Search Results - "Caruncho, H"

Intravenous Reelin rescues despair-like behavior, Reelin cells in the dentate sub-granular zone, and spleen atrophy in the cyclic corticosterone model of recurring depressive episodes by Reive, B S, Johnston, J, Sánchez-Lafuente, C L, Scheil, Kaylene, Kurz, K, Kalynchuk, L E, Caruncho, H J

“…Novel antidepressants are predominantly evaluated preclinically in rodent models of chronic stress in which animals experience a single prolonged exposure to…”
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Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions by Botterill, J.J., Nogovitsyn, N., Caruncho, H.J., Kalynchuk, L.E.

“…The vulnerability and plasticity of hippocampal GABAergic interneurons is a topic of broad interest and debate in the field of epilepsy. In this experiment, we…”
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DNA-Methyltransferase 1 mRNA Is Selectively Overexpressed in Telencephalic GABAergic Interneurons of Schizophrenia Brains by Veldic, M., Caruncho, H. J., Liu, W. S., Davis, J., Satta, R., Grayson, D. R., Guidotti, A., Costa, E.

“…A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was detected in γ-aminobutyric acid (GABA)ergic cortical interneurons of…”
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Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress by Lussier, A.L, Romay-Tallón, R, Caruncho, H.J, Kalynchuk, L.E

“…Highlights ► We studied the effect of corticosterone and restraint stress on GABA and glutamate. ► CORT decreased GAD65 and the α2 subunit and increased VGLUT2…”
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An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes by Zhubi, A, Veldic, M, Puri, N.V, Kadriu, B, Caruncho, H, Loza, I, Sershen, H, Lajtha, A, Smith, R.C, Guidotti, A, Davis, J.M, Costa, E

“…Abstract Several lines of schizophrenia (SZ) research suggest that a functional downregulation of the prefrontal cortex GABAergic neuronal system is mediated…”
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Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory by Botterill, J.J, Brymer, K.J, Caruncho, H.J, Kalynchuk, L.E

“…Abstract Seizures dramatically increase the number of adult generated neurons in the hippocampus. However, it is not known whether this effect depends on…”
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Limbic but not non-limbic kindling impairs conditioned fear and promotes plasticity of NPY and its Y2 receptor by Botterill, J. J., Guskjolen, A. J., Marks, W. N., Caruncho, H. J., Kalynchuk, L. E.

“…Epileptic seizures negatively affect cognition. However, the mechanisms that contribute to cognitive impairments after seizures are largely unknown. Here, we…”
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Reelin is Preferentially Expressed in Neurons Synthesizing γ -aminobutyric Acid in Cortex and Hippocampus of Adult Rats by Pesold, C., Impagnatiello, F., Pisu, M. G., Uzunov, D. P., Costa, E., Guidotti, A., Caruncho, H. J.

“…During embryonic development of brain laminated structures, the protein Reelin, secreted into the extracellular matrix of the cortex and hippocampus by…”
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Reelin influences the expression and function of dopamine D2 and serotonin 5-HT2A receptors: A comparative study by Varela, M.J, Lage, S, Caruncho, H.J, Cadavid, M.I, Loza, M.I, Brea, J

“…Highlights • There is an increased D2 and 5-HT2A receptor density in HRM striatum. • There is a decreased D2 and 5-HT2A receptor density in HRM frontal cortex…”
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The role of dopamine receptors in lymphocytes and their changes in schizophrenia by Penedo, M.A., Rivera-Baltanás, T., Pérez-Rodríguez, D., Allen, J., Borrajo, A., Alonso-Crespo, D., Fernández-Pereira, C., Nieto-Araujo, M., Ramos-García, S., Barreiro-Villar, C., Caruncho, H.J., Olivares, J.M., Agís-Balboa, R.C.

“…Dopamine and its 5 receptors, which are grouped into two families (D1-like and D2-like), modulate functions at a systemic level in both the central nervous…”
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The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus by Fournier, N.M., Andersen, D.R., Botterill, J.J., Sterner, E.Y., Lussier, A.L., Caruncho, H.J., Kalynchuk, L.E.

“…Temporal lobe seizures can induce the proliferation and abnormal migration of newly generated dentate granule cells, but little is known about the molecular…”
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Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam by Impagnatiello, F, Pesold, C, Longone, P, Caruncho, H, Fritschy, J M, Costa, E, Guidotti, A

“…We evaluated whether tolerance to the antagonism of bicuculine-induced seizures by diazepam is associated with changes (i) in the content of mRNAs encoding for…”
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Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells by Padín, J Fernando, Rodríguez, Miguel A, Domínguez, Eduardo, Dopeso-Reyes, Iria G, Buceta, Montserrat, Cano, Ernesto, Sotelo, Eddy, Brea, José, Caruncho, Hector J, Isabel Cadavid, M, Castro, Marián, Isabel Loza, M

“…Patterns of protein expression can be used to identify biomarkers of disease, prognosis or treatment response. Peripheral 5-HT2A and D3 receptors have been…”
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Treadmill running induces striatal Fos expression via NMDA glutamate and dopamine receptors by LISTE, I, GUERRA, M. J, CARUNCHO, H. J, LABANDEIRA-GARCIA, J. L

“…Several non-physiological stimuli (i.e. pharmacological or electrical stimuli) have been shown to induce Fos expression in striatal neurons. In this work,…”
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Tolerance to diazepam and changes in GABA A receptor subunit expression in rat neocortical areas by Pesold, C, Caruncho, H.J, Impagnatiello, F, Berg, M.J, Fritschy, J.-M, Guidotti, A, Costa, E

“…Long-term treatment with diazepam, a full allosteric modulator of the GABA A receptor, results in tolerance to its anticonvulsant effects, whereas an…”
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Cortical Bitufted, Horizontal, and Martinotti Cells Preferentially Express and Secrete Reelin into Perineuronal Nets, Nonsynaptically Modulating Gene Expression by Pesold, Christine, Liu, Wen Sheng, Guidotti, Alessandro, Costa, Erminio, Caruncho, Hector J.

“…Reelin (Reln) is a protein with some structural analogies with other extracellular matrix proteins that functions in the regulation of neuronal migration…”
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The density and distribution of six GABAA receptor subunits in primary cultures of rat cerebellar granule cells by CARUNCHO, H. J, PUIA, G, MOHLER, H, COSTA, E

“…In cultured cerebellar granule neurons (seven days in vitro) the expression of GABAA receptor subunits was quantified by using freeze-fracture…”
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Changes in gamma-aminobutyrate type A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro by Zheng, T M, Zhu, W J, Puia, G, Vicini, S, Grayson, D R, Costa, E, Caruncho, H J

“…The amounts of mRNAs encoding alpha 1, alpha 6, beta 2, beta 3, gamma 2, and delta subunits of gamma-aminobutyrate type A (GABAA) receptors and the gold…”
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Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts by López-Martín, Elena, Caruncho, Héctor J., Rodríguez-Pallares, Jannette, José Guerra, María, Luis Labandeira-García, José

“…Glial cell line‐derived neurotrophic factor (GDNF) has potent trophic action on fetal dopaminergic neurons. We have used a double immunocytochemical approach…”
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Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures by Zheng, T M, Caruncho, H J, Zhu, W J, Vicini, S, Ikonomovic, S, Grayson, D R, Costa, E

“…Flumazenil competitively blocks the pharmacological effects of both positive and negative allosteric modulators acting at the benzodiazepine binding sites of…”
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