Search Results - "Casarotto, C"
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Psychedelics promote plasticity by directly binding to BDNF receptor TrkB
Published in Nature neuroscience (01-06-2023)“…Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants. We…”
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Opposing Roles for Cannabinoid Receptor Type-1 (CB ) and Transient Receptor Potential Vanilloid Type-1 Channel (TRPV1) on the Modulation of Panic-Like Responses in Rats
Published in Neuropsychopharmacology (New York, N.Y.) (01-01-2012)“…The midbrain dorsal periaqueductal gray (dPAG) has an important role in orchestrating anxiety- and panic-related responses. Given the cellular and behavioral…”
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Nitric Oxide Synthase inhibition counteracts the stress‐induced DNA methyltransferase 3b expression in the hippocampus of rats
Published in The European journal of neuroscience (01-05-2022)“…It has been postulated that the activation of NMDA receptors (NMDAr) and nitric oxide (NO) production in the hippocampus is involved in the behavioral…”
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Vanishing permanent glaciers: climate change is threatening a European Union habitat (Code 8340) and its poorly known biodiversity
Published in Biodiversity and conservation (01-06-2021)“…The cryosphere (i.e. glaciers and permafrost) and its related landforms offer a wide range of ecosystem services, thus they have strong relationships with…”
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USE OF HISTORICAL AERIAL IMAGES FOR 3D MODELLING OF GLACIERS IN THE PROVINCE OF TRENTO
Published in International archives of the photogrammetry, remote sensing and spatial information sciences. (14-08-2020)“…Historical aerial images represent a source of information of great value for glacier monitoring, as they cover the area of interest at a well-defined epoch…”
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Monoamine involvement in the antidepressant-like effect induced by P2 blockade
Published in Brain research (01-12-2017)“…•Combined sub-effective doses of PPADS and fluoxetine yield antidepressant-like effect.•Combined sub-effective doses of PPADS and reboxetine yield…”
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NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress
Published in Behavioural brain research (01-07-2016)“…•Hippocampal synaptic transmission inactivation does not affect swimming behavior.•Blocking NMDA-NO system into dorsal hippocampus promote antidepressant-like…”
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Decay of a long-term monitored glacier: Careser Glacier (Ortles-Cevedale, European Alps)
Published in The cryosphere (03-12-2013)“…The continuation of valuable, long-term glacier observation series is threatened by the accelerated mass loss which currently affects a large portion of…”
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Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21
Published in Pharmaceuticals (Basel, Switzerland) (06-08-2021)“…Blockers of angiotensin II type 1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type 2…”
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Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors
Published in Behavioural pharmacology (01-07-2010)“…Cannabidiol (CBD) is a major nonpsychotomimetic component of Cannabis sativa that has been shown to have an anxiolytic effect in human and animal models…”
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Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors
Published in PeerJ (San Francisco, CA) (21-02-2019)“…Administration of anandamide (AEA) or 2-arachidonoylglycerol (2AG) induces CB1 coupling and activation of TRKB receptors, regulating the neuronal migration and…”
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Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness model
Published in PeerJ (San Francisco, CA) (21-10-2019)“…Purinergic receptors, especially P2RX, are associated to the severity of symptoms in patients suffering from depressive and bipolar disorders, and genetic…”
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Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania
Published in PeerJ (San Francisco, CA) (17-04-2018)“…Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals…”
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Anti-aversive effects of the atypical antipsychotic, aripiprazole, in animal models of anxiety
Published in Journal of psychopharmacology (Oxford) (01-06-2011)“…Aripiprazole is a unique antipsychotic that seems to act as a partial agonist at dopamine D2-receptors, contrasting with other drugs in this class, which are…”
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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Published in Cell (04-03-2021)“…It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane…”
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The antimanic-like effect of phenytoin and carbamazepine on methylphenidate-induced hyperlocomotion: role of voltage-gated sodium channels
Published in Fundamental & clinical pharmacology (01-12-2013)“…The objective of this study was to verify whether phenytoin modifies methylphenidate‐induced hyperlocomotion, an animal model for screening antimanic‐like…”
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Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin
Published in Behavioural pharmacology (01-02-2012)“…Changes in brain-derived neurotrophic factor (BDNF)-mediated signaling in the hippocampus have been implicated in the etiology of depression and in the mode of…”
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Beyond good and evil: A putative continuum-sorting hypothesis for the functional role of proBDNF/BDNF-propeptide/mBDNF in antidepressant treatment
Published in Neuroscience and biobehavioral reviews (01-07-2018)“…•Stress and antidepressants modulate brain neuroplasticity and BDNF levels.•BDNF production is tied to previous proBDNF making.•Binary sorting hypothesis…”
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Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2
Published in The Journal of biological chemistry (29-11-2019)“…Several antidepressant drugs activate tropomyosin-related kinase B (TRKB) receptor, but it remains unclear whether these compounds employ a common mechanism…”
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Cholesterol‐recognition motifs in the transmembrane domain of the tyrosine kinase receptor family: The case of TRKB
Published in The European journal of neuroscience (01-05-2021)“…Cholesterol is an essential constituent of cell membranes. The discovery of cholesterol‐recognition amino acid consensus (CRAC) motif in proteins indicated a…”
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