Search Results - "Carvelli, Lucia"

Long-Lasting Epigenetic Changes in the Dopamine Transporter in Adult Animals Exposed to Amphetamine during Embryogenesis: Investigating Behavioral Effects by Ke, Tao, Ambigapathy, Ganesh, Ton, Thanh, Dhasarathy, Archana, Carvelli, Lucia

“…The dopamine transporter (DAT) is an integral member of the dopaminergic system and is responsible for the release and reuptake of dopamine from the synaptic…”
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Prolonged Amphetamine Treatments Cause Long-Term Decrease of Dopamine Uptake in Cultured Cells by Ferdous, Nafisa, Kudumala, Sirisha, Sossi, Serena, Carvelli, Lucia

“…Amphetamine (AMPH) is a systemic stimulant used to treat a variety of diseases including Attention Deficit Hyperactive Disorder, narcolepsy and obesity…”
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Amphetamine Exposure during Embryogenesis Alters Expression and Function of Tyrosine Hydroxylase and the Vesicular Monoamine Transporter in Adult C. elegans by Ke, Tao, Poquette, Katie E, Amro Gazze, Sophia L, Carvelli, Lucia

“…Amphetamines (Amph) are psychostimulants broadly used as physical and cognitive enhancers. However, the long-term effects of prenatal exposure to Amph have…”
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Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission by Carvelli, Lucia, Blakely, Randy D, DeFelice, Louis J

“…The Caenorhabditis elegans (C. elegans) dopamine (DA) transporter (DAT-1) regulates DA signaling through efficient DA reuptake following synaptic release. In…”
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Prolonged Amphetamine Exposures Increase the Endogenous Human Dopamine Receptors 2 at the Cellular Membrane in Cells Lacking the Dopamine Transporter by Nawaratne, Vindhya, McLaughlin, Sean P., Mayer, Felix P., Gichi, Zayna, Mastriano, Alyssa, Carvelli, Lucia

“…The dopamine 2 receptors (D2R) are G-protein coupled receptors expressed both in pre- and post-synaptic terminals that play an important role in mediating the…”
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Molecular mechanisms of amphetamine actions in Caenorhabditis elegans by Carvelli, Lucia, Matthies, Dawn S, Galli, Aurelio

“…Amphetamine (AMPH) poses a serious hazard to public health. Defining the molecular targets of AMPH is essential to developing treatments for psychostimulant…”
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Silencing of Syntaxin 1A in the Dopaminergic Neurons Decreases the Activity of the Dopamine Transporter and Prevents Amphetamine-Induced Behaviors in C. elegans by Lanzo, Ambra, Safratowich, Bryan D, Kudumala, Sirisha R, Gallotta, Ivan, Zampi, Giuseppina, Di Schiavi, Elia, Carvelli, Lucia

“…The dopamine transporter (DAT) is a cell membrane protein whose main function is to reuptake the dopamine (DA) released in the synaptic cleft back into the…”
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Dopamine Transporters Depolarize Neurons by a Channel Mechanism by Carvelli, Lucia, McDonald, Paul W., Blakely, Randy D., DeFelice, Louis J., Amara, Susan G.

“…Neurotransmitter transporters generate larger currents than expected if one assumes fixed stoichiometry models. It remains controversial, however, whether…”
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Amphetamine-Induced Loss of Human Dopamine Transporter Activity: An Internalization-Dependent and Cocaine-Sensitive Mechanism by Saunders, Christine, Ferrer, Jasmine V., Shi, Lei, Chen, Jiayun, Merrill, Gerald, Lamb, Maria E., L. M. Fredrik Leeb-Lundberg, Carvelli, Lucia, Javitch, Jonathan A., Galli, Aurelio

“…The dopamine transporter (DAT) is a target of amphetamine (AMPH) and cocaine. These psychostimulants attenuate DAT clearance efficiency, thereby increasing…”
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Transgenic SOD1 G93A mice develop reduced GLT‐1 in spinal cord without alterations in cerebrospinal fluid glutamate levels by Bendotti, Caterina, Tortarolo, Massimo, Suchak, Sachin K., Calvaresi, Novella, Carvelli, Lucia, Bastone, Antonio, Rizzi, Massimo, Rattray, Marcus, Mennini, Tiziana

“…Glutamate‐induced excitotoxicity is suggested to play a central role in the development of amyotrophic lateral sclerosis (ALS), although it is still unclear…”
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PI 3‐kinase regulation of dopamine uptake by Carvelli, Lucia, Morón, José A., Kahlig, Kristopher M., Ferrer, Jasmine V., Sen, Namita, Lechleiter, James D., Leeb‐Lundberg, L. M. Fredrik, Merrill, Gerald, Lafer, Eileen M., Ballou, Lisa M., Shippenberg, Toni S., Javitch, Jonathan A., Lin, Richard Z., Galli, Aurelio

“…The magnitude and duration of dopamine (DA) signaling is defined by the amount of vesicular release, DA receptor sensitivity, and the efficiency of DA…”
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Amphetamine exposure during embryogenesis changes expression and function of the dopamine transporter in Caenorhabditis elegans offspring by Ambigapathy, Ganesh, McCowan, Talus J., Carvelli, Lucia

“…The dopamine transporter (DAT) is a transmembrane protein that regulates dopamine (DA) neurotransmission by binding to and moving DA from the synaptic cleft…”
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Optimized Synthesis of AMPA Receptor Antagonist ZK 187638 and Neurobehavioral Activity in a Mouse Model of Neuronal Ceroid Lipofuscinosis by Elger, Bernd, Schneider, Matthias, Winter, Eric, Carvelli, Lucia, Bonomi, Marco, Fracasso, Claudia, Guiso, Giovanna, Colovic, Milena, Caccia, Silvio, Mennini, Tiziana

“…Previous structure–activity relationship studies in the search for a potent, noncompetitive α‐amino‐3‐(3‐hydroxy‐5‐methyl‐4‐isoxazolyl)propionic acid (AMPA)…”
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SLC6 transporters: Structure, function, regulation, disease association and therapeutics by Pramod, Akula Bala, Foster, James, Carvelli, Lucia, Henry, L. Keith

“…The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na+-dependent translocation of small amino…”
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Amphetamine activates/potentiates a ligand-gated ion channel by Carvelli, Lucia

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Amphetamine Exposure during Embryogenesis Alters Expression and Function of Tyrosine Hydroxylase and the Vesicular Monoamine Transporter in Adult IC. elegans/I by Ke, Tao, Poquette, Katie E, Amro Gazze, Sophia L, Carvelli, Lucia

“…Amphetamines (Amph) are psychostimulants broadly used as physical and cognitive enhancers. However, the long-term effects of prenatal exposure to Amph have…”
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Increased peripheral benzodiazepine binding sites and pentraxin 3 expression in the spinal cord during EAE: relation to inflammatory cytokines and modulation by dexamethasone and rolipram by Agnello, Davide, Carvelli, Lucia, Muzio, Valeria, Villa, Pia, Bottazzi, Barbara, Polentarutti, Nadia, Mennini, Tiziana, Mantovani, Alberto, Ghezzi, Pietro

“…We have studied the mRNA expression of pentraxin 3 (PTX3) and the binding of the peripheral-type benzodiazepine receptor (PBR) ligand, [ 3H]-PK11195, in the…”
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Swimming Induced Paralysis to Assess Dopamine Signaling in Caenorhabditis elegans by Kudumala, Sirisha, Sossi, Serena, Carvelli, Lucia

“…The swimming assay described in this protocol is a valid tool to identify proteins regulating the dopaminergic synapses. Similar to mammals, dopamine (DA)…”
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Chronic amphetamine exposure causes long‐term effects on dopamine uptake by Ferdous, Nafisa, McCowan, Talus J, Carvelli, Lucia

“…Abstract only The dopamine transporter (DAT) is a plasma membrane transporter that clears released dopamine from the synaptic cleft; therefore it is an…”
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Glial swip-10 controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis by Rodriguez, Peter, Kalia, Vrinda, Fenollar-Ferrer, Cristina, Gibson, Chelsea L, Gichi, Zayna, Rajoo, Andre, Matier, Carson D, Pezacki, Aidan T, Xiao, Tong, Carvelli, Lucia, Chang, Christopher J, Miller, Gary W, Khamoui, Andy V, Boerner, Jana, Blakely, Randy D

“…Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and…”
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