Search Results - "Carvalho, Pedro Luiz de"

Discovery of a glycerol 3-phosphate phosphatase reveals glycerophospholipid polar head recycling in Mycobacterium tuberculosis by Larrouy-Maumus, Gérald, Biswas, Tapan, Hunt, Debbie M., Kelly, Geoff, Tsodikov, Oleg V., de Carvalho, Luiz Pedro Sório

“…Functional assignment of enzymes encoded by the Mycobacterium tuberculosis genome is largely incomplete despite recent advances in genomics and bioinformatics…”
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d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition by de Chiara, Cesira, Homšak, Miha, Prosser, Gareth A., Douglas, Holly L., Garza-Garcia, Acely, Kelly, Geoff, Purkiss, Andrew G., Tate, Edward W., de Carvalho, Luiz Pedro S.

“…The broad-spectrum antibiotic d -cycloserine (DCS) is a key component of regimens used to treat multi- and extensively drug-resistant tuberculosis. DCS, a…”
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Flexible nitrogen utilisation by the metabolic generalist pathogen Mycobacterium tuberculosis by Agapova, Aleksandra, Serafini, Agnese, Petridis, Michael, Hunt, Debbie M, Garza-Garcia, Acely, Sohaskey, Charles D, de Carvalho, Luiz Pedro Sório

“…Bacterial metabolism is fundamental to survival and pathogenesis. We explore how utilises amino acids as nitrogen sources, using a combination of bacterial…”
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Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine by Batson, Sarah, de Chiara, Cesira, Majce, Vita, Lloyd, Adrian J., Gobec, Stanislav, Rea, Dean, Fülöp, Vilmos, Thoroughgood, Christopher W., Simmons, Katie J., Dowson, Christopher G., Fishwick, Colin W. G., de Carvalho, Luiz Pedro S., Roper, David I.

“…D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine…”
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Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors by Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Smith, Darren, Evans, Jack W.D., Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Levy, Colin W., Munro, Andrew W., Simons, Claire

“…The emergence of untreatable drug‐resistant strains of Mycobacterium tuberculosis is a major public health problem worldwide, and the identification of new…”
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Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes by Evangelopoulos, Dimitrios, Prosser, Gareth A., Rodgers, Angela, Dagg, Belinda M., Khatri, Bhagwati, Ho, Mei Mei, Gutierrez, Maximiliano G., Cortes, Teresa, de Carvalho, Luiz Pedro S.

“…Drug resistant infections represent one of the most challenging medical problems of our time. D -cycloserine is an antibiotic used for six decades without…”
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Uncoupling conformational states from activity in an allosteric enzyme by Pisco, João P., de Chiara, Cesira, Pacholarz, Kamila J., Garza-Garcia, Acely, Ogrodowicz, Roksana W., Walker, Philip A., Barran, Perdita E., Smerdon, Stephen J., de Carvalho, Luiz Pedro S.

“…ATP-phosphoribosyltransferase (ATP-PRT) is a hexameric enzyme in conformational equilibrium between an open and seemingly active state and a closed and…”
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Glutamate Racemase Is the Primary Target of β-Chloro-d-Alanine in Mycobacterium tuberculosis by Prosser, Gareth A, Rodenburg, Anne, Khoury, Hania, de Chiara, Cesira, Howell, Steve, Snijders, Ambrosius P, de Carvalho, Luiz Pedro S

“…The increasing global prevalence of drug resistance among many leading human pathogens necessitates both the development of antibiotics with novel mechanisms…”
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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase by Goldstone, David C., Ennis-Adeniran, Valerie, Hedden, Joseph J., Groom, Harriet C. T., Rice, Gillian I., Christodoulou, Evangelos, Walker, Philip A., Kelly, Geoff, Haire, Lesley F., Yap, Melvyn W., de Carvalho, Luiz Pedro S., Stoye, Jonathan P., Crow, Yanick J., Taylor, Ian A., Webb, Michelle

“…Antiretroviral role for SAMHD1 protein Mutations in SAMHD1 protein are associated with the human autoimmune disease Aicardi–Goutières syndrome, and SAMHD1 was…”
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Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism by Serafini, Agnese, Tan, Lendl, Horswell, Stuart, Howell, Steven, Greenwood, Daniel J., Hunt, Deborah M., Phan, Minh‐Duy, Schembri, Mark, Monteleone, Mercedes, Montague, Christine R., Britton, Warwick, Garza‐Garcia, Acely, Snijders, Ambrosius P., VanderVen, Brian, Gutierrez, Maximiliano G., West, Nicholas P., Carvalho, Luiz Pedro S.

“…Summary Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative…”
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Metabolomic strategies for the identification of new enzyme functions and metabolic pathways by Prosser, Gareth A, Larrouy-Maumus, Gerald, de Carvalho, Luiz Pedro S

“…Recent technological advances in accurate mass spectrometry and data analysis have revolutionized metabolomics experimentation. Activity‐based and global…”
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Interactive effects of digestible protein levels on thermal and physical stress responses in Nile tilapia by Freitas, Jakeline Marcela Azambuja de, Peres, Helena, Carvalho, Pedro Luiz Pucci Figueiredo de, Furuya, Wilson Massamitu, Sartori, Maria Márcia Pereira, Pezzato, Luiz Edivaldo, Barros, Margarida Maria

“…ABSTRACT The effects of dietary digestible protein (DP) levels (22, 26, 29, 32, and 34%) and different stressors (cold-induced stress, CIS; heat/dissolved…”
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Kinetic mechanism and inhibition of Mycobacterium tuberculosis d‐alanine:d‐alanine ligase by the antibiotic d‐cycloserine by Prosser, Gareth A., Carvalho, Luiz Pedro S.

“…d‐cycloserine (DCS) is an antibiotic that is currently used in second‐line treatment of tuberculosis. DCS is a structural analogue of d‐alanine, and targets…”
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Streptococcal dTDP‐L‐rhamnose biosynthesis enzymes: functional characterization and lead compound identification by van der Beek, Samantha L., Zorzoli, Azul, Çanak, Ebru, Chapman, Robert N., Lucas, Kieron, Meyer, Benjamin H., Evangelopoulos, Dimitrios, de Carvalho, Luiz Pedro S., Boons, Geert‐Jan, Dorfmueller, Helge C., van Sorge, Nina M.

“…Summary Biosynthesis of the nucleotide sugar precursor dTDP‐L‐rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including…”
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Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection by Gouzy, Alexandre, Larrouy-Maumus, Gérald, Bottai, Daria, Levillain, Florence, Dumas, Alexia, Wallach, Joshua B, Caire-Brandli, Irène, de Chastellier, Chantal, Wu, Ting-Di, Poincloux, Renaud, Brosch, Roland, Guerquin-Kern, Jean-Luc, Schnappinger, Dirk, Sório de Carvalho, Luiz Pedro, Poquet, Yannick, Neyrolles, Olivier

“…Mycobacterium tuberculosis is an intracellular pathogen. Within macrophages, M. tuberculosis thrives in a specialized membrane-bound vacuole, the phagosome,…”
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Crucial role for central carbon metabolism in the bacterial L-form switch and killing by β-lactam antibiotics by Kawai, Yoshikazu, Mercier, Romain, Mickiewicz, Katarzyna, Serafini, Agnese, Sório de Carvalho, Luiz Pedro, Errington, Jeff

“…The peptidoglycan cell wall is an essential structure for the growth of most bacteria. However, many are capable of switching into a wall-deficient L-form…”
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Biosynthesis and Translocation of Unsulfated Acyltrehaloses in Mycobacterium tuberculosis by Belardinelli, Juan Manuel, Larrouy-Maumus, Gérald, Jones, Victoria, Sorio de Carvalho, Luiz Pedro, McNeil, Michael R., Jackson, Mary

“…A number of species-specific polymethyl-branched fatty acid-containing trehalose esters populate the outer membrane of Mycobacterium tuberculosis. Among them,…”
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A novel regulatory factor affecting the transcription of methionine biosynthesis genes in Escherichia coli experiencing sustained nitrogen starvation by Switzer, Amy, Evangelopoulos, Dimitrios, Figueira, Rita, de Carvalho, Luiz Pedro S, Brown, Daniel R, Wigneshweraraj, Sivaramesh

“…The initial adaptive transcriptional response to nitrogen (N) starvation in Escherichia coli involves large-scale alterations to the transcriptome mediated by…”
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Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate by Gouzy, Alexandre, Larrouy-Maumus, Gérald, Wu, Ting-Di, Peixoto, Antonio, Levillain, Florence, Lugo-Villarino, Geanncarlo, Guerquin-Kern, Jean-Luc, de Carvalho, Luiz Pedro Sório, Poquet, Yannick, Neyrolles, Olivier

“…Aspartate is a primary nitrogen source for Mycobacterium tuberculosis during infection, being required for virulence after entering cells via the amino acid…”
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Divergent downstream biosynthetic pathways are supported by L-cysteine synthases of Mycobacterium tuberculosis by Khan, Mehak Zahoor, Hunt, Debbie M, Singha, Biplab, Kapoor, Yogita, Singh, Nitesh Kumar, Prasad, D V Sai, Dharmarajan, Sriram, Sowpati, Divya Tej, de Carvalho, Luiz Pedro S, Nandicoori, Vinay Kumar

“…'s ( ) autarkic lifestyle within the host involves rewiring its transcriptional networks to combat host-induced stresses. With the help of RNA sequencing…”
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