Search Results - "Casarini, Simona"

Minimal residual disease negativity by next-generation flow cytometry is associated with improved organ response in AL amyloidosis by Palladini, Giovanni, Paiva, Bruno, Wechalekar, Ashutosh, Massa, Margherita, Milani, Paolo, Lasa, Marta, Ravichandran, Sriram, Krsnik, Isabel, Basset, Marco, Burgos, Leire, Nuvolone, Mario, Lecumberri, Ramón, Foli, Andrea, Puig, Noemi, Sesta, Melania Antonietta, Bozzola, Margherita, Cascino, Pasquale, Nevone, Alice, Ripepi, Jessica, Berti, Pierpaolo, Casarini, Simona, Annibali, Ombretta, Orfao, Alberto, San-Miguel, Jesus, Merlini, Giampaolo

“…Light chain (AL) amyloidosis is caused by a small B-cell clone producing light chains that form amyloid deposits and cause organ dysfunction. Chemotherapy aims…”
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A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli by Rognoni, Paola, Lavatelli, Francesca, Casarini, Simona, Palladini, Giovanni, Verga, Laura, Pedrazzoli, Paolo, Valentini, Giovanna, Merlini, Giampaolo, Perfetti, Vittorio

“…Monoclonal immunoglobulin light chains are normally synthesized in excess compared to the heavy chain partners and can be detected in serum and urine ("free"…”
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The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity by Oliva, Laura, Orfanelli, Ugo, Resnati, Massimo, Raimondi, Andrea, Orsi, Andrea, Milan, Enrico, Palladini, Giovanni, Milani, Paolo, Cerruti, Fulvia, Cascio, Paolo, Casarini, Simona, Rognoni, Paola, Touvier, Thierry, Marcatti, Magda, Ciceri, Fabio, Mangiacavalli, Silvia, Corso, Alessandro, Merlini, Giampaolo, Cenci, Simone

“…Systemic light chain (AL) amyloidosis is caused by the clonal production of an unstable immunoglobulin light chain (LC), which affects organ function…”
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The repertoire of λ light chains causing predominant amyloid heart involvement and identification of a preferentially involved germline gene, IGLV1-44 by Perfetti, Vittorio, Palladini, Giovanni, Casarini, Simona, Navazza, Valentina, Rognoni, Paola, Obici, Laura, Invernizzi, Rosangela, Perlini, Stefano, Klersy, Catherine, Merlini, Giampaolo

“…Monoclonal Ig light chains (LC) can be responsible for pathologic conditions in humans, as in systemic amyloid light amyloidosis. Protean clinical…”
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An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis by Nevone, Alice, Girelli, Maria, Mangiacavalli, Silvia, Paiva, Bruno, Milani, Paolo, Cascino, Pasquale, Piscitelli, Maggie, Speranzini, Valentina, Cartia, Claudio Salvatore, Benvenuti, Pietro, Goicoechea, Ibai, Fazio, Francesca, Basset, Marco, Foli, Andrea, Nanci, Martina, Mazzini, Giulia, Caminito, Serena, Sesta, Melania Antonietta, Casarini, Simona, Rognoni, Paola, Lavatelli, Francesca, Petrucci, Maria Teresa, Olimpieri, Pier Paolo, Ricagno, Stefano, Arcaini, Luca, Merlini, Giampaolo, Palladini, Giovanni, Nuvolone, Mario

“…Immunoglobulin light chain (AL) amyloidosis is caused by a small, minimally proliferating B-cell/plasma-cell clone secreting a patient-unique,…”
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632 PREVALENCE OF VARIANT GENOTYPE IN PATIENTS WITH SUSPECTED CARDIAC ATTR AMYLOIDOSIS by Mussinelli, Roberta, Milani, Paolo, Casarini, Simona, Nuvolone, Mario, Fabris, Francesca, Perlini, Stefano, Merlini, Giampaolo, Palladini, Giovanni, Obici, Laura

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Identification of Amyloidogenic Light Chains Requires the Combination of Serum-Free Light Chain Assay with Immunofixation of Serum and Urine by Palladini, Giovanni, Russo, Paola, Bosoni, Tiziana, Verga, Laura, Sarais, Gabriele, Lavatelli, Francesca, Nuvolone, Mario, Obici, Laura, Casarini, Simona, Donadei, Simona, Albertini, Riccardo, Righetti, Gabriella, Marini, Maddalena, Graziani, Maria Stella, Melzi D'Eril, Gian Vico, Moratti, Remigio, Merlini, Giampaolo

“…The diagnosis of systemic immunoglobulin light-chain (AL) amyloidosis requires demonstration of amyloid deposits in a tissue biopsy and amyloidogenic…”
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Single‐molecule real‐time sequencing of the M protein: Toward personalized medicine in monoclonal gammopathies by Cascino, Pasquale, Nevone, Alice, Piscitelli, Maggie, Scopelliti, Claudia, Girelli, Maria, Mazzini, Giulia, Caminito, Serena, Russo, Giancarlo, Milani, Paolo, Basset, Marco, Foli, Andrea, Fazio, Francesca, Casarini, Simona, Massa, Margherita, Bozzola, Margherita, Ripepi, Jessica, Sesta, Melania Antonietta, Acquafredda, Gloria, De Cicco, Marica, Moretta, Antonia, Rognoni, Paola, Milan, Enrico, Ricagno, Stefano, Lavatelli, Francesca, Petrucci, Maria Teresa, Miho, Enkelejda, Klersy, Catherine, Merlini, Giampaolo, Palladini, Giovanni, Nuvolone, Mario

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Single Molecule Real-Time Sequencing of the M Protein (SMaRT M-Seq): Toward Personalized Medicine Approaches in Monoclonal Gammopathies by Cascino, Pasquale, Nevone, Alice, Scopelliti, Claudia, Girelli, Maria, Mazzini, Giulia, Caminito, Serena, Russo, Giancarlo, Milani, Paolo, Basset, Marco, Foli, Andrea, Fazio, Francesca, Casarini, Simona, Massa, Margherita, Bozzola, Margherita, Ripepi, Jessica, Sesta, Melania Antonietta, Acquafredda, Gloria, De Cicco, Marica, Moretta, Antonia, Rognoni, Paola, Milan, Enrico, Ricagno, Stefano, Lavatelli, Francesca, Petrucci, Maria Teresa, Klersy, Catherine, Merlini, Giampaolo, Palladini, Giovanni, Nuvolone, Mario

“…Introduction In patients affected by monoclonal gammopathies, tumoral B cells or plasma cells secrete a monoclonal antibody (termed M protein), which can be…”
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Prognostication of survival and progression to dialysis in AA amyloidosis by Palladini, Giovanni, Riva, Eloisa, Basset, Marco, Russo, Francesca, Milani, Paolo, Pasquinucci, Ettore, Foli, Andrea, Lavatelli, Francesca, Nuvolone, Mario, Casarini, Simona, Obici, Laura, Merlini, Giampaolo

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Diflunisal in late-onset FAP patients with moderate to severe neuropathy by Obici, Laura, Cortese, Andrea, Perlini, Stefano, Lozza, Alessandro, Casarini, Simona, Alfonsi, Enrico, Merlini, Giampaolo

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A novel approach for the purification and proteomic analysis of pathogenic immunoglobulin free light chains from serum by Lavatelli, Francesca, Brambilla, Francesca, Valentini, Veronica, Rognoni, Paola, Casarini, Simona, Di Silvestre, Dario, Perfetti, Vittorio, Palladini, Giovanni, Sarais, Gabriele, Mauri, Pierluigi, Merlini, Giampaolo

“…An excess of circulating monoclonal free immunoglobulin light chains (FLC) is common in plasma cell disorders. A subset of FLC, as amyloidogenic ones, possess…”
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Analysis of Vλ-Jλ expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r(λIII) as a new amyloid-associated germline gene segment by Perfetti, Vittorio, Casarini, Simona, Palladini, Giovanni, Vignarelli, Maurizio Colli, Klersy, Catherine, Diegoli, Marta, Ascari, Edoardo, Merlini, Giampaolo

“…Primary (AL) amyloidosis is a plasma cell dyscrasia characterized by extracellular deposition of monoclonal light-chain variable region (V) fragments in the…”
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Midregional proadrenomedullin (MR-proADM) is a powerful predictor of early death in AL amyloidosis by Palladini, Giovanni, Barassi, Alessandra, Perlini, Stefano, Milani, Paolo, Foli, Andrea, Russo, Paola, Albertini, Riccardo, Obici, Laura, Lavatelli, Francesca, Sarais, Gabriele, Casarini, Simona, Moratti, Remigio, Melzi d'Eril, Gian Vico, Merlini, Giampaolo

“…Background: Cardiac biomarkers play a major role in the identification of patients at risk of early death in AL amyloidosis, and a staging system based on…”
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Use of the Novel Monoclonal Assay for the Measurement of Circulating Free Light Chain in the Diagnosis, Prognostication of Survival and Assessment of Response to Therapy in AL Amyloidosis by Palladini, Giovanni, Bosoni, Tiziana, Milani, Paolo, Pirolini, Laura, Foli, Andrea, Bergolis, Filomena Li, Lavatelli, Francesca, Roggeri, Leda, Cigalini, Elena, Repetti, Ilaria, Valentini, Veronica, Casarini, Simona, Albertini, Riccardo, Merlini, Giampaolo

“…Abstract 3913 The possibility of measuring the circulating free light chains (FLC) improved our ability to detect the amyloidogenic clone, allowed refined risk…”
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Downmodulation of CXCL8/IL-8 receptors on neutrophils after recruitment in the airways by Pignatti, Patrizia, Moscato, Gianna, Casarini, Simona, Delmastro, Monica, Poppa, Mariangela, Brunetti, Giuseppe, Pisati, Paolo, Balbi, Bruno

“…CXCL8/IL-8 is the most significant chemokine for neutrophils, and CXC chemokine receptor (CXCR) 1 and 2 are its 2 receptors, which are downmodulated by…”
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A Strategy for Synthesis of Pathogenic Human Immunoglobulin Free Light Chains in E. coli: e76022 by Rognoni, Paola, Lavatelli, Francesca, Casarini, Simona, Palladini, Giovanni, Verga, Laura, Pedrazzoli, Paolo, Valentini, Giovanna, Merlini, Giampaolo, Perfetti, Vittorio

“…Monoclonal immunoglobulin light chains are normally synthesized in excess compared to the heavy chain partners and can be detected in serum and urine ("free"…”
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Translocation t(4;14)(p16.3;q32) Is a Recurrent Genetic Lesion in Primary Amyloidosis by Perfetti, Vittorio, Coluccia, Addolorata M.L., Intini, Daniela, Malgeri, Ursula, Vignarelli, Maurizio Colli, Casarini, Simona, Merlini, Giampaolo, Neri, Antonino

“…Primary amyloidosis is a fatal disorder characterized by low numbers of clonal plasma cells in the bone marrow and the systemic deposition of light chain…”
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Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment by Perfetti, Vittorio, Casarini, Simona, Palladini, Giovanni, Vignarelli, Maurizio Colli, Klersy, Catherine, Diegoli, Marta, Ascari, Edoardo, Merlini, Giampaolo

“…Primary (AL) amyloidosis is a plasma cell dyscrasia characterized by extracellular deposition of monoclonal light-chain variable region (V) fragments in the…”
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Protein aggregation by Merlini, G, Bellotti, V, Andreola, A, Palladini, G, Obici, L, Casarini, S, Perfetti, V

“…Protein aggregation occurs in vivo as a result of improper folding or misfolding. Diverse diseases arise from protein misfolding and are now grouped under the…”
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