Search Results - "Carulla, Natàlia"

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage by Ciudad, Sonia, Puig, Eduard, Botzanowski, Thomas, Meigooni, Moeen, Arango, Andres S., Do, Jimmy, Mayzel, Maxim, Bayoumi, Mariam, Chaignepain, Stéphane, Maglia, Giovanni, Cianferani, Sarah, Orekhov, Vladislav, Tajkhorshid, Emad, Bardiaux, Benjamin, Carulla, Natàlia

“…Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimerʼs disease (AD). Here, we…”
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Direct Evidence of the Presence of Cross-Linked Aβ Dimers in the Brains of Alzheimer’s Disease Patients by Vázquez de la Torre, Aurelio, Gay, Marina, Vilaprinyó-Pascual, Sílvia, Mazzucato, Roberta, Serra-Batiste, Montserrat, Vilaseca, Marta, Carulla, Natàlia

“…Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer’s disease (AD). However, their covalent nature remains controversial. This feature is…”
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Somatostatin, an In Vivo Binder to Aβ Oligomers, Binds to βPFOAβ(1–42) Tetramers by Puig, Eduard, Tolchard, James, Riera, Antoni, Carulla, Natàlia

“…Somatostatin (SST14) is strongly related to Alzheimer’s disease (AD), as its levels decline during aging, it regulates the proteolytic degradation of the…”
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Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange by Carulla, Natàlia, Zhou, Min, Giralt, Ernest, Robinson, Carol V, Dobson, Christopher M

“…The aggregation of proteins into amyloid fibrils is a complex and fascinating process associated with debilitating clinical disorders such as Alzheimer’s and…”
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Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease by Pujadas, Lluís, Rossi, Daniela, Andrés, Rosa, Teixeira, Cátia M., Serra-Vidal, Bernat, Parcerisas, Antoni, Maldonado, Rafael, Giralt, Ernest, Carulla, Natàlia, Soriano, Eduardo

“…Reelin is an extracellular matrix protein that is crucial for neural development and adult brain plasticity. While the Reelin signalling cascade has been…”
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Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties by Sánchez, Laia, Madurga, Sergio, Pukala, Tara, Vilaseca, Marta, López-Iglesias, Carmen, Robinson, Carol V, Giralt, Ernest, Carulla, Natàlia

“…A critical aspect to understanding the molecular basis of Alzheimer’s disease (AD) is the characterization of the kinetics of interconversion between the…”
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Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death by Serra-Vidal, Bernat, Pujadas, Lluís, Rossi, Daniela, Soriano, Eduardo, Madurga, Sergio, Carulla, Natàlia

“…The aggregation of the amyloid-β peptide (Aβ) to form fibrils and plaques is strongly associated with Alzheimer’s disease (AD). Although it is well established…”
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Template-Assisted Lateral Growth of Amyloid-β42 Fibrils Studied by Differential Labeling with Gold Nanoparticles by Arimon, Muriel, Sanz, Fausto, Giralt, Ernest, Carulla, Natàlia

“…Amyloid-β protein (Aβ) aggregation into amyloid fibrils is central to the origin and development of Alzheimer’s disease (AD), yet this highly complex process…”
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Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation by Carulla, Natàlia, Zhou, Min, Arimon, Muriel, Gairí, Margarida, Giralt, Ernest, Robinson, Carol V, Dobson, Christopher M

“…Recent experimental evidence points to intermediates populated during the process of amyloid fibril formation as the toxic moieties primarily responsible for…”
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Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease by Serra-Batiste, Montserrat, Tolchard, James, Giusti, Fabrice, Zoonens, Manuela, Carulla, Natàlia

“…We have recently reported on the preparation of a membrane-associated β Aβ42 Oligomer (β ). It corresponds to a stable and homogeneous Aβ42 oligomer that…”
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Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease by Pujadas, Lluís, Rossi, Daniela, Andrés, Rosa, Teixeira, Cátia M., Serra-Vidal, Bernat, Parcerisas, Antoni, Maldonado, Rafael, Giralt, Ernest, Carulla, Natàlia, Soriano, Eduardo

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Retro‐Enantio N‐Methylated Peptides as β‐Amyloid Aggregation Inhibitors by Grillo‐Bosch, Dolors, Carulla, Natàlia, Cruz, Montse, Sánchez, Laia, Pujol‐Pina, Rosa, Madurga, Sergio, Rabanal, Francesc, Giralt, Ernest

“…An emerging and attractive target for the treatment of Alzheimer's disease is to inhibit the aggregation of β‐amyloid protein (Aβ). We applied the…”
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The curvature of gold nanoparticles influences the exposure of amyloid-β and modulates its aggregation process by Tapia-Arellano, Andreas, Gallardo-Toledo, Eduardo, Celis, Freddy, Rivera, Rodrigo, Moglia, Italo, Campos, Marcelo, Carulla, Natàlia, Baez, Mauricio, Kogan, Marcelo J.

“…Gold nanoparticles (GNP) are tunable nanomaterials that can be used to develop rational therapeutic inhibitors against the formation of pathological aggregates…”
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Redesign of Protein Domains Using One-Bead-One-Compound Combinatorial Chemistry by Pastor, Jose J, Granados, Giovanna, Carulla, Natàlia, Rabanal, Francesc, Giralt, Ernest

“…A novel combinatorial strategy for the redesign of proteins based on the strength and specificity of intra- and interprotein interactions is described. The…”
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Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments by Serra-Batiste, Montserrat, Ninot-Pedrosa, Martí, Bayoumi, Mariam, Gairí, Margarida, Maglia, Giovanni, Carulla, Natàlia

“…The formation of amyloid-β peptide (Aβ) oligomers at the cellular membrane is considered to be a crucial process underlying neurotoxicity in Alzheimer’s…”
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Molecular recycling within amyloid fibrils by Dobson, Christopher M, Carulla, Natàlia, Caddy, Gemma L, Hall, Damien R, Zurdo, Jesús, Gairí, Margarida, Feliz, Miguel, Giralt, Ernest, Robinson, Carol V

“…Amyloid fibrils are thread-like protein aggregates with a core region formed from repetitive arrays of β-sheets oriented parallel to the fibril axis. Such…”
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Somatostatin, an In Vivo Binder to Aβ Oligomers, Binds to βPFO Aβ(1–42) Tetramers by Puig, Eduard, Tolchard, James, Riera, Antoni, Carulla, Natàlia

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Native state hydrogen-exchange analysis of protein folding and protein motional domains by Woodward, Clare, Carulla, Natàlia, Barany, George

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Preparation of a Well-Defined and Stable β-Barrel Pore-Forming Aβ42 Oligomer by Serra-Batiste, Montserrat, Ninot-Pedrosa, Martí, Puig, Eduard, Ciudad, Sonia, Gairí, Margarida, Carulla, Natàlia

“…The formation of amyloid-β peptide (Aβ) oligomers at the cellular membrane is considered a crucial process that underlies neurotoxicity in Alzheimer's disease…”
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Direct Evidence of the Presence of Cross-Linked Aß Dimers in the Brains of Alzheimer’s Disease Patients by de la Torre, Aurelio Vázquez, Gay, Marina, Vilaprinyó-Pascual, Sílvia, Mazzucato, Roberta, Serra-Batiste, Montserrat, Vilaseca, Marta, Carulla, Natàlia

“…Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer’s disease (AD). However, their covalent nature remains controversial. This feature is…”
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