Search Results - "Casar Tena, Teresa"

Resting cells rely on the DNA helicase component MCM2 to build cilia by Casar Tena, Teresa, Maerz, Lars D, Szafranski, Karol, Groth, Marco, Blätte, Tamara J, Donow, Cornelia, Matysik, Sabrina, Walther, Paul, Jeggo, Penelope A, Burkhalter, Martin D, Philipp, Melanie

“…Abstract Minichromosome maintenance (MCM) proteins facilitate replication by licensing origins and unwinding the DNA double strand. Interestingly, the number…”
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Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors by Maerz, Lars D, Casar Tena, Teresa, Gerhards, Julian, Donow, Cornelia, Jeggo, Penelope A, Philipp, Melanie

“…Meier-Gorlin syndrome (MGS) is a rare, congenital primordial microcephalic dwarfism disorder. MGS is caused by genetic variants of components of the origin…”
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Left-right asymmetry in the light of TOR: An update on what we know so far by Casar Tena, Teresa, Burkhalter, Martin D., Philipp, Melanie

“…The internal left‐right (LR) asymmetry is a characteristic that exists throughout the animal kingdom from roundworms over flies and fish to mammals. Cilia,…”
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ATR promotes cilia signalling: links to developmental impacts by Stiff, Tom, Casar Tena, Teresa, O'Driscoll, Mark, Jeggo, Penny A, Philipp, Melanie

“…Mutations in ATR(ataxia telangiectasia and RAD3-related) cause Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder. Hitherto, the clinical…”
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Centrobin controls primary ciliogenesis in vertebrates by Ogungbenro, Yetunde Adesanya, Tena, Teresa Casar, Gaboriau, David, Lalor, Pierce, Dockery, Peter, Philipp, Melanie, Morrison, Ciaran G

“…The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing…”
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Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage by Burkhalter, Martin D., Stiff, Tom, Maerz, Lars D., Casar Tena, Teresa, Wiese, Heike, Gerhards, Julian, Sailer, Steffen A., Vu, Linh Anna Trúc, Duong Phu, Max, Donow, Cornelia, Alupei, Marius, Iben, Sebastian, Groth, Marco, Wiese, Sebastian, Church, Joseph A., Jeggo, Penelope A., Philipp, Melanie

“…The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired brain and skull growth. Often,…”
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Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies by Hempel, Maja, Casar Tena, Teresa, Diehl, Thilo, Burczyk, Martina S., Strom, Tim M., Kubisch, Christian, Philipp, Melanie, Lessel, Davor

“…GATA5 belongs to the GATA family of transcription factors characterized by highly evolutionarily conserved zinc-finger DNA-binding domains. Mouse models have…”
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The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5 by Lessel, Davor, Muhammad, Tariq, Casar Tena, Teresa, Moepps, Barbara, Burkhalter, Martin D., Hitz, Marc-Phillip, Toka, Okan, Rentzsch, Axel, Schubert, Stephan, Schalinski, Adelheid, Bauer, Ulrike M. M., Kubisch, Christian, Ware, Stephanie M., Philipp, Melanie

“…G protein-coupled receptor kinase 5 (GRK5) is a regulator of cardiac performance and a potential therapeutic target in heart failure in the adult…”
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Assessing Smoothened-mediated Hedgehog signaling in zebrafish by Tena, Teresa Casar, Philipp, Melanie

“…Smoothened belongs to the class of atypical G protein-coupled receptors and serves as the transducing molecule in Hedgehog (Hh) signaling. Hh proteins comprise…”
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Chapter 8 - Assessing Smoothened-mediated Hedgehog signaling in zebrafish by Tena, Teresa Casar, Philipp, Melanie

“…Smoothened belongs to the class of atypical G protein-coupled receptors and serves as the transducing molecule in Hedgehog (Hh) signaling. Hh proteins comprise…”
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Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish by Burczyk, Martina S, Burkhalter, Martin D, Tena, Teresa Casar, Grisanti, Laurel A, Kauk, Michael, Matysik, Sabrina, Donow, Cornelia, Kustermann, Monika, Rothe, Melanie, Cui, Yinghong, Raad, Farah, Laue, Svenja, Moretti, Allessandra, Zimmermann, Wolfram-H, Wess, Jürgen, Kühl, Michael, Hoffmann, Carsten, Tilley, Douglas G, Philipp, Melanie

“…Deterioration or inborn malformations of the cardiac conduction system (CCS) interfere with proper impulse propagation in the heart and may lead to sudden…”
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