Search Results - "Carucci, D J"

DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccine Encoding Thrombospondin-Related Adhesion Protein but Not Circumsporozoite Protein Partially Protects Healthy Malaria-Naive Adults against Plasmodium falciparum Sporozoite Challenge by Dunachie, S.J, Walther, M, Epstein, J.E, Keating, S, Berthoud, T, Andrews, L, Andersen, R.F, Bejon, P, Goonetilleke, N, Poulton, I, Webster, D.P, Butcher, G, Watkins, K, Sinden, R.E, Levine, G.L, Richie, T.L, Schneider, J, Kaslow, D, Gilbert, S.C, Carucci, D.J, Hill, A.V.S

“…The safety, immunogenicity, and efficacy of DNA and modified vaccinia virus Ankara (MVA) prime-boost regimes were assessed by using either…”
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The Anopheles gambiae adult midgut peritrophic matrix proteome by Dinglasan, R.R., Devenport, M., Florens, L., Johnson, J.R., McHugh, C.A., Donnelly-Doman, M., Carucci, D.J., Yates, J.R., Jacobs-Lorena, M.

“…Malaria is a devastating disease. For transmission to occur, Plasmodium, the causative agent of malaria, must complete a complex developmental cycle in its…”
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Reduced immunogenicity of DNA vaccine plasmids in mixtures by SEDEGAH, M, CHAROENVIT, Y, NARUM, D. L, CARUCCI, D. J, ROGERS, W. O, MINH, L, BELMONTE, M, MAJAM, V. F, ABOT, S, GANESHAN, H, KUMAR, S, BACON, D. J, STOWERS, A

“…We measured the ability of nine DNA vaccine plasmids encoding candidate malaria vaccine antigens to induce antibodies and interferon-gamma responses when…”
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Utilization of genomic sequence information to develop malaria vaccines by Doolan, D L, Aguiar, J C, Weiss, W R, Sette, A, Felgner, P L, Regis, D P, Quinones-Casas, P, Yates, 3rd, J R, Blair, P L, Richie, T L, Hoffman, S L, Carucci, D J

“…Recent advances in the fields of genomics, proteomics and molecular immunology offer tremendous opportunities for the development of novel interventions…”
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The Infectivity of Plasmodium yoelii in Different Strains of Mice by Belmonte, M, Jones, T. R, Lu, M, Arcilla, R, Smalls, T, Belmonte, A, Rosenbloom, J, Carucci, D. J, Sedegah, M

“…We evaluated the effect of using Medium 199 alone and Medium 199 supplemented with 5% normal mouse serum, 5% fetal calf serum, 5% bovine serum albumin or 5%…”
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Functional proteome and expression analysis of sporozoites and hepatic stages of malaria development by Blair, P L, Carucci, D J

“…An evolution in modern malaria research occurred with the completion of the Plasmodium falciparum genome project and the onset and application of novel…”
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Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF by Sedegah, M, Charoenvit, Y, Aguiar, J, Sacci, J, Hedstrom, R, Kumar, S, Belmonte, A, Lanar, D E, Jones, T R, Abot, E, Druilhe, P, Corradin, G, Epstein, J E, Richie, T L, Carucci, D J, Hoffman, S L

“…One potential benefit of DNA vaccines is the capacity to elicit antibody and T-cell responses against multiple antigens at the same time by mixing plasmids…”
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Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle by Le Roch, Karine G., Zhou, Yingyao, Blair, Peter L., Grainger, Muni, Moch, J. Kathleen, Haynes, J. David, De la Vega, Patricia, Holder, Anthony A., Batalov, Serge, Carucci, Daniel J., Winzeler, Elizabeth A.

“…The completion of the genome sequence for Plasmodium falciparum, the species responsible for most malaria human deaths, has the potential to reveal hundreds of…”
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From genomics to vaccines: Malaria as a model system by Hoffman, Stephen L, Rogers, William O, Carucci, Daniel J, Venter, J. Craig

“…Stephen Hoffman and colleagues from the Naval Medical Research Center and J. Craig Venter from TIGR propose a strategy for applying the wealth of information…”
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A shotgun optical map of the entire Plasmodium falciparum genome by Schwartz, David C, Lai, Zhongwu, Jing, Junping, Aston, Christopher, Clarke, Virginia, Apodaca, Jennifer, Dimalanta, Eileen T, Carucci, Daniel J, Gardner, Malcolm J, Mishra, Bud, Anantharaman, Thomas S, Paxia, Salvatore, Hoffman, Stephen L, Venter, J. Craig, Huff, Edward J

“…The unicellular parasite Plasmodium falciparum is the cause of human malaria, resulting in 1.7-2.5 million deaths each year. To develop new means to treat or…”
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Functional genomic technologies applied to the control of the human malaria parasite, Plasmodium falciparum by Carucci, D J

“…Infection with any of the four species of Plasmodium single cell parasites that infects humans causes the clinical disease, malaria. Of these, it is Plasmodium…”
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Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice by SANCHEZ, Gloria I, SEDEGAH, Martha, ROGERS, William O, JONES, Trevor R, SACCI, John, WITNEY, Adam, CARUCCI, Daniel J, KUMAR, Nirbhay, HOFFMAN, Stephen L

“…The gene encoding the 60-kDa heat shock protein of Plasmodium yoelii (PyHsp60) was cloned into the VR1012 and VR1020 mammalian expression vectors. Groups of 10…”
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Identification of Plasmodium falciparum Antigens by Antigenic Analysis of Genomic and Proteomic Data by Doolan, Denise L., Southwood, Scott, Freilich, Daniel A., Sidney, John, Graber, Norma L., Shatney, Lori, Bebris, Lolita, Florens, Laurence, Dobano, Carlota, Witney, Adam A., Appella, Ettore, Hoffman, Stephen L., Yates, John R., Carucci, Daniel J., Sette, Alessandro

“…The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for…”
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A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling by Sam-Yellowe, Tobili Y, Florens, Laurence, Johnson, Jeffrey R, Wang, Tongmin, Drazba, Judith A, Le Roch, Karine G, Zhou, Yingyao, Batalov, Serge, Carucci, Daniel J, Winzeler, Elizabeth A, Yates, 3rd, John R

“…Upon invasion of the erythrocyte cell, the malaria parasite remodels its environment; in particular, it establishes a complex membrane network, which connects…”
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Plasmodium falciparum:Parasite Typing by Using a Multicopy Microsatellite Marker, PfRRM by Su, Xin-Zhuan, Carucci, Daniel J., Wellems, Thomas E.

“…Su, X.-Z., Carucci, D. J., and Wellems, T. E. 1998.Plasmodium falciparum:Parasite typing by using a multicopy microsatellite marker, PfRRM.Experimental…”
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Induction of CD4+T Cell-Dependent CD8+Type 1 Responses in Humans by a Malaria DNA Vaccine by Wang, Ruobing, Epstein, Judith, Baraceros, Fe Maria, Gorak, Edward J., Charoenvit, Yupin, Carucci, Daniel J., Hedstrom, Richard C., Rahardjo, Nancy, Gay, Tanya, Hobart, Peter, Stout, Rick, Jones, Trevor R., Richie, Thomas L., Parker, Suezanne E., Doolan, Denise L., Norman, Jon, Hoffman, Stephen L.

“…We assessed immunogenicity of a malaria DNA vaccine administered by needle i.m. or needleless jet injection [i.m. or i.m./intradermally (i.d.)] in 14…”
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Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A by Epstein, Judith E, Charoenvit, Yupin, Kester, Kent E, Wang, Ruobing, Newcomer, Rhonda, Fitzpatrick, Steve, Richie, Thomas L, Tornieporth, Nadia, Heppner, D.Gray, Ockenhouse, Chris, Majam, Victoria, Holland, Carolyn, Abot, Esteban, Ganeshan, Harini, Berzins, Mara, Jones, Trevor, Freydberg, C.Nicole, Ng, Jennifer, Norman, Jon, Carucci, Daniel J, Cohen, Joe, Hoffman, Stephen L

“…Optimal protection against malaria may require induction of high levels of protective antibody and CD8 + and CD4 + T cell responses. In humans, malaria DNA…”
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Plasmodium yoelii: Cloning and Characterization of the Gene Encoding for the Mitochondrial Heat Shock Protein 60 by Sanchez, Gloria I., Carucci, Daniel J., Sacci, John, Resau, James H., Rogers, William O., Kumar, Nirbhay, Hoffman, Stephen L.

“…Sanchez, G. I., Carucci, D. J., Sacci, J., Jr., Resau, J. H., Rogers, W. O., Kumar, N., and Hoffman, S. L. 1999. Plasmodium yoelii: Cloning and…”
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Exploring the Transcriptome of the Malaria Sporozoite Stage by Stefan H. I. Kappe, Gardner, Malcolm J., Brown, Stuart M., Ross, Jessica, Matuschewski, Kai, Ribeiro, Jose M., Adams, John H., Quackenbush, John, Cho, Jennifer, Carucci, Daniel J., Hoffman, Stephen L., Nussenzweig, Victor

“…Most studies of gene expression in Plasmodium have been concerned with asexual and/or sexual erythrocytic stages. Identification and cloning of genes expressed…”
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PfSPATR, a Plasmodium falciparum Protein Containing an Altered Thrombospondin Type I Repeat Domain Is Expressed at Several Stages of the Parasite Life Cycle and Is the Target of Inhibitory Antibodies by Chattopadhyay, Rana, Rathore, Dharmendar, Fujioka, Hishasi, Kumar, Sanjai, de la Vega, Patricia, Haynes, David, Moch, Kathleen, Fryauff, David, Wang, Ruobing, Carucci, Daniel J., Hoffman, Stephen L.

“…The annotated sequence of chromosome 2 of Plasmodium falciparum was examined for genes encoding proteins that may be of interest for vaccine development. We…”
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