Search Results - "Casanovas i Casanovas, Oriol"

Unraveling the Role of Angiogenesis in Cancer Ecosystems by Zuazo-Gaztelu, Iratxe, Casanovas, Oriol

“…Activation of the tumor and stromal cell-driven angiogenic program is one of the first requirements in the tumor ecosystem for growth and dissemination. The…”
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ALK1 Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K Activation by Alsina-Sanchís, Elisenda, García-Ibáñez, Yaiza, Figueiredo, Ana M, Riera-Domingo, Carla, Figueras, Agnès, Matias-Guiu, Xavier, Casanovas, Oriol, Botella, Luisa M, Pujana, Miquel A, Riera-Mestre, Antoni, Graupera, Mariona, Viñals, Francesc

“…OBJECTIVE—ALK1 (activin-receptor like kinase 1) is an endothelial cell-restricted receptor with high affinity for BMP (bone morphogenetic protein) 9 TGF-β…”
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The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels by Alsina‐Sanchis, Elisenda, Figueras, Agnès, Lahiguera, Álvaro, Vidal, August, Casanovas, Oriol, Graupera, Mariona, Villanueva, Alberto, Viñals, Francesc

“…In a search for new therapeutic targets for treating epithelial ovarian cancer, we analyzed the Transforming Growth Factor Beta (TGFβ) signaling pathway in…”
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Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility by Angulo-Urarte, Ana, Casado, Pedro, Castillo, Sandra D., Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana M., Castel, Pau, Rajeeve, Vinothini, Milà-Guasch, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laia, Casanovas, Oriol, Viñals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R., Graupera, Mariona

“…Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are…”
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Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients by Jiménez-Valerio, Gabriela, Martínez-Lozano, Mar, Bassani, Nicklas, Vidal, August, Ochoa-de-Olza, María, Suárez, Cristina, García-del-Muro, Xavier, Carles, Joan, Viñals, Francesc, Graupera, Mariona, Indraccolo, Stefano, Casanovas, Oriol

“…Antiangiogenic drugs are used clinically for treatment of renal cell carcinoma (RCC) as a standard first-line treatment. Nevertheless, these agents primarily…”
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PTEN mediates Notch-dependent stalk cell arrest in angiogenesis by Serra, Helena, Chivite, Iñigo, Angulo-Urarte, Ana, Soler, Adriana, Sutherland, James D., Arruabarrena-Aristorena, Amaia, Ragab, Anan, Lim, Radiance, Malumbres, Marcos, Fruttiger, Marcus, Potente, Michael, Serrano, Manuel, Fabra, Àngels, Viñals, Francesc, Casanovas, Oriol, Pandolfi, Pier Paolo, Bigas, Anna, Carracedo, Arkaitz, Gerhardt, Holger, Graupera, Mariona

“…Coordinated activity of VEGF and Notch signals guides the endothelial cell (EC) specification into tip and stalk cells during angiogenesis. Notch activation in…”
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Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors by Soler, Adriana, Figueiredo, Ana M, Castel, Pau, Martin, Laura, Monelli, Erika, Angulo-Urarte, Ana, Milà-Guasch, Maria, Viñals, Francesc, Baselga, Jose, Casanovas, Oriol, Graupera, Mariona

“…Mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an exciting…”
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis by Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo, Ana, Guillermet-Guibert, Julie, Friedman, Lori S, Viñals, Francesc, Gerhardt, Holger, Casanovas, Oriol, Graupera, Mariona, Vanhaesebroeck, Bart

“…Understanding the direct, tumor cell-intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer…”
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The PDGFRβ-AKT Pathway Contributes to CDDP-Acquired Resistance in Testicular Germ Cell Tumors by JULIACHS, M, MUNOZ, C, VINALS, F, MOUTINHO, C. A, VIDAL, A, CONDOM, E, ESTELLER, M, GRAUPERA, M, CASANOVAS, O, GERMA, J. R, VILLANUEVA, A

“…We examined whether PI3K-AKT or extracellular signal-regulated kinase (ERK) signaling pathways could play a role in the development of cisplatin (CDDP)…”
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Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility by Angulo Urarte, Ana, Casado, Pedro, Castillo, Sandra D, Kobialka, Piotr, Kotini, Maria Paraskevi, Figueiredo, Ana Raquel Martins, Castel Morales, Pau, Rajeeve, Vinothini, Milà-Guasc, Maria, Millan, Jaime, Wiesner, Cora, Serra, Helena, Muixi, Laura, Casanovas i Casanovas, Oriol, Viñals Canals, Francesc, Affolter, Markus, Gerhardt, Holger, Huveneers, Stephan, Belting, Heinz-Georg, Cutillas, Pedro R, Graupera i Garcia-Milà, Mariona

“…Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are…”
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ALK1 loss results in vascular hyperplasia in mice and humans through PI3K activation by Alsina Sanchís, Elisenda, García-Ibáñez, Yaiza, Figueiredo, Ana Raquel Martins, Riera-Domingo, Carla, Figueras i Amat, Agnès, Matias-Guiu, Xavier, Casanovas i Casanovas, Oriol, Botella, Luisa M, Pujana Genestar, M. Ángel, Riera Mestre, Antoni, Graupera i Garcia-Milà, Mariona, Viñals Canals, Francesc

“…Objective: ALK1 (activin-receptor like kinase 1) is an endothelial cell-restricted receptor with high affinity for BMP (bone morphogenetic protein) 9…”
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ALK1 loss results in vascular hyperplasia in mice and humans through PI3K activation by Alsina Sanchís, Elisenda, García-Ibáñez, Yaiza, Figueiredo, Ana Raquel Martins, Riera-Domingo, Carla, Figueras i Amat, Agnès, Matias-Guiu, Xavier, Casanovas i Casanovas, Oriol, Botella, Luisa M, Pujana Genestar, M. Ángel, Riera Mestre, Antoni, Graupera i Garcia-Milà, Mariona, Viñals Canals, Francesc

“…Objective: ALK1 (activin-receptor like kinase 1) is an endothelial cell-restricted receptor with high affinity for BMP (bone morphogenetic protein) 9…”
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Therapeutic benefit of selective inhibition of p110α PI3-kinase in pancreatic neuroendocrine tumors by Soler, Adriana, Figueiredo, Ana M, Castel Morales, Pau, Martín Fernández, Laura, Monelli, Erika, Angulo Urarte, Ana, Milà-Guasch, Maria, Viñals Canals, Francesc, Baselga, Jose, Casanovas i Casanovas, Oriol, Graupera i Garcia-Milà, Mariona

“…Purpose: mutations in the PI3K pathway occur in 16% of patients with pancreatic neuroendocrine tumors (PanNETs), which suggests that these tumors are an…”
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Meetronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells by Vives, Marta, Ginestà, Mireia M, Gracova, Kristina, Graupera i Garcia-Milà, Mariona, Casanovas i Casanovas, Oriol, Capellá, G. (Gabriel), Serrano Piñol, M. Teresa, Laquente, Berta, Viñals Canals, Francesc

“…In this article, the effectiveness of a multi-targeted chemo-switch (C-S) schedule that combines metronomic chemotherapy (MET) after treatment with the maximum…”
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Sunitinib Inhibits Tumor Growth and Synergizes with Cisplatin in Orthotopic Models of Cisplatin-Sensitive and Cisplatin-Resistant Human Testicular Germ Cell Tumors by CASTILLO-AVILA, Wilmar, PIULATS, Josep Maria, VINALS, Francesc, GARCIA DEL MURO, Xavier, VIDAL, August, CONDOM, Enric, CASANOVAS, Oriol, MORA, Josefina, RAMON GERMA, Josep, CAPELLA, Gabriel, VILLANUEVA, Alberto

“…Purpose: Germ cell tumors (GCT) of the testis are highly curable, but those patients who are refractory to cisplatin (CDDP)-based combination chemotherapy have…”
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The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors by Juliachs Milà, Mercè, Muñoz, C, Moutinho, Cátia, Vidal-Bel, August, Condom i Mundó, Enric, Esteller, Manel, Graupera i Garcia-Milà, Mariona, Casanovas i Casanovas, Oriol, Germà Lluch, José Ramón, Villanueva Garatachea, Alberto, Viñals Canals, Francesc

“…Purpose: we examined whether PI3K-AKT or extracellular signal-regulated kinase (ERK) signaling pathways could play a role in the development of cisplatin…”
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The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors by Juliachs Milà, Mercè, Muñoz, C, Moutinho, Cátia, Vidal-Bel, August, Condom i Mundó, Enric, Esteller, Manel, Graupera i Garcia-Milà, Mariona, Casanovas i Casanovas, Oriol, Germà Lluch, José Ramón, Villanueva Garatachea, Alberto, Viñals Canals, Francesc

“…Purpose: we examined whether PI3K-AKT or extracellular signal-regulated kinase (ERK) signaling pathways could play a role in the development of cisplatin…”
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Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors by Juliachs, Mercè, Vidal, August, Del Muro, Xavier Garcia, Piulats, Josep M, Condom, Enric, Casanovas, Oriol, Graupera, Mariona, Germà, Jose R, Villanueva, Alberto, Viñals, Francesc

“…Cisplatin (CDDP) resistance in testicular germ cell tumors (GCTs) is still a clinical challenge, and one associated with poor prognosis. The purpose of this…”
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Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis by Soler, Adriana, Serra, Helena, Pearce, Wayne, Angulo Aguado, Ana, Guillermet-Guibert, Julie, Friedman, Lori S, Viñals Canals, Francesc, Gerhardt, Holger, Casanovas i Casanovas, Oriol, Graupera i Garcia-Milà, Mariona, Vanhaesebroeck, Bart

“…Understanding the direct, tumor cell–intrinsic effects of PI 3-kinase (PI3K) has been a key focus of research to date. Here, we report that cancer…”
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Antiangiogenic effect of gemcitabine following metronomic administration in a pancreas cancer model by Laquente, Berta, Lacasa Salavert, Cristina, Ginestà, Mireia M, Casanovas i Casanovas, Oriol, Figueras i Amat, Agnès, Galán, Maica, García Ribas, Ignacio, Germà Lluch, José Ramón, Capellá, G. (Gabriel), Viñals Canals, Francesc

“…Gemcitabine shows a marked antitumor effect as a result of its cytotoxic action toward proliferative cells. In this article, we aim to investigate the…”
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