L-carnitine supplementation in the recovery of plasma L-carnitine in patients with heart failure submitted to coronary artery bypass grafting

Coronary artery bypass grafting reduces plasma L-carnitine and may impair the production of myocardial energy. L-carnitine supplementation may elevate plasma L-carnitine and increase cardiac mechanical efficiency. The objective of this study was to verify the recovery of preoperative plasma LC in pa...

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Published in:	Anais da Academia Brasileira de Ciências Vol. 90; no. 3; pp. 3099 - 3104
Main Authors:	Cruz, Wanise M Souza, Guimarães, Sheila M S, Maciel, Gabrielle C, Huguenin, Ana Beatriz A, Carvalho, Monicque E M DE, Costa, Bárbara O, Silva, Geisiane A DA, Colafranceschi, Alexandre S, Scalco, Fernanda B, Ribeiro, Marcia
Format:	Journal Article
Language:	English
Published:	Brazil Academia Brasileira de Ciências 01-07-2018
Subjects:	Carnitine - administration & dosage Carnitine - blood Coronary Artery Bypass - adverse effects Dietary Supplements Double-Blind Method Female Heart Failure - blood Heart Failure - etiology Heart Failure - surgery Humans ischemic heart failure Male Middle Aged MULTIDISCIPLINARY SCIENCES myocardial revascularization surgery oral L-carnitine supplementation Placebos plasma L-carnitine Treatment Outcome oral L-carnitine supplementation myocardial revascularization surgery ischemic heart failure plasma L-carnitine
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Summary:	Coronary artery bypass grafting reduces plasma L-carnitine and may impair the production of myocardial energy. L-carnitine supplementation may elevate plasma L-carnitine and increase cardiac mechanical efficiency. The objective of this study was to verify the recovery of preoperative plasma LC in patients with heart failure undergoing coronary artery bypass grafting supplemented with a daily oral dose of 50 mg / kg. Volunteers with ischemic heart failure who underwent surgery were randomized into a supplemented group (A-received 50 mg / kg L-carnitine) or placebo group (B) for 60 days. Supplementation was started on the third postoperative day. The spectrophotometric enzymatic method was used to quantify plasma L-carnitine. In the preoperative period, both groups had plasma L-carnitine adequate to the reference range (18.9-71.1 μM). On the second postoperative day, there was a reduction in plasma L-carnitine in groups A (17.4%) and B (14.4%). In the comparison between the groups, plasma L-carnitine was higher in group A than B in 10º (p = 0.024), 30º (p = 0.001), and 60º postoperative day (p = 0.008). Supplementation of L-carnitine at a daily oral dose of 50 mg / kg in patients with heart failure undergoing coronary artery bypass grafting may recover preoperative plasma L-carnitine within 10 days.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0001-3765 1678-2690 1678-2690
DOI:	10.1590/0001-3765201820170352