Search Results - "Carvalho, Jonatan C. S."
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The turning point of COVID‐19 severity is associated with a unique circulating neutrophil gene signature
Published in Immunology (01-07-2023)“…COVID‐19 has a broad spectrum of clinical manifestations associated with the host immune response heterogeneity. Despite the advances in COVID‐19 research, it…”
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The Severity of COVID-19 Affects the Plasma Soluble Levels of the Immune Checkpoint HLA-G Molecule
Published in International journal of molecular sciences (27-08-2022)“…The non-classical histocompatibility antigen G (HLA-G) is an immune checkpoint molecule that has been implicated in viral disorders. We evaluated the plasma…”
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Acetylcholine, Fatty Acids, and Lipid Mediators Are Linked to COVID-19 Severity
Published in The Journal of immunology (1950) (15-07-2022)“…Lipid and cholinergic mediators are inflammatory regulators, but their role in the immunopathology of COVID-19 is still unclear. Here, we used human blood and…”
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Divergent androgenic modulation of SARS-CoV-2 infection cooperates with dysregulated immune response to dictate worse COVID-19 outcomes in men
Published in Brain, behavior, and immunity (01-11-2023)“…•Lowering testosterone is a hallmark of the worst COVID-19 prognosis in men.•Reduced testosterone in men with COVID-19 is partially dependent on age and…”
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Plasma Sphingomyelin Disturbances: Unveiling Its Dual Role as a Crucial Immunopathological Factor and a Severity Prognostic Biomarker in COVID-19
Published in Cells (Basel, Switzerland) (26-07-2023)“…SARS-CoV-2 infection triggers distinct patterns of disease development characterized by significant alterations in host regulatory responses. Severe cases…”
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sTREM-1 Predicts Disease Severity and Mortality in COVID-19 Patients: Involvement of Peripheral Blood Leukocytes and MMP-8 Activity
Published in Viruses (15-12-2021)“…Uncontrolled inflammatory responses play a critical role in coronavirus disease (COVID-19). In this context, because the triggering-receptor expressed on…”
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Matrix Metalloproteinases on Severe COVID-19 Lung Disease Pathogenesis: Cooperative Actions of MMP-8/MMP-2 Axis on Immune Response through HLA-G Shedding and Oxidative Stress
Published in Biomolecules (Basel, Switzerland) (19-04-2022)“…Patients with COVID-19 predominantly have a respiratory tract infection and acute lung failure is the most severe complication. While the molecular basis of…”
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The IgG glycome of SARS-CoV-2 infected individuals reflects disease course and severity
Published in Frontiers in immunology (18-10-2022)“…Immunoglobulin G (IgG) antibodies play an important role in the immune response against viruses such as SARS-CoV-2. As the effector functions of IgG are…”
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The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19
Published in Viruses (01-02-2023)“…COVID-19 is associated with a dysregulated immune response. Currently, several medicines are licensed for the treatment of this disease. Due to their…”
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