Search Results - "Carvalho, Robson F"
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Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia
Published in Scientific reports (01-08-2017)“…Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms…”
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2
MicroRNA-499 expression distinctively correlates to target genes sox6 and rod1 profiles to resolve the skeletal muscle phenotype in Nile tilapia
Published in PloS one (20-03-2015)“…A class of small non-coding RNAs, the microRNAs (miRNAs), has been shown to be essential for the regulation of specific cell pathways, including skeletal…”
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Integrative microRNAome analysis of skeletal muscle of Colossoma macropomum (tambaqui), Piaractus mesopotamicus (pacu), and the hybrid tambacu, based on next-generation sequencing data
Published in BMC genomics (06-04-2021)“…Colossoma macropomum (tambaqui) and Piaractus mesopotamicus (pacu) are good fish species for aquaculture. The tambacu, individuals originating from the induced…”
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4
Aerobic exercise training prevents heart failure-induced skeletal muscle atrophy by anti-catabolic, but not anabolic actions
Published in PloS one (17-10-2014)“…Heart failure (HF) is associated with cachexia and consequent exercise intolerance. Given the beneficial effects of aerobic exercise training (ET) in HF, the…”
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Decreased miR-497-5p Suppresses IL-6 Induced Atrophy in Muscle Cells
Published in Cells (Basel, Switzerland) (14-12-2021)“…Interleukin-6 (IL-6) is a pro-inflammatory cytokine associated with skeletal muscle wasting in cancer cachexia. The control of gene expression by microRNAs…”
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Overexpression of PGC‐1α in aging muscle enhances a subset of young‐like molecular patterns
Published in Aging cell (01-04-2018)“…Summary PGC‐1α is a transcriptional co‐activator known as the master regulator of mitochondrial biogenesis. Its control of metabolism has been suggested to…”
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7
Origin and evolution of B chromosomes in the cichlid fish Astatotilapia latifasciata based on integrated genomic analyses
Published in Molecular biology and evolution (01-08-2014)“…Approximately 15% of eukaryotes contain supernumerary B chromosomes. When present, B chromosomes frequently represent as much as 5% of the genome. Despite…”
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Lyophilized açaí pulp (Euterpe oleracea Mart) attenuates colitis-associated colon carcinogenesis while its main anthocyanin has the potential to affect the motility of colon cancer cells
Published in Food and chemical toxicology (01-11-2018)“…This study evaluated the possible protective effects of lyophilized açaí pulp (AP) in a colitis-associated carcinogenesis (CAC) rat model and the modifying…”
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Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways
Published in Cancers (01-08-2020)“…Background: Micro(mi)RNAs, potent gene expression regulators associated with tumorigenesis, are stable, abundant circulating molecules, and detectable in…”
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Exercise during transition from compensated left ventricular hypertrophy to heart failure in aortic stenosis rats
Published in Journal of cellular and molecular medicine (01-02-2019)“…We evaluated the influence of aerobic exercise on cardiac remodelling during the transition from compensated left ventricular (LV) hypertrophy to clinical…”
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11
MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma
Published in PloS one (31-05-2019)“…Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated…”
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12
Identifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis
Published in Cancers (01-09-2023)“…Lung tumors frequently metastasize to the brain. Brain metastasis (BM) is common in advanced cases, and a major cause of patient morbidity and mortality. The…”
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13
Regulation of cardiac microRNAs induced by aerobic exercise training during heart failure
Published in American journal of physiology. Heart and circulatory physiology (15-11-2015)“…Exercise training (ET) has beneficial effects on the myocardium in heart failure (HF) patients and in animal models of induced cardiac hypertrophy and failure…”
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Propolis modulates miRNAs involved in TLR-4 pathway, NF-[kappa]B activation, cytokine production and in the bactericidal activity of human dendritic cells
Published in Journal of pharmacy and pharmacology (01-12-2016)“…Objectives Dendritic cells (DCs) are antigen-presenting cells, essential for recognition and presentation of pathogens to T cells. Propolis, a resinous…”
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15
Enhancement of colon carcinogenesis by the combination of indole-3 carbinol and synbiotics in hemin-fed rats
Published in Food and chemical toxicology (01-02-2018)“…The risk of developing colorectal cancer (CRC) could be associated with red and processed meat intake. Experimental data supports that hemin iron, found…”
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Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma
Published in Oncotarget (17-05-2016)“…Herein, we aimed at identifying global transcriptome microRNA (miRNA) changes and miRNA target genes in lung adenocarcinoma. Samples were selected as training…”
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Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/PGC-1α Complex in Aged Rats
Published in The journals of gerontology. Series A, Biological sciences and medical sciences (01-05-2016)“…Physical training has been shown to be important to the control of muscle mass during aging, through the activation of several pathways including, IGF1-AKT and…”
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Propolis modulates miRNAs involved in TLR-4 pathway, NF-κB activation, cytokine production and in the bactericidal activity of human dendritic cells
Published in Journal of pharmacy and pharmacology (01-12-2016)“…Objectives Dendritic cells (DCs) are antigen‐presenting cells, essential for recognition and presentation of pathogens to T cells. Propolis, a resinous…”
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Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach
Published in npj aging (24-08-2023)“…Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions…”
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Deregulated microRNAs Are Associated with Patient Survival and Predicted to Target Genes That Modulate Lung Cancer Signaling Pathways
Published in Cancers (22-09-2020)“…(1) Background: Although the advances in diagnostic and treatment strategies, lung cancer remains the leading cause of cancer-related deaths, worldwide, with…”
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