Search Results - "Casalino, Simona"

Targeting KRAS: The Elephant in the Room of Epithelial Cancers by Merz, Valeria, Gaule, Marina, Zecchetto, Camilla, Cavaliere, Alessandro, Casalino, Simona, Pesoni, Camilla, Contarelli, Serena, Sabbadini, Fabio, Bertolini, Monica, Mangiameli, Domenico, Milella, Michele, Fedele, Vita, Melisi, Davide

“…Mutations of the proto-oncogene KRAS are the most frequent gain-of-function alterations found in cancer. KRAS is mutated in about 30% of all human tumors, but…”
Get full text

Integration of liposomal irinotecan in the first-line treatment of metastatic pancreatic cancer: try to do not think about the white bear by Melisi, Davide, Casalino, Simona, Pietrobono, Silvia, Quinzii, Alberto, Zecchetto, Camilla, Merz, Valeria

“…The approval of novel therapeutic agents remains widely reliant on evidence derived from large phase III randomized controlled trials. Liposomal irinotecan…”
Get full text

A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal–gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial by Merz, Valeria, Zecchetto, Camilla, Simionato, Francesca, Cavaliere, Alessandro, Casalino, Simona, Pavarana, Michele, Giacopuzzi, Simone, Bencivenga, Maria, Tomezzoli, Anna, Santoro, Raffaela, Fedele, Vita, Contarelli, Serena, Rossi, Irene, Giacomazzi, Serena, Pasquato, Martina, Piazzola, Cristiana, Milleri, Stefano, de Manzoni, Giovanni, Melisi, Davide

“…Background: Prognosis of patients affected by metastatic esophageal–gastric junction (EGJ) or gastric cancer (GC) remains dismal. Trastuzumab, an anti-HER2…”
Get full text

Role of next-generation genomic sequencing in targeted agents repositioning for pancreaticoduodenal cancer patients by Melisi, Davide, Cavaliere, Alessandro, Gobbo, Stefano, Fasoli, Giulia, Allegrini, Valentina, Simionato, Francesca, Gaule, Marina, Casalino, Simona, Pesoni, Camilla, Zecchetto, Camilla, Merz, Valeria, Mambrini, Andrea, Barbi, Emilio, Girelli, Roberto, Giardino, Alessandro, Frigerio, Isabella, Scalamogna, Roberto, Avitabile, Arianna, Castellani, Silvia, Milella, Michele, Butturini, Giovanni

“…Pancreaticoduodenal cancer (PDC) is a group of malignant tumors arising in the ampullary region, which lack approved targeted therapies for their treatment…”
Get full text

CCL3 predicts exceptional response to TGFβ inhibition in basal-like pancreatic cancer enriched in LIF-producing macrophages by Pietrobono, Silvia, Bertolini, Monica, De Vita, Veronica, Sabbadini, Fabio, Fazzini, Federica, Frusteri, Cristina, Scarlato, Enza, Mangiameli, Domenico, Quinzii, Alberto, Casalino, Simona, Zecchetto, Camilla, Merz, Valeria, Melisi, Davide

“…The TGFβ receptor inhibitor galunisertib showed promising efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) in the phase 2 H9H-MC-JBAJ study…”
Get full text

The role of nanoliposomal irinotecan plus fluorouracil/leucovorin in the continuum of care of patients with metastatic pancreatic ductal adenocarcinoma by Procaccio, Letizia, Merz, Valeria, Fasano, Morena, Vaccaro, Vanja, Giommoni, Elisa, Pretta, Andrea, Noventa, Silvia, Satolli, Maria Antonietta, Giordano, Guido, Zichi, Clizia, Pinto, Carmine, Zecchetto, Camilla, Barsotti, Giulia, De Vita, Ferdinando, Milella, Michele, Antonuzzo, Lorenzo, Scartozzi, Mario, Zaniboni, Alberto, Spadi, Rosella, Casalino, Simona, Bergamo, Francesca, De Toni, Chiara, Melisi, Davide, Lonardi, Sara

“…Background The NAPOLI‐I trial showed better outcome of nanoliposomal irinotecan (nal‐IRI) plus 5‐fluorouracil/leucovorin (5‐FU/LV) compared to 5‐FU/LV in…”
Get full text

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer by Cavaliere, Alessandro, Merz, Valeria, Casalino, Simona, Zecchetto, Camilla, Simionato, Francesca, Salt, Hayley Louise, Contarelli, Serena, Santoro, Raffaela, Melisi, Davide

“…Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and…”
Get full text

Predictive Biomarkers for a Personalized Approach in Resectable Pancreatic Cancer by Merz, Valeria, Mangiameli, Domenico, Zecchetto, Camilla, Quinzii, Alberto, Pietrobono, Silvia, Messina, Carlo, Casalino, Simona, Gaule, Marina, Pesoni, Camilla, Vitale, Pasquale, Trentin, Chiara, Frisinghelli, Michela, Caffo, Orazio, Melisi, Davide

“…The mainstay treatment for patients with immediate resectable pancreatic cancer remains upfront surgery, which represents the only potentially curative…”
Get full text

A phase II study of liposomal irinotecan with 5-fluorouracil, leucovorin and oxaliplatin in patients with resectable pancreatic cancer: the nITRO trial by Simionato, Francesca, Zecchetto, Camilla, Merz, Valeria, Cavaliere, Alessandro, Casalino, Simona, Gaule, Marina, D’Onofrio, Mirko, Malleo, Giuseppe, Landoni, Luca, Esposito, Alessandro, Marchegiani, Giovanni, Casetti, Luca, Tuveri, Massimiliano, Paiella, Salvatore, Scopelliti, Filippo, Giardino, Alessandro, Frigerio, Isabella, Regi, Paolo, Capelli, Paola, Gobbo, Stefano, Gabbrielli, Armando, Bernardoni, Laura, Fedele, Vita, Rossi, Irene, Piazzola, Cristiana, Giacomazzi, Serena, Pasquato, Martina, Gianfortone, Morena, Milleri, Stefano, Milella, Michele, Butturini, Giovanni, Salvia, Roberto, Bassi, Claudio, Melisi, Davide

“…Background: Up-front surgery followed by postoperative chemotherapy remains the standard paradigm for the treatment of patients with resectable pancreatic…”
Get full text

Novel Biomarkers for Prediction of Response to Preoperative Systemic Therapies in Gastric Cancer by Cavaliere, Alessandro, Merz, Valeria, Casalino, Simona, Zecchetto, Camilla, Simionato, Francesca, Salt, Hayley Louise, Contarelli, Serena, Santoro, Raffaela, Melisi, Davide

“…Preoperative chemo- and radiotherapeutic strategies followed by surgery are currently a standard approach for treating locally advanced gastric and…”
Get full text

Autotaxin Secretion Is a Stromal Mechanism of Adaptive Resistance to TGFβ Inhibition in Pancreatic Ductal Adenocarcinoma by Pietrobono, Silvia, Sabbadini, Fabio, Bertolini, Monica, Mangiameli, Domenico, De Vita, Veronica, Fazzini, Federica, Lunardi, Giulia, Casalino, Simona, Scarlato, Enza, Merz, Valeria, Zecchetto, Camilla, Quinzii, Alberto, Di Conza, Giusy, Lahn, Michael, Melisi, Davide

“…The TGFβ receptor inhibitor galunisertib demonstrated efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) in the randomized phase II H9H-MC-JBAJ…”
Get full text

nITRO: A phase 2 study of perioperative liposomal irinotecan + 5-fluorouracil/leucovorin + oxaliplatin (NALIRIFOX) in patients with resectable pancreatic ductal adenocarcinoma (rPDAC) by Melisi, Davide, Zecchetto, Camilla, Merz, Valeria, Malleo, Giuseppe, Landoni, Luca, Quinzii, Alberto, Casalino, Simona, Gaule, Marina, Pesoni, Camilla, Casetti, Luca, Esposito, Alessandro, Piazzola, Cristiana, D'Onofrio, Mirko, de Robertis, Riccardo, Gabbrielli, Armando, Luchini, Claudio, Butturini, Giovanni, Scarpa, Aldo, Salvia, Roberto, Bassi, Claudio

“…701 Background: Upfront surgery followed by adjuvant therapy is the standard treatment for patients with rPDAC. However, the risk of positive surgical margins,…”
Get full text

Perioperative NALIRIFOX in patients with resectable pancreatic ductal adenocarcinoma: The open-label, multicenter, phase II nITRO trial by Melisi, Davide, Zecchetto, Camilla, Merz, Valeria, Malleo, Giuseppe, Landoni, Luca, Quinzii, Alberto, Casalino, Simona, Fazzini, Federica, Gaule, Marina, Pesoni, Camilla, Casetti, Luca, Esposito, Alessandro, Marchegiani, Giovanni, Piazzola, Cristiana, D'Onofrio, Mirko, de Robertis, Riccardo, Gabbrielli, Armando, Bernardoni, Laura, Crino, Stefano F, Pietrobono, Silvia, Luchini, Claudio, Aliberti, Camillo, Martignoni, Guido, Milleri, Stefano, Butturini, Giovanni, Scarpa, Aldo, Salvia, Roberto, Bassi, Claudio

“…Upfront surgery followed by postoperative treatment is a commonly adopted treatment for resectable pancreatic ductal adenocarcinoma (rPDAC). However, the risk…”
Get full text

Clinical Response to Futibatinib in Patients with High-Level FGFR2-Amplified Advanced Gastric Cancer: Two Case Reports by Quinzii, Alberto, Zecchetto, Camilla, Casalino, Simona, Gaule, Marina, Pesoni, Camilla, Merz, Valeria, Contarelli, Serena, Pietrobono, Silvia, Benhadji, Karim A., Melisi, Davide

“…Genomic alterations responsible for a ligand-independent activation of these tyrosine kinases receptors, including activating point mutations, amplifications,…”
Get full text

A Novel EGFRvIII T-Cell Bispecific Antibody for the Treatment of Glioblastoma by Iurlaro, Raffaella, Waldhauer, Inja, Planas-Rigol, Ester, Bonfill-Teixidor, Ester, Arias, Alexandra, Nicolini, Valeria, Freimoser-Grundschober, Anne, Cuartas, Isabel, Martínez-Moreno, Alba, Martínez-Ricarte, Francisco, Cordero, Esteban, Cicuendez, Marta, Casalino, Simona, Guardia-Reyes, Xavier, Fahrni, Linda, Pöschinger, Thomas, Steinhart, Virginie, Richard, Marine, Briner, Stefanie, Mueller, Joerg, Osl, Franz, Sam, Johannes, Colombetti, Sara, Bacac, Marina, Klein, Christian, Pineda, Estela, Reyes-Figueroa, Luis, Di Somma, Alberto, González, Josep, Nuciforo, Paolo, Carles, Joan, Vieito, Maria, Tabernero, Josep, Umaña, Pablo, Seoane, Joan

“…T-cell bispecific antibodies (TCB) are engineered molecules that bind both the T-cell receptor and tumor-specific antigens. Epidermal growth factor receptor…”
Get full text

Organisational challenges, volumes of oncological activity and patients' perception during the severe acute respiratory syndrome coronavirus 2 epidemic by Zuliani, Serena, Zampiva, Ilaria, Tregnago, Daniela, Casali, Miriam, Cavaliere, Alessandro, Fumagalli, Arianna, Merler, Sara, Riva, Silvia Teresa, Rossi, Alice, Zacchi, Francesca, Zaninotto, Elisa, Auriemma, Alessandra, Pavarana, Michele, Soldà, Caterina, Benini, Lavinia, Borghesani, Michele, Caldart, Alberto, Casalino, Simona, Gaule, Marina, Kadrija, Dzenete, Mongillo, Marta, Pesoni, Camilla, Biondani, Pamela, Cingarlini, Sara, Fiorio, Elena, Melisi, Davide, Parolin, Veronica, Tondulli, Luca, Belluomini, Lorenzo, Zecchetto, Camilla, Avesani, Barbara, Biasi, Assunta, Bovo, Chiara, Dazzani, Elena, Dodi, Alessandra, Gelmini, Sara, Leta, Luigi Carmine, Lo Cascio, Giuliana, Lombardo, Fiorella, Lucin, Eleonora, Martinelli, Ilaria Asja, Messineo, Luisa, Moscarda, Viola, Pafumi, Sarah, Reni, Anna, Sartori, Giulia, Scaglione, Ilaria Mariangela, Shoval, Yiftach, Sposito, Marco, Tacconelli, Evelina, Trestini, Ilaria, Zambonin, Valentina, Zanelli, Sara, Pilotto, Sara, Milella, Michele

“…On February 23rd, the 1st case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was diagnosed at the University Hospital Trust of…”
Get full text

Multicenter Retrospective Analysis of Second-Line Therapy after Gemcitabine Plus Nab-Paclitaxel in Advanced Pancreatic Cancer Patients by Merz, Valeria, Cavaliere, Alessandro, Messina, Carlo, Salati, Massimiliano, Zecchetto, Camilla, Casalino, Simona, Milella, Michele, Caffo, Orazio, Melisi, Davide

“…Pancreatic cancer is one of the most lethal solid tumors. In many European countries gemcitabine plus nab-paclitaxel is the preferred first-line treatment. An…”
Get full text

Abstract 2495: CCL3 predicts an exceptional response to TGFβ inhibition in pancreatic ductal adenocarcinoma by sustaining a basal-like ecotype enriched in LIF-producing macrophages by Pietrobono, Silvia, Bertolini, Monica, De Vita, Veronica, Scarlato, Enza, Fazzini, Federica, Sabbadini, Fabio, Mangiameli, Domenico, Quinzii, Alberto, Casalino, Simona, Melisi, Davide

“…The TGFβ receptor inhibitor galunisertib (GAL) exhibited promising efficacy in patients with pancreatic ductal adenocarcinoma (PDAC) in the randomized phase 2…”
Get full text

Exceptional Clinical Response to Alectinib in Pancreatic Acinar Cell Carcinoma With a Novel ALK-KANK4 Gene Fusion by Gaule, Marina, Pesoni, Camilla, Quinzii, Alberto, Zecchetto, Camilla, Casalino, Simona, Merz, Valeria, Contarelli, Serena, Pietrobono, Silvia, Vissio, Elena, Molinaro, Luca, Manzin, Enrica, Volpatto, Roberta, Vellani, Giorgio, Melisi, Davide

Get more information

YAP Activation Is Associated with a Worse Prognosis of Poorly Cohesive Gastric Cancer by Bencivenga, Maria, Torroni, Lorena, Dal Cero, Mariagiulia, Quinzii, Alberto, Zecchetto, Camilla, Merz, Valeria, Casalino, Simona, Taus, Francesco, Pietrobono, Silvia, Mangiameli, Domenico, Filippini, Federica, Alloggio, Mariella, Castelli, Claudia, Iglesias, Mar, Pera, Manuel, Melisi, Davide

“…Poorly cohesive (PC) gastric cancer (GC) is extremely aggressive in progression, and there is an urgent need to identify the molecular pathways involved. We…”
Get full text