Search Results - "Casacó, Angel"

Radiosensitization induced by the anti-epidermal growth factor receptor monoclonal antibodies cetuximab and nimotuzumab in A431 cells by González, Jorge Ernesto, Barquinero, Joan Francesc, Lee, Manuel, García, Omar, Casacó, Angel

“…Epidermal growth factor receptors (EGFR) are overexpressed in a wide range of malignancies including head and neck, colon, and breast cancers. It has been…”
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Safety and Immunogenicity of a Human Epidermal Growth Factor Receptor 1 (HER1)-Based Vaccine in Prostate Castration-Resistant Carcinoma Patients: A Dose-Escalation Phase I Study Trial by Caballero, Iraida, Aira, Lazaro E, Lavastida, Anabel, Popa, Xitlally, Rivero, Javier, González, Joaquín, Mesa, Mónica, González, Narjara, Coba, Kelly, Lorenzo-Luaces, Patricia, Wilkinson, Barbara, Santiesteban, Yuliannis, Santiesteban, Yanela, Troche, Mayelin, Suarez, Eduardo, Crombet, Tania, Sánchez, Belinda, Casacó, Angel, Macías, Amparo, Mazorra, Zaima

“…Metastatic castration-resistant prostate cancer (CRPC) remains incurable due to the lack of effective therapies. Activation of the human epidermal growth…”
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Considerations for reducing the euthanasia procedure in toxicological studies of biopharmaceuticals using non-human primates by CASACO, Angel, BEAUSOLEIL, Irene

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Expression and biological characterization of an anti-CD20 biosimilar candidate antibody: A case study by Dorvignit, Denise, Palacios, Julio L., Merino, Maylin, Hernández, Tays, Sosa, Katya, Casacó, Angel, López-Requena, Alejandro, Mateo de Acosta, Cristina

“…The CD20 molecule is a non-glycosylated protein expressed mainly on the surface of B lymphocytes. In some pathogenic B cells, it shows an increased expression,…”
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Effects of an epidermal growth factor receptor-based cancer vaccine on wound healing and inflammation processes in murine experimental models by Fuentes, Dasha, Chacón, Lewis, Casacó, Angel, Ledón, Nuris, Fernández, Nidia, Iglesias, Arianna, Hernández, Diana R, Sánchez, Belinda, Pérez, Rolando

“…Anti‐epidermal growth factor receptor (EGFR) therapies have been proven clinically effective for a variety of epithelial tumours. Vaccination of mice with the…”
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Effect of blockade of the EGF system on wound healing in patients vaccinated with CIMAvax® EGF by Fernández Lorente, Aymara, Acosta Brooks, Soraida, Neninger Vinageras, Elia, Barroso Alvarez, María del Carmen, Wilkinson Brito, Barbara, Troche Concepción, Mayelin, Martínez Pérez, Liana B, Viada González, Carmen E, Crespo Diaz, Tatiana, Casacó Parada, Angel Raymundo

“…The epidermal growth factor receptor (EGFR) signaling system is frequently unbalanced in human malignancies due to increased ligand production, receptor…”
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Evaluation of nimotuzumab Fab2 as an optical imaging agent in EGFR positive cancers by Bernhard, Wendy, Barreto, Kris, Toledo, Darien, El-Sayed, Ayman, Jett, Kimberly A., Casaco, Angel, Fonge, Humphrey, Geyer, C. Ronald

“…Molecular-targeted imaging probes can be used with a variety of imaging modalities to detect diseased tissues and guide their removal. EGFR is a useful…”
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Pre-clinical study of IRDye800CW-nimotuzumab formulation, stability, pharmacokinetics, and safety by Bernhard, Wendy, Barreto, Kris, El-Sayed, Ayman, Gonzalez, Carolina, Viswas, Raja Solomon, Toledo, Darien, Casaco, Angel, DeCoteau, John, Fonge, Humphrey, Geyer, Clarence Ronald

“…Epidermal growth factor receptor (EGFR) is a target for cancer therapy as it is overexpressed in a wide variety of cancers. Therapeutic antibodies that bind…”
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Pharmacokinetic comparison of two recombinant human granulocyte colony-stimulating factor after subcutaneous administration in rabbits by Ducongé, Jorge, Rodríguez-Vera, Leyanis, Valenzuela, Carmen, Álvarez, Daniel, Ramírez, Omar, de la Luz-Hernández, Kathya R., Rabeza-Legón, Estela Y., Casacó, Ángel, Fernández-Sánchez, Eduardo

“…A pharmacokinetic comparison between two formulations (LeukoCIM, CIMAB SA versus Neupogen ®, Hoffman-La Roche, licensed by Amgen) of recombinant human…”
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Immunohistochemical recognition of the epidermal growth factor receptor by the h-R3 antibody in the skin of experimental animals by Maceira, Maura, Rengifo, Enrique, Cedeño, Mercedes, Merino, Nelson, Casacó Parada, Angel

“…The h-R3 is a humanized monoclonal antibody (Mab) that binds to the external domain of the human epidermal growth factor receptor (EGF-R). It has being used…”
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Non-clinical immuno-toxicological evaluation of HER1 cancer vaccine in non-human primates: a 12-month study by Barro, Ana M. Bada, Rivero, Arianna Iglesias, Goñi, Avelina León, Navarro, Bárbara O. González, Angarica, Meilis Mesa, Ramírez, Belinda Sánchez, Bedoya, Darel Martínez, Triana, Consuelo González, Rodríguez, Axel Mancebo, Parada, Ángel Casacó

“…Highlights ► We assessed the immunotoxicity of HER1 vaccine in Macaca fascicularis . ► Treated monkeys received 9 doses of vaccination in a 12 months period. ►…”
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Systemic and skin toxicity in cercopithecus aethiops sabaeus monkeys treated during 26 weeks with a high intravenous dose of the anti-epidermal growth factor receptor monoclonal antibody nimotuzumab by Arteaga, Maria Elene, Nuris Ledon, Nuris, Casaco, Angel, Pardo, Balia, Garcia, Miriam, Boleda, Magela, Vina, Lisel, Orphee, Romy, Hernandez, Osvaldo, Gonzalez, Consuelo, Fuentes, Dasha, Rodriguez, Valia, Charro, Lidia, Baro, Farah, Macias, Amparo, Perez, Aylen, Morales, Yakelin, Subiros, Nelvys, Gonzalez, Barbara, Ramos, Mayra, Rodriquez, Leyanis, Ballester-Labrada, Alcides, Crombet, Tania

“…Nimotuzumab (h-R3) is a humanized anti-epidermal growth factor receptor monoclonal antibody (mAb) registered for treating head and neck tumours. The present…”
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Local and systemic toxicity of h-R3, an anti-epidermal growth factor receptor monoclonal antibody, labeled with 188osmiun after the intracerebral administration in rats by Gonzalez Navarro, Barbara, Casacó Parada, Angel, Alvarez, Pio, Leon, Avelina, Santana, Edilis, Bada, Ana, Figueredo, Rene, Iznaga-Escobar, Normando, Perez, Rolando

“…h-R3 is a humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb). This receptor is over-expressed in the majority of tumors of…”
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Phase I single-dose study of intracavitary-administered Nimotuzumab labeled with 188-Re in adult recurrent high-grade glioma by Casaco, Angel, López, Gerardo, García, Iván, Arsenio Rodríguez, José, Fernández, Ramsés, Figueredo, Javier, Torres, Leonel, Perera Pintado, Alejandro, Batista, Juan, Leyva, René, Peña, Yamilé, Amador, Zaida, González, Addys, Estupiñan, Barbara, Coca, Marcos, Hernández, Abel, Puig, Miguel, Iglesias, Marbelia, Hernández, Astrid, Ramos, Mayra, Rodriquez, Leyanis, Suarez, Niurelkis

“…Radioimmunotherapy (RIT) may improve the management of malignant gliomas. A Phase I clinical trial was performed to evaluate, for the first time, the toxicity…”
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Hematological, biochemical, respiratory, cardiovascular and electroneurophysiological parameters in African green monkeys (Cercopithecus aethiops sabaeus). Its use in non-clinical toxicological studies by Casacó, Angel, Beausoleil, Irene, Gonzalez, Bárbara, Luaces, Patricia, León, Avelina, Arteaga, María E., Prado, Pavel, Rodríguez, Valia, Pérez, Aylén, Guevara, Grisel, Bada, Ana M., Ledón, Nuris, Fuentes, Dasha, González, Consuelo, Hernandez, Osvaldo, Orphee, Romy, Blanco, Diuris, García-Osuma, Miriam, Ballester-Labrada, Alcides

“…Background  The purpose of this study is to better characterize the hematological, biochemical, respiratory, cardiovascular and electroneurophysiological…”
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Immuno-toxicological evaluation of her1 cancer vaccine in non-human primates: a 6-month subcutaneous study by Mancebo Rodríguez, Axel, Bergado Báez, Gretchen, Acosta Lago, Eric, León Goñi, Avelina, Blanco Gámez, Diuris, Fuentes Morales, Dasha, Hernández Fernández, Diana Rosa, Sánchez Ramírez, Belinda, Pérez Barreda, Aylen, Casacó Parada, Ángel

“…Purpose: A vaccine composition based on the extracellular domain of the human epidermal growth factor receptor 1 (HER1-ECD) and the combination of VSSP (very…”
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Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with (99m)Tc by Oliva, Juan P, Valdés, Zodilina, Casacó, Angel, Pimentel, Gilmara, González, Joaquín, Alvarez, Irene, Osorio, Martha, Velazco, Milagros, Figueroa, Mariela, Ortiz, Rosa, Escobar, Xiomara, Orozco, Maiby, Cruz, Julia, Franco, Sonia, Díaz, Mirtha, Roque, Lourdes, Carr, Adriana, Vázquez, Ana M, Mateos, Cristina, Rubio, María C, Pérez, Rolando, Fernández, Luis E

“…The relevance of certain gangliosides in tumour growth and metastatic dissemination has been well documented, reasons for considering these molecules as…”
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The chicken animal model for ovarian cancer and for pharmacological and toxicological evaluation of NGcGM3 ganglioside based treatments by Casaco, Angel, Gonzalez, Addys, Fernandez, Luis Enrique

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Clinical evidences of GM3 (NeuGc) ganglioside expression in human breast cancer using the 14F7 monoclonal antibody labelled with 99mTc by OLIVA, Juan P, VALDES, Zodilina, ESCOBAR, Xiomara, OROZCO, Maiby, CRUZ, Julia, FRANCO, Sonia, DIAZ, Mirtha, ROQUE, Lourdes, CARR, Adriana, VAZQUEZ, Ana M, MATEOS, Cristina, RUBIO, Maria C, CASACO, Angel, PEREZ, Rolando, FERNANDEZ, Luis E, PIMENTEL, Gilmara, GONZALEZ, Joaquin, ALVAREZ, Irene, OSORIO, Martha, VELAZCO, Milagros, FIGUEROA, Mariela, ORTIZ, Rosa

“…The relevance of certain gangliosides in tumour growth and metastatic dissemination has been well documented, reasons for considering these molecules as…”
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Preclinical studies predicting low clinical toxicity of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) nimotuzumab by Casacó, Angel, Ledón, Nuris, Iznaga-Escobar, Normando, Arteaga, Maria Elena, Crombet, Tania

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