Search Results - "Casanova Sepúlveda, Gabriela"
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Regulation and signaling of the LIM domain kinases
Published in BioEssays (03-10-2024)“…The LIM domain kinases (LIMKs) are important actin cytoskeleton regulators. These proteins, LIMK1 and LIMK2, are nodes downstream of Rho GTPases and are the…”
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Journal Article -
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Autoregulation of the LIM kinases by their PDZ domain
Published in Nature communications (19-12-2023)“…LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor…”
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Journal Article -
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Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tail
Published in Nature communications (16-02-2024)“…Cofilin family proteins have essential roles in remodeling the cytoskeleton through filamentous actin depolymerization and severing. The short, unstructured…”
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Journal Article -
4
Molecular biophysical characterization of the third FF domain of Homo sapiens Prp40 homolog A
Published in Journal of molecular structure (05-09-2018)“…Homo sapiens Prp40 Homolog A (HsPrp40A) is a nuclear protein that is involved in pre-mRNA splicing. This modular protein has two WW domains followed by six…”
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Journal Article -
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Autoregulation Mechanism of LIM Domain Kinases
Published 01-01-2023“…LIM kinases 1 (LIMK1) and 2 (LIMK2) are major regulators of cytoskeletal dynamics in the cell. LIMK regulates actin dynamics by phosphorylating the…”
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Dissertation