Search Results - "Casan, Joshua M. L."

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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Single-base tiled screen unveils design principles of PspCas13b for potent and off-target-free RNA silencing by Hu, Wenxin, Kumar, Amit, Ahmed, Syed Faraz, Qi, Shijiao, Ma, David K. G., Chen, Honglin, Singh, Gurjeet J., Casan, Joshua M. L., Haber, Michelle, Voskoboinik, Ilia, McKay, Matthew R., Trapani, Joseph A., Ekert, Paul G., Fareh, Mohamed

“…The development of precise RNA-editing tools is essential for the advancement of RNA therapeutics. CRISPR (clustered regularly interspaced short palindromic…”
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Degraders upgraded: the rise of PROTACs in hematological malignancies by Casan, Joshua M. L., Seymour, John F.

“…[Display omitted] Targeted protein degradation (TPD) is a revolutionary approach to targeted therapy in hematological malignancies that potentially circumvents…”
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Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care by Casan, Joshua ML, Barraclough, Alison, Shortt, Jake, Hawkes, Eliza A

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