Search Results - "Casali, Paolo"

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin by Germano, Giovanni, Frapolli, Roberta, Belgiovine, Cristina, Anselmo, Achille, Pesce, Samantha, Liguori, Manuela, Erba, Eugenio, Uboldi, Sarah, Zucchetti, Massimo, Pasqualini, Fabio, Nebuloni, Manuela, van Rooijen, Nico, Mortarini, Roberta, Beltrame, Luca, Marchini, Sergio, Fuso Nerini, Ilaria, Sanfilippo, Roberta, Casali, Paolo G., Pilotti, Silvana, Galmarini, Carlos M., Anichini, Andrea, Mantovani, Alberto, D’Incalci, Maurizio, Allavena, Paola

“…There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic…”
Get full text

Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis by Callegaro, Dario, MD, Miceli, Rosalba, PhD, Bonvalot, Sylvie, Prof, Ferguson, Peter, MD, Strauss, Dirk C, FRCS, Levy, Antonin, MD, Griffin, Anthony, MSc, Hayes, Andrew J, FRCS, Stacchiotti, Silvia, MD, Pechoux, Cecile Le, MD, Smith, Myles J, FRCSI, Fiore, Marco, MD, Dei Tos, Angelo P, MD, Smith, Henry G, MBBS, Mariani, Luigi, PhD, Wunder, Jay S, Prof, Pollock, Raphael E, Prof, Casali, Paolo G, MD, Gronchi, Alessandro, Dr

“…Summary Background The current American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system does not have sufficient…”
Get full text

B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids by Sanchez, Helia N., Moroney, Justin B., Gan, Huoqun, Shen, Tian, Im, John L., Li, Tianbao, Taylor, Julia R., Zan, Hong, Casali, Paolo

“…Short-chain fatty acids (SCFAs) butyrate and propionate are metabolites from dietary fiber's fermentation by gut microbiota that can affect differentiation or…”
Get full text

Immunoglobulin class-switch DNA recombination: induction, targeting and beyond by Xu, Zhenming, Zan, Hong, Pone, Egest J., Mai, Thach, Casali, Paolo

“…Key Points T cell-dependent and T cell-independent primary class-switch DNA recombination (CSR)-inducing stimuli induce activation-induced cytidine deaminase…”
Get full text

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial by Demetri, George D, Prof, Reichardt, Peter, Prof, Kang, Yoon-Koo, Prof, Blay, Jean-Yves, Prof, Rutkowski, Piotr, MD, Gelderblom, Hans, MD, Hohenberger, Peter, Prof, Leahy, Michael, FRCP, von Mehren, Margaret, Prof, Joensuu, Heikki, Prof, Badalamenti, Giuseppe, MD, Blackstein, Martin, FRCP, Le Cesne, Axel, MD, Schöffski, Patrick, Prof, Maki, Robert G, Prof, Bauer, Sebastian, MD, Nguyen, Binh Bui, MD, Xu, Jianming, MD, Nishida, Toshirou, MD, Chung, John, MD, Kappeler, Christian, PhD, Kuss, Iris, MD, Laurent, Dirk, MD, Casali, Paolo G, MD

“…Summary Background Until now, only imatinib and sunitinib have proven clinical benefit in patients with gastrointestinal stromal tumours (GIST), but almost all…”
Get full text

Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: a non-randomised phase 2 clinical trial by Grignani, Giovanni, Dr, Palmerini, Emanuela, MD, Ferraresi, Virginia, MD, D'Ambrosio, Lorenzo, MD, Bertulli, Rossella, MD, Asaftei, Sebastian Dorin, MD, Tamburini, Angela, MD, Pignochino, Ymera, PhD, Sangiolo, Dario, PhD, Marchesi, Emanuela, PhD, Capozzi, Federica, BSc, Biagini, Roberto, MD, Gambarotti, Marco, MD, Fagioli, Franca, MD, Casali, Paolo Giovanni, MD, Picci, Piero, MD, Ferrari, Stefano, MD, Aglietta, Massimo, Prof

“…Summary Background Results of previous study showed promising but short-lived activity of sorafenib in the treatment of patients with unresectable advanced and…”
Get full text

Variability in Patterns of Recurrence After Resection of Primary Retroperitoneal Sarcoma (RPS): A Report on 1007 Patients From the Multi-institutional Collaborative RPS Working Group by Gronchi, Alessandro, Strauss, Dirk C, Miceli, Rosalba, Bonvalot, Sylvie, Swallow, Carol J, Hohenberger, Peter, Van Coevorden, Frits, Rutkowski, Piotr, Callegaro, Dario, Hayes, Andrew J, Honoré, Charles, Fairweather, Mark, Cannell, Amanda, Jakob, Jens, Haas, Rick L, Szacht, Milena, Fiore, Marco, Casali, Paolo G, Pollock, Raphael E, Raut, Chandrajit P

“…BACKGROUND:Retroperitoneal sarcomas (RPS) are rare tumors composed of several well defined histologic subtypes. The aim of this study was to analyze patterns…”
Get full text

A prospective observational study of Active surveillance in primary desmoid fibromatosis by Colombo, Chiara, Fiore, Marco, Grignani, Giovanni, Tolomeo, Francesco, Merlini, Alessandra, Palassini, Elena, Collini, Paola, Stacchiotti, Silvia, Casali, Paolo G, Perrone, Federica, Mariani, Luigi, Gronchi, Alessandro

“…To prospectively assess the behaviour of primary sporadic (not FAP associated) desmoid fibromatosis (DF) managed by active surveillance (AS). This is an…”
Get full text

The impact of chemotherapy on survival of patients with extremity and trunk wall soft tissue sarcoma: revisiting the results of the EORTC-STBSG 62931 randomised trial by Pasquali, Sandro, Pizzamiglio, Sara, Touati, Nathan, Litiere, Saskia, Marreaud, Sandrine, Kasper, Bernd, Gelderblom, Hans, Stacchiotti, Silvia, Judson, Ian, Dei Tos, Angelo P., Verderio, Paolo, Casali, Paolo G., Woll, Penella J., Gronchi, Alessandro

“…This study was aimed at determining whether patients with high-risk soft tissue sarcoma (STS), as identified using the nomogram Sarculator, benefitted from…”
Get full text

Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high‐grade lesions by Corino, Valentina D.A., Montin, Eros, Messina, Antonella, Casali, Paolo G., Gronchi, Alessandro, Marchianò, Alfonso, Mainardi, Luca T.

“…Purpose To assess the feasibility of grading soft tissue sarcomas (STSs) using MRI features (radiomics). Materials and Methods MRI (echo planar SE, 1.5T) from…”
Get full text

Role of Chemotherapy, VEGFR Inhibitors, and mTOR Inhibitors in Advanced Perivascular Epithelioid Cell Tumors (PEComas) by Sanfilippo, Roberta, Jones, Robin L, Blay, Jean-Yves, Le Cesne, Axel, Provenzano, Salvatore, Antoniou, Georgios, Mir, Olivier, Fucà, Giovanni, Fumagalli, Elena, Bertulli, Rossella, Stacchiotti, Silvia, Brahmi, Mehdi, Grosso, Federica, Dufresne, Armelle, Hindi, Nadia, Sbaraglia, Marta, Gronchi, Alessandro, Collini, Paola, Dei Tos, Angelo P, Casali, Paolo G

“…Perivascular epitheliod cell tumors (PEComas) are rare mesenchymal neoplasms for which the role of systemic treatments is not established as there are no…”
Get full text

Rationale of the rare cancer list: a consensus paper from the Joint Action on Rare Cancers (JARC) of the European Union (EU) by Casali, Paolo G, Trama, Annalisa

“…BackgroundThe Surveillance of Rare Cancers in Europe (RARECARE) project proposed a definition and a list of rare cancers. The Joint Action on Rare Cancers…”
Get full text

(Neo)adjuvant treatment in localised soft tissue sarcoma: The unsolved affair by Saponara, Maristella, Stacchiotti, Silvia, Casali, Paolo G, Gronchi, Alessandro

“…Abstract Soft tissue sarcomas (STS) are rare and heterogeneous tumours. A correct definition of STS is imperative from the very beginning of disease…”
Get full text

Impact of perioperative chemotherapy and radiotherapy in patients with primary extremity soft tissue sarcoma: retrospective analysis across major histological subtypes and major reference centres by Callegaro, Dario, Miceli, Rosalba, Bonvalot, Sylvie, Ferguson, Peter, Strauss, Dirk C., Levy, Antonin, Griffin, Anthony, Hayes, Andrew J., Stacchiotti, Silvia, Le Pèchoux, Cecile, Smith, Myles J., Fiore, Marco, Dei Tos, Angelo Paolo, Smith, Henry G., Catton, Charles, Casali, Paolo G., Wunder, Jay S., Gronchi, Alessandro

“…The role of radiotherapy (RTx) and chemotherapy (CTx) in primary extremity soft tissue sarcoma (eSTS) patients is not precisely defined. All consecutive…”
Get full text

Phase II Study of Imatinib in Advanced Chordoma by STACCHIOTTI, Silvia, LONGHI, Alessandra, SPREAFICO, Carlo, GRONCHI, Alessandro, AMORE, Paola, VINACCIA, Vincenza, GIOVANNI CASALI, Paolo, FERRARESI, Virginia, GRIGNANI, Giovanni, COMANDONE, Alessandro, STUPP, Roger, BERTUZZI, Alexia, TAMBORINI, Elena, PILOTTI, Silvana, MESSINA, Antonella

“…To explore the antitumor activity of imatinib in patients with advanced platelet-derived growth factor β (PDGFB)/PDGF receptor β (PDGFRB)-positive chordomas…”
Get full text

Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response by Zan, Hong, Casali, Paolo

“…Epigenetic modifications, such as histone post-translational modifications, DNA methylation, and alteration of gene expression by non-coding RNAs, including…”
Get full text

Personalizing the Approach to Retroperitoneal Soft Tissue Sarcoma: Histology-specific Patterns of Failure and Postrelapse Outcome after Primary Extended Resection by Gronchi, Alessandro, Miceli, Rosalba, Allard, Marc Antoine, Callegaro, Dario, Le Péchoux, Cecile, Fiore, Marco, Honoré, Charles, Sanfilippo, Roberta, Coppola, Sara, Stacchiotti, Silvia, Terrier, Philippe, Casali, Paolo G., Le Cesne, Axel, Mariani, Luigi, Colombo, Chiara, Bonvalot, Sylvie

“…Purpose To explore patterns of failure and postrelapse outcome of patients with retroperitoneal sarcoma primarily treated by extended resection. Methods All…”
Get full text

Ten-Year Progression-Free and Overall Survival in Patients With Unresectable or Metastatic GI Stromal Tumors: Long-Term Analysis of the European Organisation for Research and Treatment of Cancer, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group Intergroup Phase III Randomized Trial on Imatinib at Two Dose Levels by Casali, Paolo G, Zalcberg, John, Le Cesne, Axel, Reichardt, Peter, Blay, Jean-Yves, Lindner, Lars H, Judson, Ian R, Schöffski, Patrick, Leyvraz, Serge, Italiano, Antoine, Grünwald, Viktor, Pousa, Antonio Lopez, Kotasek, Dusan, Sleijfer, Stefan, Kerst, Jan M, Rutkowski, Piotr, Fumagalli, Elena, Hogendoorn, Pancras, Litière, Saskia, Marreaud, Sandrine, van der Graaf, Winette, Gronchi, Alessandro, Verweij, Jaap

“…Purpose To report on the long-term results of a randomized trial comparing a standard dose (400 mg/d) versus a higher dose (800 mg/d) of imatinib in patients…”
Get full text

Postoperative Morbidity After Radical Resection of Primary Retroperitoneal Sarcoma: A Report From the Transatlantic RPS Working Group by MacNeill, Andrea J, Gronchi, Alessandro, Miceli, Rosalba, Bonvalot, Sylvie, Swallow, Carol J, Hohenberger, Peter, Van Coevorden, Frits, Rutkowski, Piotr, Callegaro, Dario, Hayes, Andrew J, Honoré, Charles, Fairweather, Mark, Cannell, Amanda, Jakob, Jens, Haas, Rick L, Szacht, Milena, Fiore, Marco, Casali, Paolo G, Pollock, Raphael E, Barretta, Francesco, Raut, Chandrajit P, Strauss, Dirk C

“…OBJECTIVE:To investigate the safety of radical resection for retroperitoneal sarcoma (RPS). BACKGROUND:The surgical management of RPS frequently involves…”
Get full text

Sacral Chordoma: Long-term Outcome of a Large Series of Patients Surgically Treated at Two Reference Centers by Radaelli, Stefano, Stacchiotti, Silvia, Ruggieri, Pietro, Donati, Davide, Casali, Paolo G., Palmerini, Emanuela, Collini, Paola, Gambarotti, Marco, Porcu, Luca, Boriani, Stefano, Gronchi, Alessandro, Picci, Piero

“…STUDY DESIGN.Retrospective case series. OBJECTIVE.To report on the natural history and long-term outcome of a large series of consecutive primary sacral…”
Get full text