Search Results - "Casal, Ignacio"

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer by TORRES, Sofia, BARTOLOME, Rubén A, BONILLA, Felix, IGNACIO CASAL, J, MENDES, Marta, BARDERAS, Rodrigo, FERNANDEZ-ACENERO, M. Jesus, PELAEZ-GARCIA, Alberto, PENA, Cristina, LOPEZ-LUCENDO, María, VILLAR-VAZQUEZ, Roi, GARCIA DE HERREROS, Antonio

“…Cancer-associated fibroblasts (CAF) are essential components of the stroma that play a critical role in cancer progression. This study aimed to identify novel…”
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Beyond N-Cadherin, Relevance of Cadherins 5, 6 and 17 in Cancer Progression and Metastasis by Casal, J Ignacio, Bartolomé, Rubén A

“…Cell-cell adhesion molecules (cadherins) and cell-extracellular matrix adhesion proteins (integrins) play a critical role in the regulation of cancer invasion…”
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High Expression of IL-13 Receptor α2 in Colorectal Cancer Is Associated with Invasion, Liver Metastasis, and Poor Prognosis by BARDERAS, Rodrigo, BARTOLOME, Rubén A, FERNANDEZ-ACENERO, Maria Jesús, TORRES, Sofia, IGNACIO CASAL, J

“…Autocrine secretion of cytokines by metastatic colorectal cancer cells and their role during invasion and liver homing has been poorly characterized. In this…”
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Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation by Robles, Javier, Prakash, Ananth, Vizcaíno, Juan Antonio, Casal, J Ignacio

“…The cancer biomarker field has been an object of thorough investigation in the last decades. Despite this, colorectal cancer (CRC) heterogeneity makes it…”
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Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma by Rodrigo, Miguel Angel Merlos, Michalkova, Hana, Strmiska, Vladislav, Casar, Berta, Crespo, Piero, de los Rios, Vivian, Ignacio Casal, J., Haddad, Yazan, Guran, Roman, Eckschlager, Tomas, Pokorna, Petra, Heger, Zbynek, Adam, Vojtech

“…Metallothionein-3 has poorly characterized functions in neuroblastoma. Cisplatin-based chemotherapy is a major regimen to treat neuroblastoma, but its clinical…”
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Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis by Alba-Castellón, Lorena, Olivera-Salguero, Rubén, Mestre-Farrera, Aida, Peña, Raúl, Herrera, Mercedes, Bonilla, Félix, Casal, J Ignacio, Baulida, Josep, Peña, Cristina, García de Herreros, Antonio

“…Snail1 transcriptional factor is essential for triggering epithelial-to-mesenchymal transition (EMT) and inducing tumor cell invasion. We report here an…”
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FGFR4 role in epithelial-mesenchymal transition and its therapeutic value in colorectal cancer by Peláez-García, Alberto, Barderas, Rodrigo, Torres, Sofía, Hernández-Varas, Pablo, Teixidó, Joaquín, Bonilla, Félix, de Herreros, Antonio Garcia, Casal, J Ignacio

“…Fibroblast growth factor receptor 4 (FGFR4) is vital in early development and tissue repair. FGFR4 expression levels are very restricted in adult tissues,…”
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Interleukin 13 receptor alpha 2 (IL13Rα2): Expression, signaling pathways and therapeutic applications in cancer by Jaén, Marta, Martín-Regalado, Ángela, Bartolomé, Rubén A., Robles, Javier, Casal, J. Ignacio

“…Interleukin 13 receptor alpha 2 (IL13Rα2) is increasingly recognized as a relevant player in cancer invasion and metastasis. Despite being initially considered…”
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Cancer‐associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients by Herrera, Mercedes, Herrera, Alberto, Domínguez, Gemma, Silva, Javier, García, Vanesa, García, José M., Gómez, Irene, Soldevilla, Beatriz, Muñoz, Concepción, Provencio, Mariano, Campos‐Martin, Yolanda, García de Herreros, Antonio, Casal, Ignacio, Bonilla, Félix, Peña, Cristina

“…Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the…”
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LOXL2 Is Highly Expressed in Cancer-Associated Fibroblasts and Associates to Poor Colon Cancer Survival by Torres, Sofía, Garcia-Palmero, Irene, Herrera, Mercedes, Bartolomé, Rubén A, Peña, Cristina, Fernandez-Aceñero, M Jesús, Padilla, Guillermo, Peláez-García, Alberto, Lopez-Lucendo, María, Rodriguez-Merlo, Rufo, García de Herreros, Antonio, Bonilla, Félix, Casal, J Ignacio

“…Cancer-associated fibroblasts (CAF) are major mediators in tumor microenvironment. We investigated the changes in protein expression in colon cancer-associated…”
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In-depth Characterization of the Secretome of Colorectal Cancer Metastatic Cells Identifies Key Proteins in Cell Adhesion, Migration, and Invasion by Barderas, Rodrigo, Mendes, Marta, Torres, Sofia, Bartolomé, Rubén A., López-Lucendo, María, Villar-Vázquez, Roi, Peláez-García, Alberto, Fuente, Eduardo, Bonilla, Félix, Casal, J. Ignacio

“…Liver metastasis in colorectal cancer is the major cause of cancer-related deaths. To identify and characterize proteins associated with colon cancer…”
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An IL13Rα2 peptide exhibits therapeutic activity against metastatic colorectal cancer by Bartolomé, Rubén A., Jaén, Marta, Casal, J. Ignacio

“…Background Interleukin 13 receptor α2 (IL13Rα2) is overexpressed in metastatic colorectal cancer. Here, we have developed novel strategies to block IL-13…”
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Monoclonal Antibodies Directed against Cadherin RGD Exhibit Therapeutic Activity against Melanoma and Colorectal Cancer Metastasis by Bartolomé, Rubén A, Aizpurua, Carmen, Jaén, Marta, Torres, Sofía, Calviño, Eva, Imbaud, Juan I, Casal, J Ignacio

“…New targets are required for the control of advanced metastatic disease. We investigated the use of cadherin RGD motifs, which activate the α2β1integrin…”
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SOSTDC1 promotes invasion and liver metastasis in colorectal cancer via interaction with ALCAM/CD166 by Bartolomé, Rubén A., Pintado-Berninches, Laura, Jaén, Marta, de Los Ríos, Vivian, Imbaud, Juan Ignacio, Casal, J. Ignacio

“…The mechanistic basis of liver metastasis in colorectal cancer remains poorly understood. We previously reported that the sclerostin domain containing-1…”
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Identification of Tumor-associated Autoantigens for the Diagnosis of Colorectal Cancer in Serum Using High Density Protein Microarrays by Babel, Ingrid, Barderas, Rodrigo, Díaz-Uriarte, Ramón, Martínez-Torrecuadrada, Jorge Luis, Sánchez-Carbayo, Marta, Casal, J. Ignacio

“…There is a mounting evidence of the existence of autoantibodies associated to cancer progression. Antibodies are the target of choice for serum screening…”
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Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer by Soler, Maria, Estevez, M.-Carmen, Villar-Vazquez, Roi, Casal, J. Ignacio, Lechuga, Laura M.

“…Colorectal cancer is treatable and curable when detected at early stages. However there is a lack of less invasive and more specific screening and diagnosis…”
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Development of a novel multiplex beads-based assay for autoantibody detection for colorectal cancer diagnosis by Villar-Vázquez, Roi, Padilla, Guillermo, Fernández-Aceñero, María Jesús, Suárez, Adolfo, Fuente, Eduardo, Pastor, Carlos, Calero, Miguel, Barderas, Rodrigo, Casal, J. Ignacio

“…Humoral response in cancer patients can be used for early cancer detection. By screening high‐density protein microarrays with sera from colorectal cancer…”
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An RGD Motif Present in Cadherin 17 Induces Integrin Activation and Tumor Growth by Bartolomé, Rubén A., Peláez-García, Alberto, Gomez, Inmaculada, Torres, Sofía, Fernandez-Aceñero, María Jesús, Escudero-Paniagua, Beatriz, Imbaud, J. Ignacio, Casal, J. Ignacio

“…Little is known about the mechanism of integrin activation by cadherin 17 (CDH17). Here we observed the presence of a tri-peptide motif, RGD, in domain 6 of…”
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Affinity maturation of antibodies assisted by in silico modeling by Barderas, Rodrigo, Desmet, Johan, Timmerman, Peter, Meloen, Rob, Casal, J. Ignacio

“…Rational engineering methods can be applied with reasonable success to optimize physicochemical characteristics of proteins, in particular, antibodies. Here,…”
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Cohesin organizes chromatin loops at DNA replication factories by Guillou, Emmanuelle, Ibarra, Arkaitz, Coulon, Vincent, Casado-Vela, Juan, Rico, Daniel, Casal, Ignacio, Schwob, Etienne, Losada, Ana, Méndez, Juan

“…Genomic DNA is packed in chromatin fibers organized in higher-order structures within the interphase nucleus. One level of organization involves the formation…”
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