Search Results - "Casas, Rosaura"

Intralymphatic Injection of Autoantigen in Type 1 Diabetes by Ludvigsson, Johnny, Wahlberg, Jeanette, Casas, Rosaura

“…Preserved beta-cell function may improve outcomes in patients with type 1 diabetes. In this pilot trial, residual beta-cell function was preserved in six…”
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Serum miRNA levels are related to glucose homeostasis and islet autoantibodies in children with high risk for type 1 diabetes by Åkerman, Linda, Casas, Rosaura, Ludvigsson, Johnny, Tavira, Beatriz, Skoglund, Camilla

“…Micro RNAs (miRNAs) are promising disease biomarkers due to their high stability. Their expression in serum is altered in type 1 diabetes, but whether…”
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Increase of Neutrophil Extracellular Traps, Mitochondrial DNA and Nuclear DNA in Newly Diagnosed Type 1 Diabetes Children but Not in High-Risk Children by Skoglund, Camilla, Appelgren, Daniel, Johansson, Ingela, Casas, Rosaura, Ludvigsson, Johnny

“…Neutrophil extracellular traps (NETs) and mitochondrial DNA (mtDNA) are inflammatory mediators involved in the development of type 1 diabetes (T1D)…”
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Intralymphatic GAD-alum Injection Modulates B Cell Response and Induces Follicular Helper T Cells and PD-1+ CD8+ T Cells in Patients With Recent-Onset Type 1 Diabetes by Barcenilla, Hugo, Pihl, Mikael, Wahlberg, Jeanette, Ludvigsson, Johnny, Casas, Rosaura

“…Antigen-specific immunotherapy is an appealing strategy to preserve beta-cell function in type 1 diabetes, although the approach has yet to meet its…”
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Mass Cytometry Identifies Distinct Subsets of Regulatory T Cells and Natural Killer Cells Associated With High Risk for Type 1 Diabetes by Barcenilla, Hugo, Åkerman, Linda, Pihl, Mikael, Ludvigsson, Johnny, Casas, Rosaura

“…Type 1 diabetes (T1D) is characterized by autoimmune destruction of insulin producing β-cells. The time from onset of islet autoimmunity to manifest clinical…”
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Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients by Casas, Rosaura, Dietrich, Fabrícia, Barcenilla, Hugo, Tavira, Beatriz, Wahlberg, Jeanette, Achenbach, Peter, Ludvigsson, Johnny

“…In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation of residual beta cell function makes the disease milder,…”
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Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases by Magnusson, Louise, Espes, Daniel, Casas, Rosaura, Carlsson, Per-Ola

“…Despite that autoimmune diseases share similar immunogenetic mechanisms, studies comparing the protein composition in peripheral blood from patients with…”
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GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes by Ludvigsson, Johnny, Faresjö, Maria, Hjorth, Maria, Axelsson, Stina, Chéramy, Mikael, Pihl, Mikael, Vaarala, Outi, Forsander, Gun, Ivarsson, Sten, Johansson, Calle, Lindh, Agne, Nilsson, Nils-Östen, Åman, Jan, Örtqvist, Eva, Zerhouni, Peter, Casas, Rosaura

“…This study aimed to test whether injections of alum-formulated glutamic acid decarboxylase 65 (GAD), a major autoantigen in type 1 diabetes mellitus, would…”
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Intralymphatic glutamic acid decarboxylase administration in type 1 diabetes patients induced a distinctive early immune response in patients with DR3DQ2 haplotype by Puente-Marin, Sara, Dietrich, Fabrícia, Achenbach, Peter, Barcenilla, Hugo, Ludvigsson, Johnny, Casas, Rosaura

“…GAD-alum given into lymph nodes to Type 1 diabetes (T1D) patients participating in a multicenter, randomized, placebo-controlled double-blind study seemed to…”
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Intra-lymphatic administration of GAD-alum in type 1 diabetes: long-term follow-up and effect of a late booster dose (the DIAGNODE Extension trial) by Casas, Rosaura, Dietrich, Fabrícia, Puente-Marin, Sara, Barcenilla, Hugo, Tavira, Beatriz, Wahlberg, Jeannette, Achenbach, Peter, Ludvigsson, Johnny

“…Aim To evaluate the long-term effect of intra-lymphatic administration of GAD-alum and a booster dose 2.5 years after the first intervention (DIAGNODE…”
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Mass Cytometry Studies of Patients With Autoimmune Endocrine Diseases Reveal Distinct Disease-Specific Alterations in Immune Cell Subsets by Magnusson, Louise, Barcenilla, Hugo, Pihl, Mikael, Bensing, Sophie, Espes, Daniel, Carlsson, Per-Ola, Casas, Rosaura

“…Although there is evidence that autoimmune diseases share similar immunogenetic mechanisms, studies comparing peripheral CD45 cells from patients with…”
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Phase III, randomised, double-blind, placebo-controlled, multicentre trial to evaluate the efficacy and safety of rhGAD65 to preserve endogenous beta cell function in adolescents and adults with recently diagnosed type 1 diabetes, carrying the genetic HLA DR3-DQ2 haplotype: the DIAGNODE-3 study protocol by Ludvigsson, Johnny, Eriksson, Linnea, Nowak, Christoph, Teixeira, Pedro F, Widman, Martina, Lindqvist, Anton, Casas, Rosaura, Lind, Marcus, Hannelius, Ulf

“…IntroductionType 1 diabetes (T1D) is an autoimmune disease leading to the destruction of the insulin-producing beta cells resulting in insulin deficiency and…”
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Long-lasting immune responses 4 years after GAD-alum treatment in children with type 1 diabetes by Axelsson, Stina, Chéramy, Mikael, Hjorth, Maria, Pihl, Mikael, Akerman, Linda, Martinuzzi, Emanuela, Mallone, Roberto, Ludvigsson, Johnny, Casas, Rosaura

“…A phase II clinical trial with glutamic acid decarboxylase (GAD) 65 formulated with aluminium hydroxide (GAD-alum) has shown efficacy in preserving residual…”
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Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes by Ludvigsson, Johnny, Achenbach, Peter, Wahlberg, Jeanette, Barcenilla, Hugo, Tavira, Beatriz, Casas, Rosaura

“…GAD-alum given into lymph nodes to type 1 diabetes patients participating in an open-label pilot trial resulted in preservation of C-peptide similar to…”
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Pregnancy induces pancreatic insulin secretion in women with long-standing type 1 diabetes by Espes, Daniel, Magnusson, Louise, Caballero-Corbalan, José, Schwarcz, Erik, Casas, Rosaura, Carlsson, Per-Ola

“…IntroductionPregnancy entails both pancreatic adaptations with increasing β-cell mass and immunological alterations in healthy women. In this study, we have…”
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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus by Paulsson, Johan F, Ludvigsson, Johnny, Carlsson, Annelie, Casas, Rosaura, Forsander, Gun, Ivarsson, Sten A, Kockum, Ingrid, Lernmark, Åke, Marcus, Claude, Lindblad, Bengt, Westermark, Gunilla T

“…Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose…”
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Lessons From the Mixed-Meal Tolerance Test by Besser, Rachel E.J., Shields, Beverley M., Casas, Rosaura, Hattersley, Andrew T., Ludvigsson, Johnny

“…OBJECTIVE Mixed-meal tolerance test (MMTT) area under the curve C-peptide (AUC CP) is the gold-standard measure of endogenous insulin secretion in type 1…”
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Combined vitamin D, ibuprofen and glutamic acid decarboxylase-alum treatment in recent onset Type I diabetes: lessons from the DIABGAD randomized pilot trial by Ludvigsson, Johnny, Routray, Indusmita, Elluru, Sriramulu, Leanderson, Per, Larsson, Helena E, Rathsman, Björn, Hanås, Ragnar, Carlsson, Annelie, Ek, Torben, Samuelsson, Ulf, Torbjörnsdotter, Torun, Åman, Jan, Örtqvist, Eva, Badwal, Karun, Beam, Craig, Casas, Rosaura

“…Double-blind placebo-controlled intervention using glutamic acid decarboxylase (GAD)-alum, vitamin D and Ibuprofen in recent onset Type I diabetes (T1D)…”
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Letter: Intralymphatic Injection of Autoantigen in Type 1 Diabetes in NEW ENGLAND JOURNAL OF MEDICINE, vol 376, issue 7, pp 697-699 by Ludvigsson, Johnny, Wahlberg Topp, Jeanette, Casas, Rosaura

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Immune response differs between intralymphatic or subcutaneous administration of GAD‐alum in individuals with recent onset type 1 diabetes by Dietrich, Fabrícia, Barcenilla, Hugo, Tavira, Beatriz, Wahlberg, Jeanette, Achenbach, Peter, Ludvigsson, Johnny, Casas, Rosaura

“…Aims Immunomodulation with autoantigens potentially constitutes a specific and safe treatment for type 1 diabetes (T1D). Studies with GAD‐alum administrated…”
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