Aqueous extract of pummelo pulp (Citrus maxima) improves the biochemical profile and reduces the inflammation process in Wistar rats with non-alcoholic fatty liver disease

This study investigated the effect of pummelo extract (Citrus maxima) on biochemical, inflammatory, antioxidant and histological changes in NAFLD rats. Forty male Wistar rats divided into four groups were used: (1) control group; (2) fructose associated with high-fat diet - DHF; (3) normal diet + pu...

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Published in:	Food and chemical toxicology Vol. 178; p. 113933
Main Authors:	Tejada Nunes, Vinícius, Gonçalves, Itamar Luís, Martinez Oliveira, Patricia, Lima Feksa, Denise, Muller de Moura Sarmento, Sílvia, Erminda Schreiner, Gênifer, Klock, Clóvis, Casanova Petry, Charline, da Costa Escobar Piccoli, Jacqueline, Manfredini, Vanusa, Casagrande Denardin, Cristiane
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2023
Subjects:	Animals Biochemical parameters Citrus Diet, High-Fat - adverse effects Inflammation - metabolism Inflammatory markers Liver Male Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - metabolism Oxidative Stress Plant Extracts - pharmacology Plant Extracts - therapeutic use Pummelo Rats Rats, Sprague-Dawley Rats, Wistar Oxidative stress Inflammatory markers Biochemical parameters Non-alcoholic fatty liver disease Pummelo
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Summary:	This study investigated the effect of pummelo extract (Citrus maxima) on biochemical, inflammatory, antioxidant and histological changes in NAFLD rats. Forty male Wistar rats divided into four groups were used: (1) control group; (2) fructose associated with high-fat diet - DHF; (3) normal diet + pummelo extract (50 mg/kg); and (4) FHD + pummelo extract. This was administered at dose of 50 mg/kg of the animal's weight, by gavage, for 45 days. Significant improvement in lipid profile, liver and kidney function, inflammation, oxidative stress markers was identified in group 4 compared to group 2. Regarding TNF-α and IL-1β, group 2 showed higher values (respectively 142, 5 ± 0.7 and 560.5 ± 2.7 pg/mg protein) compared to group 4 (respectively 91.4 ± 0.9 and 402.1.4 ± 0.9 pg/mg protein), p < 0.05. Significant increases were found in SOD and CAT activities, respectively 0.10 ± 0.06 and 8.62 ± 1.67 U/mg protein for group 2 and respectively 0.28 ± 0.08 and 21.52 ± 2.28 U/mg of protein for group 4. Decreases in triglycerides, hepatic cholesterol and fat droplets in hepatic tissue were observed in group 4 compared to group 2. Results highlight that pummelo extract may be useful for prevent the development of NAFLD. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0278-6915 1873-6351
DOI:	10.1016/j.fct.2023.113933