Search Results - "Case, James Brett"

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors by Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E, Carter, Lauren, Walls, Alexandra C, Park, Young-Jun, Strauch, Eva-Maria, Stewart, Lance, Diamond, Michael S, Veesler, David, Baker, David

“…Targeting the interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and the human angiotensin-converting enzyme 2…”
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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody by Pinto, Dora, Park, Young-Jun, Beltramello, Martina, Walls, Alexandra C., Tortorici, M. Alejandra, Bianchi, Siro, Jaconi, Stefano, Culap, Katja, Zatta, Fabrizia, De Marco, Anna, Peter, Alessia, Guarino, Barbara, Spreafico, Roberto, Cameroni, Elisabetta, Case, James Brett, Chen, Rita E., Havenar-Daughton, Colin, Snell, Gyorgy, Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Diamond, Michael S., Fink, Katja, Veesler, David, Corti, Davide

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly emerged coronavirus that is responsible for the current pandemic of coronavirus disease…”
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Growth, detection, quantification, and inactivation of SARS-CoV-2 by Case, James Brett, Bailey, Adam L., Kim, Arthur S., Chen, Rita E., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is the agent responsible for the coronavirus disease 2019 (COVID-19) global pandemic. SARS-CoV-2 is…”
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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection by Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.

“…SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials,…”
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A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies by Hassan, Ahmed O., Case, James Brett, Winkler, Emma S., Thackray, Larissa B., Kafai, Natasha M., Bailey, Adam L., McCune, Broc T., Fox, Julie M., Chen, Rita E., Alsoussi, Wafaa B., Turner, Jackson S., Schmitz, Aaron J., Lei, Tingting, Shrihari, Swathi, Keeler, Shamus P., Fremont, Daved H., Greco, Suellen, McCray, Paul B., Perlman, Stanley, Holtzman, Michael J., Ellebedy, Ali H., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of…”
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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease by Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R

“…Emerging coronaviruses (CoVs) cause severe disease in humans, but no approved therapeutics are available. The CoV nsp14 exoribonuclease (ExoN) has complicated…”
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Association between SARS-CoV-2 Neutralizing Antibodies and Commercial Serological Assays by Tang, Mei San, Case, James Brett, Franks, Caroline E, Chen, Rita E, Anderson, Neil W, Henderson, Jeffrey P, Diamond, Michael S, Gronowski, Ann M, Farnsworth, Christopher W

“…Abstract Background Commercially available SARS-CoV-2 serological assays based on different viral antigens have been approved for the qualitative determination…”
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Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2 by Kang, Yuan-Lin, Chou, Yi-ying, Rothlauf, Paul W., Liu, Zhuoming, Soh, Timothy K., Cureton, David, Case, James Brett, Chen, Rita E., Diamond, Michael S., Whelan, Sean P. J., Kirchhausen, Tom

“…Virus entry is a multistep process. It initiates when the virus attaches to the host cell and ends when the viral contents reach the cytosol. Genetically…”
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Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2 by Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Liu, Zhuoming, Zhao, Haiyan, Kim, Arthur S., Bloyet, Louis-Marie, Zeng, Qiru, Tahan, Stephen, Droit, Lindsay, Ilagan, Ma. Xenia G., Tartell, Michael A., Amarasinghe, Gaya, Henderson, Jeffrey P., Miersch, Shane, Ustav, Mart, Sidhu, Sachdev, Virgin, Herbert W., Wang, David, Ding, Siyuan, Corti, Davide, Theel, Elitza S., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.

“…Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and possibly transmission. An anticipated correlate of such countermeasures…”
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Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion by Zang, Ruochen, Case, James Brett, Yutuc, Eylan, Ma, Xiucui, Shen, Sheng, Castro, Maria Florencia Gomez, Liu, Zhuoming, Zeng, Qiru, Zhao, Haiyan, Son, Juhee, Rothlauf, Paul W., Kreutzberger, Alex J. B., Hou, Gaopeng, Zhang, Hu, Bose, Sayantan, Wang, Xin, Vahey, Michael D., Mani, Kartik, Griffiths, William J., Kirchhausen, Tom, Fremont, Daved H., Guo, Haitao, Diwan, Abhinav, Wang, Yuqin, Diamond, Michael S., Whelan, Sean P. J., Ding, Siyuan

“…Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses…”
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Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice by Case, James Brett, Rothlauf, Paul W., Chen, Rita E., Kafai, Natasha M., Fox, Julie M., Smith, Brittany K., Shrihari, Swathi, McCune, Broc T., Harvey, Ian B., Keeler, Shamus P., Bloyet, Louis-Marie, Zhao, Haiyan, Ma, Meisheng, Adams, Lucas J., Winkler, Emma S., Holtzman, Michael J., Fremont, Daved H., Whelan, Sean P.J., Diamond, Michael S.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of human infections, and an effective vaccine is critical to mitigate…”
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SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice by Winkler, Emma S, Chen, Rita E, Alam, Fahmida, Yildiz, Soner, Case, James Brett, Uccellini, Melissa B, Holtzman, Michael J, Garcia-Sastre, Adolfo, Schotsaert, Michael, Diamond, Michael S

“…The development of mouse models for coronavirus disease 2019 (COVID-19) has enabled testing of vaccines and therapeutics and defining aspects of severe acute…”
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Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains by Case, James Brett, Mackin, Samantha, Errico, John M., Chong, Zhenlu, Madden, Emily A., Whitener, Bradley, Guarino, Barbara, Schmid, Michael A., Rosenthal, Kim, Ren, Kuishu, Dang, Ha V., Snell, Gyorgy, Jung, Ana, Droit, Lindsay, Handley, Scott A., Halfmann, Peter J., Kawaoka, Yoshihiro, Crowe, James E., Fremont, Daved H., Virgin, Herbert W., Loo, Yueh-Ming, Esser, Mark T., Purcell, Lisa A., Corti, Davide, Diamond, Michael S.

“…Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro studies have…”
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Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity by Case, James Brett, Li, Yize, Elliott, Ruth, Lu, Xiaotao, Graepel, Kevin W, Sexton, Nicole R, Smith, Everett Clinton, Weiss, Susan R, Denison, Mark R

“…Coronaviruses (CoVs) are positive-sense RNA viruses that infect numerous mammalian and avian species and are capable of causing severe and lethal disease in…”
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques by Hassan, Ahmed O., Feldmann, Friederike, Zhao, Haiyan, Curiel, David T., Okumura, Atsushi, Tang-Huau, Tsing-Lee, Case, James Brett, Meade-White, Kimberly, Callison, Julie, Chen, Rita E., Lovaglio, Jamie, Hanley, Patrick W., Scott, Dana P., Fremont, Daved H., Feldmann, Heinz, Diamond, Michael S.

“…The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently…”
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Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations by Miersch, Shane, Li, Zhijie, Saberianfar, Reza, Ustav, Mart, Brett Case, James, Blazer, Levi, Chen, Chao, Ye, Wei, Pavlenco, Alevtina, Gorelik, Maryna, Garcia Perez, Julia, Subramania, Suryasree, Singh, Serena, Ploder, Lynda, Ganaie, Safder, Chen, Rita E., Leung, Daisy W., Pandolfi, Pier Paolo, Novelli, Giuseppe, Matusali, Giulia, Colavita, Francesca, Capobianchi, Maria R., Jain, Suresh, Gupta, J.B., Amarasinghe, Gaya K., Diamond, Michael S., Rini, James, Sidhu, Sachdev S.

“…[Display omitted] •Rapid isolation of neutralizing antibodies without natural immune repertoires.•Facile re-reformatting to tetravalent antibodies enhances…”
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Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds by Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St, Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark

“…Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display…”
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An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer by Suryadevara, Naveenchandra, Shiakolas, Andrea R, VanBlargan, Laura A, Binshtein, Elad, Chen, Rita E, Case, James Brett, Kramer, Kevin J, Armstrong, Erica C, Myers, Luke, Trivette, Andrew, Gainza, Christopher, Nargi, Rachel S, Selverian, Christopher N, Davidson, Edgar, Doranz, Benjamin J, Diaz, Summer M, Handal, Laura S, Carnahan, Robert H, Diamond, Michael S, Georgiev, Ivelin S, Crowe, Jr, James E

“…The protective human antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the…”
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Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting by Hauser, Blake M., Sangesland, Maya, St. Denis, Kerri J., Lam, Evan C., Case, James Brett, Windsor, Ian W., Feldman, Jared, Caradonna, Timothy M., Kannegieter, Ty, Diamond, Michael S., Balazs, Alejandro B., Lingwood, Daniel, Schmidt, Aaron G.

“…Eliciting antibodies to surface-exposed viral glycoproteins can generate protective responses that control and prevent future infections. Targeting conserved…”
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Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations by Graepel, Kevin W, Lu, Xiaotao, Case, James Brett, Sexton, Nicole R, Smith, Everett Clinton, Denison, Mark R

“…The coronavirus (CoV) RNA genome is the largest among the single-stranded positive-sense RNA viruses. CoVs encode a proofreading 3'-to-5' exoribonuclease…”
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