Modeling of Interstitial Ultrasound Ablation for Continuous Applicator Rotation With MR Validation

The primary objective of cancer intervention is the selective removal of malignant cells while conserving surrounding healthy tissues. However, the accessibility, size and shape of the cancer can make achieving appropriate margins a challenge. One minimally invasive treatment option for these clinic...

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Bibliographic Details
Published in:	IEEE transactions on biomedical engineering Vol. 68; no. 6; pp. 1838 - 1846
Main Authors:	Gandomi, Katie Y., Carvalho, Paulo A. W. G., Tarasek, Matthew, Fiveland, Eric W., Bhushan, Chitresh, Williams, Emery, Neubauer, Paul, Zhao, Zhanyue, Pilitsis, Julie, Yeo, Desmond, Nycz, Christopher J., Burdette, Everette, Fischer, Gregory S.
Format:	Journal Article
Language:	English
Published:	United States IEEE 01-06-2021 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Ablation Acoustics Animals Applicators Cancer Conformal tumor ablation Correlation coefficient Correlation coefficients Deposition Finite element method finite element modeling Gelatin Heating systems interstitial therapeutic ultrasound Magnetic Resonance Imaging magnetic resonance thermal imaging Mathematical model Mathematical models Motion effects Phantoms, Imaging Probes robot assisted surgeries Robot control Rotation Spatial discrimination Spatial resolution Swine Thermal imaging Thermal simulation Trajectory analysis Transducers Ultrasonic imaging Ultrasonic Therapy Ultrasonography Ultrasound
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Summary:	The primary objective of cancer intervention is the selective removal of malignant cells while conserving surrounding healthy tissues. However, the accessibility, size and shape of the cancer can make achieving appropriate margins a challenge. One minimally invasive treatment option for these clinical cases is interstitial needle based therapeutic ultrasound (NBTU). In this work, we develop a finite element model (FEM) capable of simulating continuous rotation of a directional NBTU applicator. The developed model was used to simulate the thermal deposition for different rotation trajectories. The actual thermal deposition patterns for the simulated trajectories were then evaluated using magnetic resonance thermal imaging (MRTI) in a porcine skin gelatin phantom. An MRI-compatible robot was used to control the rotation motion profile of the physical NBTU applicator to match the simulated trajectory. The model showed agreement when compared to experimental measurements with Pearson correlation coefficients greater than 0.839 when comparing temperature fields within an area of 12.6 mm radius from the ultrasound applicator. The average temperature error along a 6.3 mm radius profile from the applicator was <inline-formula><tex-math notation="LaTeX">1.27\;^\circ\mathrm{C}</tex-math></inline-formula>. The model was able to compute 1 s of thermal deposition by the applicator in 0.2 s on average with a 0.1 mm spatial resolution and 0.5 s time steps. The developed simulation demonstrates performance suitable for real-time control which may enable robotically-actuated closed-loop conformal tumor ablation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0018-9294 1558-2531
DOI:	10.1109/TBME.2020.3023849