial field-of-view (FOV) PET scanner for high-sensitivity and total-body imaging of nonhuman primates and present the physical performance…”
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Generalized PSF modeling for optimized quantitation in PET imaging
Published in Physics in medicine & biology (21-06-2017)“…Point-spread function (PSF) modeling offers the ability to account for resolution degrading phenomena within the PET image generation framework. PSF modeling…”
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An Assessment of the Impact of Incorporating Time-of-Flight Information into Clinical PET/CT Imaging
Published in Journal of Nuclear Medicine (01-02-2010)“…The introduction of fast scintillators with good stopping power for 511-keV photons has renewed interest in time-of-flight (TOF) PET. The ability to measure…”
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List-mode reconstruction for the Biograph mCT with physics modeling and event-by-event motion correction
Published in Physics in medicine & biology (21-08-2013)“…Whole-body PET/CT scanners are important clinical and research tools to study tracer distribution throughout the body. In whole-body studies, respiratory…”
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Evaluation of MLACF based calculated attenuation brain PET imaging for FDG patient studies
Published in Physics in medicine & biology (07-04-2017)“…Calculating attenuation correction for brain PET imaging rather than using CT presents opportunities for low radiation dose applications such as pediatric…”
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