Search Results - "Carty, T J"

Impaired Inflammatory and Pain Responses in Mice Lacking an Inducible Prostaglandin E Synthase by Trebino, Catherine E., Stock, Jeffrey L., Gibbons, Colleen P., Naiman, Brian M., Wachtmann, Timothy S., Umland, John P., Pandher, Karamjeet, Lapointe, Jean-Martin, Saha, Sipra, Roach, Marsha L., Carter, Demetrius, Thomas, Nathalie A., Durtschi, Becky A., McNeish, John D., Hambor, John E., Jakobsson, Per-Johan, Carty, Thomas J., Perez, Jose R., Audoly, Laurent P.

“…Prostaglandin (PG)E2is a potent mediator of pain and inflammation, and high levels of this lipid mediator are observed in numerous disease states. The…”
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IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin by Perregaux, D, Barberia, J, Lanzetti, AJ, Geoghegan, KF, Carty, TJ, Gabel, CA

“…Mouse peritoneal macrophages stimulated with LPS produce large amounts of pro-IL-1 beta. When these cells were pulse-labeled with [35S]methionine, however,…”
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Tenidap, a structurally novel drug for the treatment of arthritis: antiinflammatory and analgesic properties by Moore, P F, Larson, D L, Otterness, I G, Weissman, A, Kadin, S B, Sweeney, F J, Eskra, J D, Nagahisa, A, Sakakibara, M, Carty, T J

“…Tenidap is a new anti-rheumatic agent which has clinical properties characteristic of a disease modifying drug combined with acute antiinflammatory and…”
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Inhibitory effect of UK,74505, a potent and specific oral platelet activating factor (PAF) receptor antagonist, on airway and systemic responses to inhaled PAF in humans by O'Connor, B J, Uden, S, Carty, T J, Eskra, J D, Barnes, P J, Chung, K F

“…Inhaled PAF provokes bronchoconstriction, causes peripheral blood neutropenia with rebound neutrophilia, and generates urinary production of the…”
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Effect of tumor necrosis factor‐α converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons by Blacker, Megan, Noe, Mark C., Carty, Thomas J., Goodyer, Cynthia G., LeBlanc, Andréa C.

“…Tumor necrosis factor‐α (TNF‐α) is implicated in inflammatory processes and much effort is being directed at inhibiting the release of TNF‐α for treatment of…”
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Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models by Carty, T J, Sweeney, F J, Griffiths, R J, Eskra, J D, Ernest, M J, Pillar, J S, Cheng, J D, Loose, L D, Joseph, P A, Pazoles, P P, Moore, P F, Nagahisa, A, Murase, S, Kadin, S B

“…The effect of tenidap on the metabolism of arachidonic acid via the 5-lipoxygenase (5-LO) pathway was investigated in vitro and in vivo. In vitro (cells)…”
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Indeno[1,2-c]pyrazolone acetic acids as semirigid analogues of the nonsteroidal anti-inflammatory drugs by Lemke, T L, Abebe, E, Moore, P F, Carty, T J

“…A series of 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-2-acetic acids (3a-e) and 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-1-acetic acids (4a-e) were…”
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Regulation of glycogen phosphorylase. Role of the peptide region surrounding the phosphoserine residue in determining enzyme properties by Carty, T J, Tu J-I, Graves, D J

“…A phosphopeptide which contains 14 residues including phosphoserine and which is derived from the NH2-terminal region of skeletal muscle glycogen phosphorylase…”
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The biochemistry and pharmacology of TNF alpha and beta, 21 April 1995, New York by Carty, T J, Gilman, S C

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Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis by Blackburn, Jr, W D, Heck, L W, Loose, L D, Eskra, J D, Carty, T J

“…We studied the effect of tenidap sodium, a new antiinflammatory/antirheumatic drug (120 mg/day for 7 days), on eicosanoid production and neutrophil…”
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New Insights into Disintegrin Metalloproteases by Carty, T J, LoPresti-Morrow, L L, Mitchell, P G, McNiff, P A, McClure, K F

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Pyridoxal phosphate-dependent conformational states of glycogen phosphorylase as probed by interconverting enzymes by Graves, D J, Carlson, G M, Skuster, J R, Parrish, R F, Carty, T J, Tessmer, G W

“…The interaction between pyridoxal 5'-phosphate and the convertible serine of glycogen phosphorylase has been investigated by using: specific interconverting…”
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Spectrophotometric monitoring of lipoxygenase and cyclooxygenase pathway activity using ionophore stimulated whole blood by Sweeney, F J, Eskra, J D, Ernest, M J, Carty, T J

“…We have employed clotting human blood stimulated with ionophore to develop a system for measuring cyclooxygenase, 5-lipoxygenase, and 12-lipoxygenase pathway…”
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The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. The reversible formation of 5'-deoxyadenosine from adenosylcobalamin during the catalytic process by Babior, B M, Carty, T J, Abeles, R H

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1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity by Mylari, B L, Carty, T J, Moore, P F, Zembrowski, W J

“…A series of 1,2-dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine, 1,2-dihydro-1-oxopyrrolo[3,2,1-kl]phenoxazine, and…”
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Development of a system for evaluating 5-lipoxygenase inhibitors using human whole blood by Sweeney, F J, Eskra, J D, Carty, T J

“…A reliable system for evaluating 5-lipoxygenase (5-LO) pathway inhibitors employing human whole blood stimulated by the calcium ionophore, A-23187, and yeast…”
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Theoretical and Experimental Design of Atypical Kinase Inhibitors:  Application to p38 MAP Kinase by McClure, Kim F, Abramov, Yuriy A, Laird, Ellen R, Barberia, John T, Cai, Weiling, Carty, Thomas J, Cortina, Santo R, Danley, Dennis E, Dipesa, Alan J, Donahue, Kathleen M, Dombroski, Mark A, Elliott, Nancy C, Gabel, Christopher A, Han, Seungil, Hynes, Thomas R, LeMotte, Peter K, Mansour, Mahmoud N, Marr, Eric S, Letavic, Michael A, Pandit, Jayvardhan, Ripin, David B, Sweeney, Francis J, Tan, Douglas, Tao, Yong

“…Mimics of the benzimidazolone nucleus found in inhibitors of p38 kinase are proposed, and their theoretical potential as bioisosteres is described. A set of…”
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The Corrosion of Certain Metals by Carbon Tetrachloride by Rhodes, F. H, Carty, J. T

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The use of 12-hydroxyheptadecatrienoic acid (HHT) as an HPLC/spectrophotometric marker for cyclooxygenase pathway activity in resident rat peritoneal cells by Sweeney, F J, Pereira, M J, Eskra, J D, Carty, T J

“…12-Hydroxyheptadecatrienoic acid (HHT), a UV chromophore, has been used to assess cyclooxygenase (CO) pathway metabolism of arachidonic acid (AA) by rat…”
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The biochemistry and pharmacology of interleukins-1 and -6 by Carty, T. J., Laliberte, R. E.

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