Search Results - "Case, Roy I"

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle by Eliasof, Scott, Lazarus, Douglas, Peters, Christian G., Case, Roy I., Cole, Roderic O., Hwang, Jungyeon, Schluep, Thomas, Chao, Joseph, Lin, James, Yen, Yun, Han, Han, Wiley, Devin T., Zuckerman, Jonathan E., Davis, Mark E.

“…Nanoparticles are currently being investigated in a number of human clinical trials. As information on how nanoparticles function in humans is difficult to…”
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Discovery of a Novel Cabazitaxel Nanoparticle–Drug Conjugate (CRLX522) with Improved Pharmacokinetic Properties and Anticancer Effects Using a β‑Cyclodextrin–PEG Copolymer Based Delivery Platform by Metcalf, Chester A, Svenson, Sonke, Hwang, Jungyeon, Tripathi, Snehlata, Gangal, Geeti, Kabir, Sujan, Lazarus, Douglas, Cole, Roderic, Sweryda-Krawiec, Beata, Shum, Pochi, Brown, Donna, Case, Roy I, van der Poll, Derek, Rohde, Ellen, Harlfinger, Stephanie, Teng, Chi-Hse, Eliasof, Scott

“…Novel nanoparticle–drug conjugates (NDCs) containing diverse, clinically relevant anticancer drug payloads (docetaxel, cabazitaxel, and gemcitabine) were…”
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Tumor Selective Silencing Using an RNAi-Conjugated Polymeric Nanopharmaceutical by Svenson, Sonke, Case, Roy I, Cole, Roderick O, Hwang, Jungyeon, Kabir, Sujan R, Lazarus, Douglas, Lim Soo, Patrick, Ng, Pei-Sze, Peters, Christian, Shum, Pochi, Sweryda-Krawiec, Beata, Tripathi, Snehlata, van der Poll, Derek, Eliasof, Scott

“…Small interfering RNA (siRNA) therapeutics have potential advantages over traditional small molecule drugs such as high specificity and the ability to inhibit…”
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Abstract 5135: Sustained and controlled in vivo therapeutic levels of drug payloads in tumors using two separate drug combination platforms: Antibody nanoparticle-drug conjugates and multi-drug nanoparticle-drug conjugates, with the potential for improved drug combinability and anticancer effects by Metcalf, Chester A., Poll, Derek van der, Zhao, Liang, Case, Roy I., Lazarus, Doug, Brown, Donna, Halo, Tiffany, Jayaraman, Lata, Peters, Christian, Rohde, Ellen, Eliasof, Scott

“…Abstract Our nanoparticle-drug conjugates (NDCs), created at Cerulean Pharma Inc. by conjugating drug payloads to our novel β-cyclodextrin-PEG (CDP) copolymer,…”
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