Search Results - "Cascallò, Manel"

A Phase 1 Trial of Oncolytic Adenovirus ICOVIR-5 Administered Intravenously to Cutaneous and Uveal Melanoma Patients by García, Margarita, Moreno, Rafael, Gil-Martin, Marta, Cascallò, Manel, de Olza, Maria Ochoa, Cuadra, Carmen, Piulats, Josep Maria, Navarro, Valentin, Domenech, Marta, Alemany, Ramon, Salazar, Ramon

“…Oncolytic viruses represent a unique type of agents that combine self-amplification, lytic, and immunostimulatory properties against tumors. A local and…”
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Safety and efficacy of VCN-01, an oncolytic adenovirus combining fiber HSG-binding domain replacement with RGD and hyaluronidase expression by Rodríguez-García, Alba, Giménez-Alejandre, Marta, Rojas, Juan J, Moreno, Rafael, Bazan-Peregrino, Miriam, Cascalló, Manel, Alemany, Ramon

“…Tumor targeting upon intravenous administration and subsequent intratumoral virus dissemination are key features to improve oncolytic adenovirus therapy…”
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Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth by Guedan, Sonia, Rojas, Juan José, Gros, Alena, Mercade, Elena, Cascallo, Manel, Alemany, Ramon

“…Successful virotherapy requires efficient virus spread within tumors. We tested whether the expression of hyaluronidase, an enzyme which dissociates the…”
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Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01 by Pascual-Pasto, Guillem, Bazan-Peregrino, Miriam, Olaciregui, Nagore G, Restrepo-Perdomo, Camilo A, Mato-Berciano, Ana, Ottaviani, Daniela, Weber, Klaus, Correa, Genoveva, Paco, Sonia, Vila-Ubach, Monica, Cuadrado-Vilanova, Maria, Castillo-Ecija, Helena, Botteri, Gaia, Garcia-Gerique, Laura, Moreno-Gilabert, Helena, Gimenez-Alejandre, Marta, Alonso-Lopez, Patricia, Farrera-Sal, Marti, Torres-Manjon, Silvia, Ramos-Lozano, Dolores, Moreno, Rafael, Aerts, Isabelle, Doz, François, Cassoux, Nathalie, Chapeaublanc, Elodie, Torrebadell, Montserrat, Roldan, Monica, König, Andrés, Suñol, Mariona, Claverol, Joana, Lavarino, Cinzia, Carmen de, Torres, Fu, Ligia, Radvanyi, François, Munier, Francis L, Catalá-Mora, Jaume, Mora, Jaume, Alemany, Ramón, Cascalló, Manel, Chantada, Guillermo L, Carcaboso, Angel M

“…Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous inactivation of the tumor suppressor VCN-01 is an oncolytic adenovirus…”
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Phase I, multicenter, open-label study of intravenous VCN-01 oncolytic adenovirus with or without nab-paclitaxel plus gemcitabine in patients with advanced solid tumors by Garcia-Carbonero, Rocio, Bazan-Peregrino, Miriam, Gil-Martín, Marta, Álvarez, Rafael, Macarulla, Teresa, Riesco-Martinez, Maria C, Verdaguer, Helena, Guillén-Ponce, Carmen, Farrera-Sal, Martí, Moreno, Rafael, Mato-Berciano, Ana, Maliandi, Maria Victoria, Torres-Manjon, Silvia, Costa, Marcel, Del Pozo, Natalia, Martínez de Villarreal, Jaime, Real, Francisco X, Vidal, Noemí, Capella, Gabriel, Alemany, Ramon, Blasi, Emma, Blasco, Carmen, Cascalló, Manel, Salazar, Ramon

“…VCN-01 is an oncolytic adenovirus (Ad5 based) designed to replicate in cancer cells with dysfunctional RB1 pathway, express hyaluronidase to enhance virus…”
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A pRb-responsive, RGD-modified, and Hyaluronidase-armed Canine Oncolytic Adenovirus for Application in Veterinary Oncology by Laborda, Eduardo, Puig-Saus, Cristina, Rodriguez-García, Alba, Moreno, Rafael, Cascalló, Manel, Pastor, Josep, Alemany, Ramon

“…Human and canine cancer share similarities such as genetic and molecular aspects, biological complexity, tumor epidemiology, and targeted therapeutic…”
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The Oncolytic Adenovirus VCN-01 as Therapeutic Approach Against Pediatric Osteosarcoma by Martínez-Vélez, Naiara, Xipell, Enric, Vera, Beatriz, Acanda de la Rocha, Arlet, Zalacain, Marta, Marrodán, Lucía, Gonzalez-Huarriz, Marisol, Toledo, Gemma, Cascallo, Manel, Alemany, Ramón, Patiño, Ana, Alonso, Marta M

“…Osteosarcoma is the most common malignant bone tumor in children and adolescents. Despite aggressive chemotherapy, more than 30% of patients do not respond and…”
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VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects by Bazan-Peregrino, Miriam, Garcia-Carbonero, Rocio, Laquente, Berta, Álvarez, Rafael, Mato-Berciano, Ana, Gimenez-Alejandre, Marta, Morgado, Sara, Rodríguez-García, Alba, Maliandi, Maria V, Riesco, M Carmen, Moreno, Rafael, Ginestà, Mireia M, Perez-Carreras, Mercedes, Gornals, Joan B, Prados, Susana, Perea, Sofía, Capella, Gabriel, Alemany, Ramon, Salazar, Ramon, Blasi, Emma, Blasco, Carmen, Cascallo, Manel, Hidalgo, Manuel

“…BackgroundPancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplastic stroma that limits the delivery of anticancer agents. VCN-01 is an…”
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Adenovirus i-Leader Truncation Bioselected Against Cancer-associated Fibroblasts to Overcome Tumor Stromal Barriers by Puig-Saus, Cristina, Gros, Alena, Alemany, Ramon, Cascalló, Manel

“…Tumor-associated stromal cells constitute a major hurdle in the antitumor efficacy with oncolytic adenoviruses. To overcome this biological barrier, an in…”
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Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01 by Vera, Beatriz, Martínez-Vélez, Naiara, Xipell, Enric, Acanda de la Rocha, Arlet, Patiño-García, Ana, Saez-Castresana, Javier, Gonzalez-Huarriz, Marisol, Cascallo, Manel, Alemany, Ramón, Alonso, Marta M

“…Despite the recent advances in the development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal. Therapy with…”
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Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses by Rojas, Juan J, Guedan, Sonia, Searle, Peter F, Martinez-Quintanilla, Jordi, Gil-Hoyos, Raúl, Alcayaga-Miranda, Francisca, Cascallo, Manel, Alemany, Ramon

“…Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at the tumor mass. However, tumor stroma imposes barriers difficult…”
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Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5 by Coughlan, Lynda, Vallath, Sabari, Gros, Alena, Giménez-Alejandre, Marta, Van Rooijen, N, Thomas, Gareth J, Baker, Andrew H, Cascalló, Manel, Alemany, Ramon, Hart, Ian R

“…Achieving high-efficiency tumor targeting after systemic delivery is a considerable challenge facing oncolytic gene therapists. Efficient retargeting should be…”
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Correction: Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01 by Vera, Beatriz, Martínez-Vélez, Naiara, Xipell, Enric, Acanda de la Rocha, Arlet, Patiño-García, Ana, Castresana, Javier S, Gonzalez-Huarriz, Marisol, Cascallo, Manel, Alemany, Ramón, Alonso, Marta M

“…[This corrects the article DOI: 10.1371/journal.pone.0147211.]…”
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Ras-dependent oncolysis with an adenovirus VAI mutant by CASCALLO, Manel, CAPELLA, Gabriel, MAZO, Adela, ALEMANY, Ramon

“…Adenovirus synthesize proteins that interact with oncogene and tumor suppressor gene products to set the cell for virus replication. Mutant viruses defective…”
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Adeno-associated virus enhances wild-type and oncolytic adenovirus spread by Laborda, Eduardo, Puig-Saus, Cristina, Cascalló, Manel, Chillón, Miguel, Alemany, Ramon

“…The contamination of adenovirus (Ad) stocks with adeno-associated viruses (AAV) is usually unnoticed, and it has been associated with lower Ad yields upon…”
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Positive selection of gene-modified cells increases the efficacy of pancreatic cancer suicide gene therapy by Martinez-Quintanilla, Jordi, Cascallo, Manel, Gros, Alena, Fillat, Cristina, Alemany, Ramon

“…Thymidine kinase (TK)-mediated suicide gene therapy has been considered for the treatment of pancreatic cancer. However, despite a bystander effect, the…”
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Anti-migratory and anti-angiogenic effect of p16 : A novel localization at membrane ruffles and lamellipodia in endothelial cells by ALHAJA, Elena, ADAN, Jaume, PIULATS, Jaume, PAGAN, Roser, MITJANS, Francesc, CASCALLO, Manel, RODRIGUEZ, Mercè, NOE, Veronique, CIUDAD, Carlos J, MAZO, Adela, VILARO, Senen

“…Recent evidence has established different functions for the tumor suppressor protein, p16(INK4A) aside from controlling the cell cycle. Here we report that…”
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Enhancement of gemcitabine-induced apoptosis by restoration of p53 function in human pancreatic tumors by Cascalló, Manel, Calbó, Joaquim, Capellà, Gabriel, Fillat, Cristina, Pastor-Anglada, Marçal, Mazo, Adela

“…Human pancreatic adenocarcinomas are highly resistant to conventional treatment modalities, specially to chemotherapy. Among the genes that modulate apoptosis…”
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Adenovirus-mediated wt-p16 reintroduction induces cell cycle arrest or apoptosis in pancreatic cancer by Calbó, J, Marotta, M, Cascalló, M, Roig, J M, Gelpí, J L, Fueyo, J, Mazo, A

“…Pancreatic cancer has long carried poor prognosis. The development of new therapeutic approaches is particularly urgent. Inactivation of the tumor-suppressor…”
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Modulation of drug cytotoxicity by reintroduction of wild-type p53 gene (Ad5CMV-p53) in human pancreatic cancer by Cascalló, M, Calbó, J, Gelpí, J L, Mazo, A

“…Chemotherapy does not significantly improve prognosis in pancreatic cancer. New therapeutical approaches involving p53 gene replacement appear to be very…”
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