SARS-CoV-2 infection in early first-trimester miscarriages: a prospective observational study

Is there an association between SARS-CoV-2 infection and first-trimester miscarriage? This multicentre prospective study included a cohort of women with first-trimester miscarriages registered consecutively by seven Spanish hospitals where universal PCR screening for SARS-CoV-2 infection was impleme...

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Published in:	Reproductive biomedicine online Vol. 44; no. 1; pp. 127 - 130
Main Authors:	González Rodríguez, Laura, Oreja Cuesta, Ana Belén, Pardo Pumar, María Isabel, Ferriols-Pérez, Elena, Pedró Carulla, Rosa, Bernardo Vega, Rut, Vaquerizo Ruiz, Óscar, de la Cruz Conty, María Luisa, Couceiro Naveira, Emilio, Marín Ortiz, Elena, Cruz Melguizo, Sara, Martínez-Pérez, Oscar
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-01-2022
Subjects:	Abortion, Spontaneous - virology Adolescent Adult COVID-19 - complications COVID-19 - epidemiology Female Humans Incidence Middle Aged Miscarriage Pregnancy Pregnancy Trimester, First Prospective Studies SARS-CoV-2 Spain - epidemiology Young Adult Spain Miscarriage SARS-CoV-2
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Summary:	Is there an association between SARS-CoV-2 infection and first-trimester miscarriage? This multicentre prospective study included a cohort of women with first-trimester miscarriages registered consecutively by seven Spanish hospitals where universal PCR screening for SARS-CoV-2 infection was implemented with both miscarriages and deliveries. The incidence of SARS-CoV-2 infection among women with first-trimester miscarriages was compared with the rate registered in women on admission to the delivery ward within the same time frame using a mixed-effects Poisson regression analysis, considering ‘hospital’ as random effect. The characteristics of SARS-CoV-2 positive and negative patients who miscarried were compared through two-sided univariable analyses. A total of 301 miscarriages were registered, 11 (3.7%) to SARS-CoV-2 infected and 290 to non-infected women. In the same time frame as the miscarriages, 1936 deliveries were registered, 44 [2.3%] of them were SARS-CoV-2 infected. No differences in terms of SARS-CoV-2 infection incidence were observed between infected miscarriages and infected deliveries (P = 0.233). Regarding the differences observed between miscarriages in SARS-CoV-2 positive and negative women, more inevitable miscarriages occurred in the group of infected women (36.4% versus 16.5% in non-infected women; P = 0.004), and there was greater surgical management of miscarriages (27.3% versus 8.2% in non-infected women; P = 0.036), probably in line with the greater number of inevitable miscarriages observed in this group. No association between SARS-CoV-2 infection and risk of first-trimester miscarriage was observed; however, the type of miscarriage seems to differ between SARS-CoV-2 positive and negative women, with inevitable miscarriage being more frequent among infected women.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Undefined-2
ISSN:	1472-6483 1472-6491
DOI:	10.1016/j.rbmo.2021.09.010