CD34 as a marker for evaluating angiogenesis in cervical cancer

CD34 is an antigen present in hematopoietic progenitor cells and endothelial cells. Anti-CD34 antibody is a highly sensitive marker for endothelial cell differentiation and has also been studied as a marker for vascular tumors. However, there are few studies relating it to cervical carcinoma. The ai...

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Bibliographic Details
Published in:	Pathology, research and practice Vol. 201; no. 4; pp. 313 - 318
Main Authors:	Vieira, Sabas C., Silva, Benedito B., Pinto, Glauce A., Vassallo, José, Moraes, Natália G., Santana, Jerúsia O.I., Santos, Lina G., Carvasan, Gislaine A.F., Zeferino, Luiz C.
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-01-2005
Subjects:	Adenocarcinoma - blood supply Adenocarcinoma - secondary Adult Aged Angiogenesis Antigens, CD34 - metabolism Biomarkers, Tumor - metabolism Carcinoma of the uterine cervix Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - secondary CD34 antigen Female Humans Immunohistochemistry Lymph Nodes - pathology Lymphatic Metastasis - pathology Microcirculation - pathology Middle Aged Neoplasm Staging Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pathological anatomy Uterine Cervical Neoplasms - blood supply Uterine Cervical Neoplasms - pathology Immunohistochemistry CD34 antigen Angiogenesis Carcinoma of the uterine cervix Pathological anatomy
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Summary:	CD34 is an antigen present in hematopoietic progenitor cells and endothelial cells. Anti-CD34 antibody is a highly sensitive marker for endothelial cell differentiation and has also been studied as a marker for vascular tumors. However, there are few studies relating it to cervical carcinoma. The aim of this study was to evaluate the association between angiogenesis and the pathoanatomical features of cervical carcinoma using anti-CD34 monoclonal antibody. Sixty-two patients with invasive carcinoma of the uterine cervix in stages Ib-IIa were included. A primary monoclonal antibody specific for CD34 (Anti-Human Hemapoietic Progenitor Cell, CD34 Class II, Clone QBEnd 10, Code M7165, DAKO Corporation) was used in a dilution of 1:25. Microvessel density varied from 4.8 to 20 and was higher in undifferentiated carcinomas ( p = 0.03 ; Mann–Whitney test). Higher microvessel density was associated with squamous cell carcinoma, odds ratio (OR) 8.8 (95% CI: 1.0–76.1), while the presence of lymphatic invasion yielded an OR of 2.6 (95% CI: 0.9–7.4). This study suggested that anti-CD34 antibody reactivity in cervical carcinoma is associated with pathoanatomical features indicative of poorer prognosis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0344-0338 1618-0631
DOI:	10.1016/j.prp.2005.01.010