Regulation of Redox Profile and Genomic Instability by Physical Exercise Contributes to Neuroprotection in Mice with Experimental Glioblastoma

Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive. To further understand this, an investigation was conducted on physical training's effects on behavior, redox balance, and genomic st...

Full description

Saved in:

Bibliographic Details
Published in:	Antioxidants Vol. 12; no. 7; p. 1343
Main Authors:	Marqueze, Luis F B, Costa, Amanda K, Pedroso, Giulia S, Vasconcellos, Franciane F, Pilger, Bruna I, Kindermann, Schellen, Andrade, Vanessa M, Alves, Ana C B, Nery, Tatyana, Silva, Jr, Aderbal A, Carvalhal, Stephanie R S, Zazula, Matheus F, Naliwaiko, Katya, Fernandes, Luiz C, Radak, Zsolt, Pinho, Ricardo A
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26-06-2023 MDPI
Subjects:	Analysis Animal control brain tumor Brain tumors Ethylenediaminetetraacetic acid Euthanasia Exercise Feeds Fitness equipment Genomic instability genomic stability Glioblastoma Glioblastoma multiforme Latency Mice Neuroprotection Open-field behavior oxidative stress physical exercise Physical training Proteins Reactive oxygen species Surgery Tumors Brazil United States > US brain tumor glioblastoma physical exercise genomic stability oxidative stress
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Glioblastoma (GBM) is an aggressive, common brain cancer known to disrupt redox biology, affecting behavior and DNA integrity. Past research remains inconclusive. To further understand this, an investigation was conducted on physical training's effects on behavior, redox balance, and genomic stability in GBMA models. Forty-seven male C57BL/6J mice, 60 days old, were divided into GBM and sham groups ( = 15, = 10, respectively), which were further subdivided into trained (Str, Gtr; = 10, = 12) and untrained (Sut, Gut; = 10, = 15) subsets. The trained mice performed moderate aerobic exercises on a treadmill five to six times a week for a month while untrained mice remained in their enclosures. Behavior was evaluated using open-field and rotarod tests. Post training, the mice were euthanized and brain, liver, bone marrow, and blood samples were analyzed for redox and genomic instability markers. The results indicated increased latency values in the trained GBM (Gtr) group, suggesting a beneficial impact of exercise. Elevated reactive oxygen species in the parietal tissue of untrained GBM mice (Gut) were reduced post training. Moreover, Gtr mice exhibited lower tail intensity, indicating less genomic instability. Thus, exercise could serve as a promising supplemental GBM treatment, modulating redox parameters and reducing genomic instability.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2076-3921 2076-3921
DOI:	10.3390/antiox12071343