Search Results - "Casanova, M. Llanos"

A Transposon-based Analysis Reveals RASA1 Is Involved in Triple-Negative Breast Cancer by Suárez-Cabrera, Cristian, Quintana, Rita M, Bravo, Ana, Casanova, M Llanos, Page, Angustias, Alameda, Josefa P, Paramio, Jesús M, Maroto, Alicia, Salamanca, Javier, Dupuy, Adam J, Ramírez, Angel, Navarro, Manuel

“…RAS genes are mutated in 20% of human tumors, but these mutations are very rare in breast cancer. Here, we used a mouse model to generate tumors upon…”
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IKKα Induces Epithelial-Mesenchymal Changes in Mouse Skin Carcinoma Cells That Can Be Partially Reversed by Apigenin by García-García, Verónica A, Alameda, Josefa P, Page, Angustias, Mérida-García, Antonio, Navarro, Manuel, Tejero, Adrián, Paramio, Jesús M, García-Fernández, Rosa A, Casanova, M Llanos

“…NMSC (non-melanoma skin cancer) is a common tumor in the Caucasian population, accounting for 90% of skin cancers. Among them, squamous cell carcinomas (SCCs)…”
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The Ras-related gene ERAS is involved in human and murine breast cancer by Suárez-Cabrera, Cristian, de la Peña, Bárbara, González, Laura L., Page, Angustias, Martínez-Fernández, Mónica, Casanova, M. Llanos, Paramio, Jesús M., Rojo-Sebastián, Alejandro, Moreno-Bueno, Gema, Maroto, Alicia, Ramírez, Ángel, Navarro, Manuel

“…Although Ras genes are frequently mutated in human tumors, these mutations are uncommon in breast cancer. However, many breast tumors show evidences of Ras…”
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IKKβ overexpression together with a lack of tumour suppressor genes causes ameloblastic odontomas in mice by Page, Angustias, Bravo, Ana, Suarez-Cabrera, Cristian, Sanchez-Baltasar, Raquel, Oteo, Marta, Morcillo, Miguel Angel, Casanova, M. Llanos, Segovia, Jose C., Navarro, Manuel, Ramirez, Angel

“…Odontogenic tumours are a heterogeneous group of lesions that develop in the oral cavity region and are characterized by the formation of tumoural structures…”
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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors by Casanova, M Llanos, Blázquez, Cristina, Martínez-Palacio, Jesús, Villanueva, Concepción, Fernández-Aceñero, M Jesús, Huffman, John W, Jorcano, José L, Guzmán, Manuel

“…Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for the treatment of these tumors are currently…”
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IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf- Dependent by Page, Angustias, Bravo, Ana, Suarez-Cabrera, Cristian, Alameda, Josefa P, Casanova, M Llanos, Lorz, Corina, Segrelles, Carmen, Segovia, José C, Paramio, Jesús M, Navarro, Manuel, Ramirez, Angel

“…IKKβ (encoded by ) is a protein kinase that regulates the activity of numerous proteins important in several signaling pathways, such as the NF-κB pathway…”
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Premature aging and cancer development in transgenic mice lacking functional CYLD by Alameda, Josefa P, Ramírez, Ángel, García-Fernández, Rosa A, Navarro, Manuel, Page, Angustias, Segovia, José C, Sanchez, Rebeca, Suárez-Cabrera, Cristian, Paramio, Jesús M, Bravo, Ana, Fernández-Aceñero, M Jesús, Casanova, M Llanos

“…CYLD is a deubiquitinating enzyme known for its role as a tumor suppressor whose mutation leads to skin appendages tumors and other cancers. In this manuscript…”
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A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development by Quintana, Rita M., Dupuy, Adam J., Bravo, Ana, Casanova, M Llanos, Alameda, Josefa P., Page, Angustias, Sánchez-Viera, Miguel, Ramírez, Angel, Navarro, Manuel

“…Nonmelanoma skin cancer (NMSC) is by far the most frequent type of cancer in humans. NMSC includes several types of malignancies with different clinical…”
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Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas by BLAZQUEZ, Cristina, GONZALEZ-FERIA, Luis, ALVAREZ, Luis, HARO, Amador, CASANOVA, M. Llanos, GUZMAN, Manuel

“…Cannabinoids inhibit tumor angiogenesis in mice, but the mechanism of their antiangiogenic action is still unknown. Because the vascular endothelial growth…”
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Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53 by Page, Angustias, Navarro, Manuel, Suarez-Cabrera, Cristian, Alameda, Josefa P, Casanova, M Llanos, Paramio, Jesús M, Bravo, Ana, Ramirez, Angel

“…p53 is a protein that causes cell cycle arrest, apoptosis or senescence, being crucial in the process of tumor suppression in several cell types. Different in…”
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IKKα Promotes the Progression and Metastasis of Non-Small Cell Lung Cancer Independently of its Subcellular Localization by Page, Angustias, Ortega, Alba, Alameda, Josefa P., Navarro, Manuel, Paramio, Jesús M., Saiz-Pardo, Melchor, Almeida, Edilia I., Hernández, Pilar, Fernández-Aceñero, M. Jesús, García-Fernández, Rosa A., Casanova, M. Llanos

“…Lung cancer is the leading worldwide cause of cancer mortality, however, neither curative treatments nor substantial prolonged survival has been achieved,…”
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Functional Inactivation of CYLD Promotes the Metastatic Potential of Tumor Epidermal Cells by Alameda, Josefa P., Jesús Fernández-Aceñero, M., Quintana, Rita M., Page, Angustias, Ramírez, Ángel, Navarro, Manuel, Llanos Casanova, M.

“…CYLD is a tumor-suppressor gene mutated in the skin appendage tumors cylindromas, trichoepitheliomas, and spiradenomas. We have performed in vivo metastasis…”
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Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors by Alameda, Josefa P, Moreno-Maldonado, Rodolfo, Fernández-Aceñero, M Jesús, Navarro, Manuel, Page, Angustias, Jorcano, José L, Bravo, Ana, Ramírez, Ángel, Casanova, M Llanos

“…Non-melanoma skin cancer is the most frequent type of cancer in humans. In this study we demonstrate that elevated IKKα expression in murine epidermis…”
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IKKβ overexpression leads to pathologic lesions in stratified epithelia and exocrine glands and to tumoral transformation of oral epithelia by Page, Angustias, Cascallana, José L, Casanova, M Llanos, Navarro, Manuel, Alameda, Josefa P, Pérez, Paloma, Bravo, Ana, Ramírez, Angel

“…Alterations in nuclear factor kappaB (NFκB) signaling have been related with several diseases and importantly also with cancer. Different animal models with…”
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A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis by LLANOS CASANOVA, M, LARCHER, Fernando, CASANOVA, Benito, MURILLAS, Rodolfo, FERNANDEZ-ACENERO, M. Jesus, VILLANUEVA, Concepcion, MARTINEZ-PALACIO, Jesus, ULLRICH, Axel, CONTI, Claudio J, JORCANO, Jose Luis

“…Epidermal growth factor receptor (EGFR) plays a critical role in epidermal biology. Abnormal EGFR function has been described in epithelial tumors including…”
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Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones by Mashukova, Anastasia, Oriolo, Andrea S, Wald, Flavia A, Casanova, M Llanos, Kröger, Cornelia, Magin, Thomas M, Omary, M Bishr, Salas, Pedro J I

“…Atypical PKC (PKC iota) is a key organizer of cellular asymmetry. Sequential extractions of intestinal cells showed a pool of enzymatically active PKC iota and…”
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RNAi-Mediated Knockdown of IKK1 in Transgenic Mice Using a Transgenic Construct Containing the Human H1 Promoter by Casanova, M. Llanos, Bravo, Ana, Alameda, Josefa P., Suarez-Cabrera, Cristian, Page, Angustias, Navarro, Manuel, Murillas, Rodolfo, Moreno-Maldonado, Rodolfo, Ramirez, Angel

“…Inhibition of gene expression through siRNAs is a tool increasingly used for the study of gene function in model systems, including transgenic mice. To achieve…”
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Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8‐expressing transgenic mice by Casanova, M. Llanos, Bravo, Ana, Martínez‐Palacio, Jesús, Jesús Fernández‐Aceñero, M., Villanueva, Concepción, Larcher, Fernando, Conti, Claudio J., Jorcano, José L.

“…ABSTRACT Keratins K8 and K18 are the major components of the intermediate filament cytoskeleton of simple epithelia. Increased levels of these keratins have…”
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Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer by García-García, Verónica A., Alameda, Josefa P., Fernández-Aceñero, M. Jesús, Navarro, Manuel, García-Escudero, Ramón, Page, Angustias, Mateo-Gallego, Raúl, Paramio, Jesús M., Ramírez, Ángel, García-Fernández, Rosa A., Bravo, Ana, Casanova, M. Llanos

“…IKKα is known as an essential protein for skin homeostasis. However, the lack of suitable models to investigate its functions in the skin has led to IKKα being…”
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Inhibition of tumor angiogenesis by cannabinoids by Blázquez, Cristina, Casanova, M. Llanos, Planas, Anna, Gómez del Pulgar, Teresa, Villanueva, Concepción, Fernández‐Aceñero, María J., Aragonés, Julián, Huffman, John W., Jorcano, José L., Guzmán, Manuel

“…Cannabinoids, the active components of marijuana and their derivatives, induce tumor regression in rodents (8). However, the mechanism of cannabinoid…”
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