Search Results - "Carvalho, Ana M."

Evaluation of the Potential of Collagen from Codfish Skin as a Biomaterial for Biomedical Applications by Carvalho, Ana M, Marques, Alexandra P, Silva, Tiago H, Reis, Rui L

“…Collagen is one of the most widely used biomaterials, not only due its biocompatibility, biodegradability and weak antigenic potential, but also due to its…”
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Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy by Félix, Maria M, Tavares, Mariana V, Santos, Inês P, Batista de Carvalho, Ana L M, Batista de Carvalho, Luís A E, Marques, Maria Paula M

“…Cervical cancer was considered the fourth most common cancer worldwide in 2020. In order to reduce mortality, an early diagnosis of the tumor is required…”
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A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line by Silva, Jéssica D, Marques, Joana, Santos, Inês P, Batista de Carvalho, Ana L M, Martins, Clara B, Laginha, Raquel C, Batista de Carvalho, Luís A E, Marques, Maria Paula M

“…A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt Put (NH ) ]Cl ) was synthesized and assessed as to its potential anticancer…”
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Impact of Conventional and Potential New Metal-Based Drugs on Lipid Metabolism in Osteosarcoma MG-63 Cells by Bispo, Daniela S C, Correia, Marlene, Carneiro, Tatiana J, Martins, Ana S, Reis, Aliana A N, Carvalho, Ana L M Batista de, Marques, Maria P M, Gil, Ana M

“…This work investigated the mechanisms of action of conventional drugs, cisplatin and oxaliplatin, and the potentially less deleterious drug Pd Spermine (Spm)…”
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Effect of Pd2Spermine on Mice Brain-Liver Axis Metabolism Assessed by NMR Metabolomics by Carneiro, Tatiana J., Vojtek, Martin, Gonçalves-Monteiro, Salomé, Batista de Carvalho, Ana L. M., Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…Cisplatin (cDDP)-based chemotherapy is often limited by severe deleterious effects (nephrotoxicity, hepatotoxicity and neurotoxicity). The polynuclear…”
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A New Look into the Mode of Action of Metal-Based Anticancer Drugs by Marques, M Paula M, Batista de Carvalho, Ana L M, Mamede, Adriana P, Dopplapudi, Asha, Rudić, Svemir, Tyagi, Madhusudan, Garcia Sakai, Victoria, Batista de Carvalho, Luís A E

“…The mode of action of Pt- and Pd-based anticancer agents (cisplatin and Pd Spm) was studied by characterising their impact on DNA. Changes in conformation and…”
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Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies by Laginha, Raquel C., Martins, Clara B., Brandão, Ana L. C., Marques, Joana, Marques, M. Paula M., Batista de Carvalho, Luís A. E., Santos, Inês P., Batista de Carvalho, Ana L. M.

“…Regarding the development of new antineoplastic agents, with a view to assess the selective antitumoral potential which aims at causing irreversible damage to…”
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Cardiovascular risk assessment using SCORE2 in a population with hypertension – The reality at a primary health care unit by Pereira Santos, Sara, Guedes, Sara, Pesqueira, Ricardo, Stuart, João, Carvalho, Ana M., Correia, Patrícia, Lourenço Ribeiro, Isabel, Teixeira, Ângela M.

“…Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal, thus it is important to identify individuals at risk. Patients with…”
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Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis by Brás, Joana L.A, Cartmell, Alan, Carvalho, Ana Luísa M, Verzé, Genny, Bayer, Edward A, Vazana, Yael, Correia, Márcia A.S, Prates, José A.M, Ratnaparkhe, Supriya, Boraston, Alisdair B, Romão, Maria J, Fontes, Carlos M.G.A, Gilbert, Harry J

“…Clostridium thermocellum is a well-characterized cellulose-degrading microorganism. The genome sequence of C. thermocellum encodes a number of proteins that…”
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Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin by Vojtek, Martin, Martins, Clara B, Ramos, Raquel, Duarte, Sara Gomes, Ferreira, Isabel M P L V O, Batista de Carvalho, Ana L M, Marques, M Paula M, Diniz, Carmen

“…Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though…”
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Chemotherapeutic Targets in Osteosarcoma: Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering by Marques, Maria Paula M, Batista de Carvalho, Ana L. M, Mamede, Adriana P, Santos, Inês P, García Sakai, Victoria, Dopplapudi, Asha, Cinque, Gianfelice, Wolna, Magda, Gardner, Peter, Batista de Carvalho, Luís A. E

“…This study aimed at the development of improved drugs against human osteosarcoma, which is the most common primary bone tumor in children and teenagers with a…”
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Metabolic Impact of Anticancer Drugs Pd2Spermine and Cisplatin on the Brain of Healthy Mice by Carneiro, Tatiana J., Vojtek, Martin, Gonçalves-Monteiro, Salomé, Neves, João R., Carvalho, Ana L. M. Batista de, Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…The new palladium agent Pd2Spermine (Spm) has been reported to exhibit promising cytotoxic properties, while potentially circumventing the known disadvantages…”
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Blood Perfusion of Random Skin Flaps in Humans—In Vivo Assessment by Laser Speckle Contrast Imaging by Carvalho Brinca, Ana M., de Castro Pinho, André, Costa Vieira, Ricardo J. D.

“…The viability of random skin flaps (RSFs) depends on an adequate perfusion pressure to avoid necrosis. Laser speckle contrast imaging is a new method to…”
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Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent by Batista de Carvalho, Ana L M, Medeiros, Paula S C, Costa, Francisco M, Ribeiro, Vanessa P, Sousa, Joana B, Diniz, Carmen, Marques, Maria P M

“…The present work is aimed at evaluating the antitumour properties of a Pd(II) dinuclear complex with the biogenic polyamine spermine, by investigating: i) the…”
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Concept Development—From Academia to Industry: A Journey Motivated by the Design of Portable Thermal Slippers by Duarte, Belmiro P. M., Carvalho, Ana M. F., Lima, Daniela S. B., Costa, Diana I. S., Nunes, Inês R., Batista, João P. S. C., Gomes, Paulo J. S., Bernardo, Fernando P.

“…Concept design is an early and crucial phase in product development where the general concept of a product is created. In this stage, various aspects of the…”
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Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs by Martins, Ana S, Batista de Carvalho, Ana L M, Marques, Maria P M, Gil, Ana M

“…This paper reports the first metabolomics study of the impact of new chelates Pt Spm and Pd Spm (Spm = Spermine) on human osteosarcoma cellular metabolism,…”
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Neonatal Candidemia Caused by Candida haemulonii: Case Report and Review of Literature by Silva, Carolina M., Carvalho-Parahym, Ana M. R., Macêdo, Danielle P. C., Lima-Neto, Reginaldo G., Francisco, Elaine C., Melo, Analy S. A., da Conceição M. Silva, Maria, Jucá, Moacir B., Mello, Luciana R. B., Amorim, Rosemary M. J., Neves, Rejane P.

“…Candidemia is a frequent condition in Neonatal Intensive Care Units (NICU) and usually complicates the newborns clinical course. Several factors are…”
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Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer by Carneiro, Tatiana J., Batista de Carvalho, Ana L. M., Vojtek, Martin, Laginha, Raquel C., Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…Cisplatin (cDDP) resistance is a matter of concern in triple-negative breast cancer therapeutics. We measured the metabolic response of cDDP-sensitive (S) and…”
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Impact of the Pd2Spm (Spermine) Complex on the Metabolism of Triple-Negative Breast Cancer Tumors of a Xenograft Mouse Model by Carneiro, Tatiana J., Araújo, Rita, Vojtek, Martin, Gonçalves-Monteiro, Salomé, de Carvalho, Ana L. M. Batista, Marques, Maria Paula M., Diniz, Carmen, Gil, Ana M.

“…The interest in palladium(II) compounds as potential new anticancer drugs has increased in recent years, due to their high toxicity and acquired resistance to…”
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Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity by Pires, Cristiana L., Praça, Catarina, Martins, Patrícia A. T., Batista de Carvalho, Ana L. M., Ferreira, Lino, Marques, Maria Paula M., Moreno, Maria João

“…Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a…”
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