Search Results - "Casali, Paolo G."

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin by Germano, Giovanni, Frapolli, Roberta, Belgiovine, Cristina, Anselmo, Achille, Pesce, Samantha, Liguori, Manuela, Erba, Eugenio, Uboldi, Sarah, Zucchetti, Massimo, Pasqualini, Fabio, Nebuloni, Manuela, van Rooijen, Nico, Mortarini, Roberta, Beltrame, Luca, Marchini, Sergio, Fuso Nerini, Ilaria, Sanfilippo, Roberta, Casali, Paolo G., Pilotti, Silvana, Galmarini, Carlos M., Anichini, Andrea, Mantovani, Alberto, D’Incalci, Maurizio, Allavena, Paola

“…There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic…”
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Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis by Callegaro, Dario, MD, Miceli, Rosalba, PhD, Bonvalot, Sylvie, Prof, Ferguson, Peter, MD, Strauss, Dirk C, FRCS, Levy, Antonin, MD, Griffin, Anthony, MSc, Hayes, Andrew J, FRCS, Stacchiotti, Silvia, MD, Pechoux, Cecile Le, MD, Smith, Myles J, FRCSI, Fiore, Marco, MD, Dei Tos, Angelo P, MD, Smith, Henry G, MBBS, Mariani, Luigi, PhD, Wunder, Jay S, Prof, Pollock, Raphael E, Prof, Casali, Paolo G, MD, Gronchi, Alessandro, Dr

“…Summary Background The current American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system does not have sufficient…”
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Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial by Demetri, George D, Prof, Reichardt, Peter, Prof, Kang, Yoon-Koo, Prof, Blay, Jean-Yves, Prof, Rutkowski, Piotr, MD, Gelderblom, Hans, MD, Hohenberger, Peter, Prof, Leahy, Michael, FRCP, von Mehren, Margaret, Prof, Joensuu, Heikki, Prof, Badalamenti, Giuseppe, MD, Blackstein, Martin, FRCP, Le Cesne, Axel, MD, Schöffski, Patrick, Prof, Maki, Robert G, Prof, Bauer, Sebastian, MD, Nguyen, Binh Bui, MD, Xu, Jianming, MD, Nishida, Toshirou, MD, Chung, John, MD, Kappeler, Christian, PhD, Kuss, Iris, MD, Laurent, Dirk, MD, Casali, Paolo G, MD

“…Summary Background Until now, only imatinib and sunitinib have proven clinical benefit in patients with gastrointestinal stromal tumours (GIST), but almost all…”
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Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas) by Sanfilippo, Roberta, Jones, Robin L, Blay, Jean-Yves, Le Cesne, Axel, Provenzano, Salvatore, Antoniou, Georgios, Mir, Olivier, Fucà, Giovanni, Fumagalli, Elena, Bertulli, Rossella, Stacchiotti, Silvia, Brahmi, Mehdi, Grosso, Federica, Dufresne, Armelle, Hindi, Nadia, Sbaraglia, Marta, Gronchi, Alessandro, Collini, Paola, Dei Tos, Angelo P, Casali, Paolo G

“…Perivascular epitheliod cell tumors (PEComas) are rare mesenchymal neoplasms for which the role of systemic treatments is not established as there are no…”
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Rationale of the rare cancer list: a consensus paper from the Joint Action on Rare Cancers (JARC) of the European Union (EU) by Casali, Paolo G, Trama, Annalisa

“…BackgroundThe Surveillance of Rare Cancers in Europe (RARECARE) project proposed a definition and a list of rare cancers. The Joint Action on Rare Cancers…”
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Personalizing the Approach to Retroperitoneal Soft Tissue Sarcoma: Histology-specific Patterns of Failure and Postrelapse Outcome after Primary Extended Resection by Gronchi, Alessandro, Miceli, Rosalba, Allard, Marc Antoine, Callegaro, Dario, Le Péchoux, Cecile, Fiore, Marco, Honoré, Charles, Sanfilippo, Roberta, Coppola, Sara, Stacchiotti, Silvia, Terrier, Philippe, Casali, Paolo G., Le Cesne, Axel, Mariani, Luigi, Colombo, Chiara, Bonvalot, Sylvie

“…Purpose To explore patterns of failure and postrelapse outcome of patients with retroperitoneal sarcoma primarily treated by extended resection. Methods All…”
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Sacral Chordoma: Long-term Outcome of a Large Series of Patients Surgically Treated at Two Reference Centers by Radaelli, Stefano, Stacchiotti, Silvia, Ruggieri, Pietro, Donati, Davide, Casali, Paolo G., Palmerini, Emanuela, Collini, Paola, Gambarotti, Marco, Porcu, Luca, Boriani, Stefano, Gronchi, Alessandro, Picci, Piero

“…STUDY DESIGN.Retrospective case series. OBJECTIVE.To report on the natural history and long-term outcome of a large series of consecutive primary sacral…”
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Post‐relapse outcomes after primary extended resection of retroperitoneal sarcoma: A report from the Trans‐Atlantic RPS Working Group by MacNeill, Andrea J., Miceli, Rosalba, Strauss, Dirk C., Bonvalot, Sylvie, Hohenberger, Peter, Coevorden, Frits, Rutkowski, Piotr, Callegaro, Dario, Hayes, Andrew J., Honoré, Charles, Fairweather, Mark, Cannell, Amanda, Jakob, Jens, Haas, Rick L., Szacht, Milena, Fiore, Marco, Casali, Paolo G., Pollock, Raphael E., Raut, Chandrajit P., Gronchi, Alessandro, Swallow, Carol J.

“…BACKGROUND Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The…”
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Networking in rare cancers: What was done, what's next by Frezza, Anna Maria, Trama, Annalisa, Blay, Jean-Yves, Casali, Paolo G.

“…Rare cancers represent approximately one fourth of all cancers. Despite being a heterogeneous group of diseases, they share similar problems including lack of…”
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Myogenic Differentiation and Histologic Grading Are Major Prognostic Determinants in Retroperitoneal Liposarcoma by Gronchi, Alessandro, Collini, Paola, Miceli, Rosalba, Valeri, Barbara, Renne, Salvatore L, Dagrada, Gianpaolo, Fiore, Marco, Sanfilippo, Roberta, Barisella, Marta, Colombo, Chiara, Morosi, Carlo, Stacchiotti, Silvia, Casali, Paolo G, Dei Tos, Angelo P, Pilotti, Silvana

“…The aim of the present work was to improve the understanding of the impact of malignancy grade and myogenic/rhabdomyoblastic differentiation on the natural…”
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Desmoid-Type Fibromatosis: A Front-Line Conservative Approach to Select Patients for Surgical Treatment by Fiore, Marco, Rimareix, Françoise, Mariani, Luigi, Domont, Julien, Collini, Paola, Le Péchoux, Cecile, Casali, Paolo G., Le Cesne, Axel, Gronchi, Alessandro, Bonvalot, Sylvie

“…Purpose Surgery is still the standard treatment for desmoid-type fibromatosis (DF). Recently, the Institut Gustave Roussy (IGR), Villejuif, France, reported a…”
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Myxofibrosarcoma: Prognostic Factors and Survival in a Series of Patients Treated at a Single Institution by Sanfilippo, Roberta, Miceli, Rosalba, Grosso, Federica, Fiore, Marco, Puma, Elisa, Pennacchioli, Elisabetta, Barisella, Marta, Sangalli, Claudia, Mariani, Luigi, Casali, Paolo G., Gronchi, Alessandro

“…Background First described in 1977, myxofibrosarcoma is one of the most common sarcoma subtypes of the elderly. Until some years ago, myxofibrosarcoma was…”
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Imatinib in advanced chordoma: A retrospective case series analysis by Hindi, Nadia, Casali, Paolo G, Morosi, Carlo, Messina, Antonella, Palassini, Elena, Pilotti, Silvana, Tamborini, Elena, Radaelli, Stefano, Gronchi, Alessandro, Stacchiotti, Silvia

“…Abstract Introduction Imatinib showed activity in 50 chordoma patients treated within a Phase II study. In that study, 70% of patients remained with stable…”
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Neoadjuvant Imatinib in Locally Advanced Gastrointestinal Stromal Tumors (GIST): The EORTC STBSG Experience by Rutkowski, Piotr, Gronchi, Alessandro, Hohenberger, Peter, Bonvalot, Sylvie, Schöffski, Patrick, Bauer, Sebastian, Fumagalli, Elena, Nyckowski, Pawel, Nguyen, Buu-Phuc, Kerst, Jan Martijn, Fiore, Marco, Bylina, Elzbieta, Hoiczyk, Mathias, Cats, Annemieke, Casali, Paolo G., Le Cesne, Axel, Treckmann, Jürgen, Stoeckle, Eberhard, de Wilt, Johannes. H. W., Sleijfer, Stefan, Tielen, Ronald, van der Graaf, Winette, Verhoef, Cornelis, van Coevorden, Frits

“…Background Preoperative imatinib therapy of locally advanced GIST may facilitate resection and decrease morbidity of the procedure. Methods We have pooled…”
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Activity of Pazopanib and Trabectedin in Advanced Alveolar Soft Part Sarcoma by Stacchiotti, Silvia, Mir, Olivier, Le Cesne, Axel, Vincenzi, Bruno, Fedenko, Alexander, Maki, Robert G., Somaiah, Neeta, Patel, Shreyaskumar, Brahmi, Mehedi, Blay, Jean Y., Boye, Kjetil, Sundby Hall, Kirsten, Gelderblom, Hans, Hindi, Nadia, Martin‐Broto, Javier, Kosela, Hanna, Rutkowski, Piotr, Italiano, Antoine, Duffaud, Florence, Kobayashi, Eisuke, Casali, Paolo G., Provenzano, Salvatore, Kawai, Akira

“…Background Alveolar soft part sarcoma (ASPS) is an exceedingly rare and orphan disease, without active drugs approved in the front line. Pazopanib and…”
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Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells by GERMANO, Giovanni, FRAPOLLI, Roberta, GRONCHI, Alessandro, VIRDIS, Emanuela, TARANTINO, Eva, PILOTTI, Silvana, GRECO, Angela, NEBULONI, Manuela, GALMARINI, Carlos Maria, TERCERO, Juan Carlos, MANTOVANI, Alberto, D'INCALCI, Maurizio, SIMONE, Matteo, ALLAVENA, Paola, TAVECCHIO, Michele, ERBA, Eugenio, PESCE, Samantha, PASQUALINI, Fabio, GROSSO, Federica, SANFILIPPO, Roberta, CASALI, Paolo G

“…Inflammatory mediators present in the tumor milieu may promote cancer progression and are considered promising targets of novel biological therapies. We…”
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Quality of Surgery and Outcome in Localized Gastrointestinal Stromal Tumors Treated Within an International Intergroup Randomized Clinical Trial of Adjuvant Imatinib by Gronchi, Alessandro, Bonvalot, Sylvie, Poveda Velasco, Andres, Kotasek, Dusan, Rutkowski, Piotr, Hohenberger, Peter, Fumagalli, Elena, Judson, Ian R, Italiano, Antoine, Gelderblom, Hans J, van Coevorden, Frits, Penel, Nicolas, Kopp, Hans-Georg, Duffaud, Florence, Goldstein, David, Broto, Javier Martin, Wardelmann, Eva, Marréaud, Sandrine, Smithers, Mark, Le Cesne, Axel, Zaffaroni, Facundo, Litière, Saskia, Blay, Jean-Yves, Casali, Paolo G

“…The association between quality of surgery and overall survival in patients affected by localized gastrointestinal stromal tumors (GIST) is not completely…”
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Efficacy and Biological Activity of Imatinib in Metastatic Dermatofibrosarcoma Protuberans (DFSP) by Stacchiotti, Silvia, Pantaleo, Maria A, Negri, Tiziana, Astolfi, Annalisa, Tazzari, Marcella, Dagrada, Gian Paolo, Urbini, Milena, Indio, Valentina, Maestro, Roberta, Gronchi, Alessandro, Fiore, Marco, Dei Tos, Angelo P, Conca, Elena, Palassini, Elena, Vincenzi, Bruno, Grosso, Federica, Pilotti, Silvana, Castelli, Chiara, Casali, Paolo G

“…To report on imatinib mesylate (IM) in patients with metastatic dermatofibrosarcoma protuberans (DFSP)/fibrosarcomatous (FS)-DFSP and on the impact of the…”
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Sirolimus in Advanced Epithelioid Hemangioendothelioma: A Retrospective Case-Series Analysis from the Italian Rare Cancer Network Database by Stacchiotti, Silvia, Provenzano, Salvatore, Dagrada, Gianpaolo, Negri, Tiziana, Brich, Silvia, Basso, Umberto, Brunello, Antonella, Grosso, Federica, Galli, Luca, Palassini, Elena, Libertini, Michela, Colia, Vittoria, Gronchi, Alessandro, Dei Tos, Angelo P., Crippa, Flavio, Morosi, Carlo, Pilotti, Silvana, Casali, Paolo G.

“…Background The aim of this study was to report on sirolimus activity in a series of patients with hemangioendothelioma (HE) treated at the National Cancer…”
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Ethical issues in oncology practice: a qualitative study of stakeholders’ experiences and expectations by Crico, Chiara, Sanchini, Virginia, Casali, Paolo G, Pravettoni, Gabriella

“…Abstract Background Clinical Ethics Support Services (CESS) have been established to support healthcare professionals in addressing ethically sensitive issues…”
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