Search Results - "Carty, Shannon"

Biological insights into the role of TET2 in T cell lymphomas by Carty, Shannon A.

“…Peripheral T cell lymphomas (PTCL) are a heterogenous group of mature T cell lymphomas with an overall poor prognosis. Understanding the molecular…”
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Immunology 101: fundamental immunology for the practicing hematologist by Carty, Shannon A

“…From an evolutionary perspective, the immune system developed primarily to protect the host from pathogens. In the continuous balance between killing pathogens…”
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Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells by Fraietta, Joseph A., Nobles, Christopher L., Sammons, Morgan A., Lundh, Stefan, Carty, Shannon A., Reich, Tyler J., Cogdill, Alexandria P., Morrissette, Jennifer J. D., DeNizio, Jamie E., Reddy, Shantan, Hwang, Young, Gohil, Mercy, Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Chen, Fang, Everett, John K., Alexander, Katherine A., Lin-Shiao, Enrique, Gee, Marvin H., Liu, Xiaojun, Young, Regina M., Ambrose, David, Wang, Yan, Xu, Jun, Jordan, Martha S., Marcucci, Katherine T., Levine, Bruce L., Garcia, K. Christopher, Zhao, Yangbing, Kalos, Michael, Porter, David L., Kohli, Rahul M., Lacey, Simon F., Berger, Shelley L., Bushman, Frederic D., June, Carl H., Melenhorst, J. Joseph

“…Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies 1 – 3 . In this strategy, the T cell…”
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The Loss of TET2 Promotes CD8 + T Cell Memory Differentiation by Carty, Shannon A, Gohil, Mercy, Banks, Lauren B, Cotton, Renee M, Johnson, Matthew E, Stelekati, Erietta, Wells, Andrew D, Wherry, E John, Koretzky, Gary A, Jordan, Martha S

“…T cell differentiation requires appropriate regulation of DNA methylation. In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven…”
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DNA Methylation in T-Cell Development and Differentiation by Correa, Luis O, Jordan, Martha S, Carty, Shannon A

“…T lymphocytes undergo carefully orchestrated programming during development in the thymus and subsequently during differentiation in the periphery. This…”
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Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation by Carty, Shannon A, Koretzky, Gary A, Jordan, Martha S

“…Interleukin (IL)-4 is a cytokine classically associated with CD4(+) T helper type 2 differentiation, but has been recently shown to also be required for the…”
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Two cases of challenging cutaneous lymphoid infiltrates presenting in the context of COVID‐19 vaccination: A reactive lymphomatoid papulosis‐like eruption and a bona fide lymphoma by Bresler, Scott C., Menge, Tyler D., Tejasvi, Trilokraj, Carty, Shannon A., Hristov, Alexandra C.

“…COVID‐19 infection and vaccination may be associated with a wide variety of cutaneous and immune manifestations. Here, we describe two patients who presented…”
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SOHO State of the Art Updates and Next Questions | New Pathways and New Targets in PTCL: Staying on Target by Carty, Shannon A., Murga-Zamalloa, Carlos A., Wilcox, Ryan A.

“…While the peripheral T-cell lymphomas (PTCL) remain a therapeutic challenge, and increasingly account for a disproportionate number of lymphoma-related deaths,…”
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Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways by Lenz, Georg, Wright, George W, Emre, N.C. Tolga, Kohlhammer, Holger, Dave, Sandeep S, Davis, R. Eric, Carty, Shannon, Lam, Lloyd T, Shaffer, A.L, Xiao, Wenming, Powell, John, Rosenwald, Andreas, Ott, German, Muller-Hermelink, Hans Konrad, Gascoyne, Randy D, Connors, Joseph M, Campo, Elias, Jaffe, Elaine S, Delabie, Jan, Smeland, Erlend B, Rimsza, Lisa M, Fisher, Richard I, Weisenburger, Dennis D, Chan, Wing C, Staudt, Louis M

“…Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB)…”
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Germline POT1 variants can predispose to myeloid and lymphoid neoplasms by Lim, Tristan L., Lieberman, David B., Davis, Adam R., Loren, Alison W., Hausler, Ryan, Bigdeli, Ashkan, Li, Yimei, Powers, Jacquelyn, Raper, Anna, Regeneron Genetics Center, Carty, Shannon A., Nathanson, Katherine L., Bagg, Adam, Hexner, Elizabeth O., Maxwell, Kara N., Morrissette, Jennifer J. D., Babushok, Daria V.

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Metabolomic Profiles of Human Glioma Inform Patient Survival by Scott, Andrew J, Correa, Luis O, Edwards, Donna M, Sun, Yilun, Ravikumar, Visweswaran, Andren, Anthony C, Zhang, Li, Srinivasan, Sudharsan, Jairath, Neil, Verbal, Kait, Muraszko, Karin, Sagher, Oren, Carty, Shannon A, Hervey-Jumper, Shawn, Orringer, Daniel, Kim, Michelle M, Junck, Larry, Umemura, Yoshie, Leung, Denise, Venneti, Sriram, Camelo-Piragua, Sandra, Lawrence, Theodore S, Ippolito, Joseph E, Al-Holou, Wajd N, Chinnaiyan, Prakash, Heth, Jason, Rao, Arvind, Lyssiotis, Costas A, Wahl, Daniel R

“…Targeting tumor metabolism may improve the outcomes for patients with glioblastoma (GBM). To further preclinical efforts targeting metabolism in GBM, we tested…”
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection by Correa-Medero, Luis O., Jankowski, Shayna E., Hong, Hanna S., Armas, Nicholas D., Vijendra, Aditi I., Reynolds, Mack B., Fogo, Garrett M., Awad, Dominik, Dils, Alexander T., Inoki, Kantaro A., Williams, Reid G., Ye, Annabelle M., Svezhova, Nadezhda, Gomez-Rivera, Francisco, Collins, Kathleen L., O’Riordan, Mary X., Sanderson, Thomas H., Lyssiotis, Costas A., Carty, Shannon A.

“…The maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and immunotherapies. Pathways contributing to CD8+ T cell loss are not…”
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The physical exam’s role in determining dose-limiting toxicity prior to immunochemotherapy administration in lymphoma by Runge, John S., Brown, Anna B., Phillips, Tycel J., Kaminski, Mark S., Carty, Shannon A., Wilcox, Ryan A.

“…Introduction The COVID-19 pandemic has introduced new challenges to healthcare access and delivery. It is critical to identify areas for innovation within…”
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Clinical application of next generation sequencing in lymphoma by Scott, Anthony J., Tokaz, Molly C., Shango, Maryann, Devata, Sumana, Carty, Shannon A., Kaminski, Mark S., Chinnaiyan, Arul M., Phillips, Tycel J., Wilcox, Ryan A.

“…Successful treatment of relapsed/refractory and rare subtypes of lymphomas remains a therapeutic challenge. Though the use of tumor profiling is increasing,…”
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Adding venetoclax to lenalidomide and rituximab is safe and effective in patients with untreated mantle cell lymphoma by Phillips, Tycel J., Bond, David, Takiar, Radihka, Kump, Karson, Kandarpa, Malalthi, Boonstra, Philip, Mayer, Tera Lynn, Nachar, Victoria, Wilcox, Ryan A., Carty, Shannon A., Karimi, Yasmin H., Nikolovska-Coleska, Zaneta, Kaminski, Mark S., Herrera, Alex F., Maddocks, Kami, Popplewell, Leslie, Danilov, Alexey V.

“…•Venetoclax can be added to lenalidomide and rituximab without the occurrence of any dose-limiting toxicity in patients with untreated MCL.•Venetoclax and R2…”
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Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways by Prince, Amanda L, Kraus, Zachary, Carty, Shannon A, Ng, Caleb, Yin, Catherine C, Jordan, Martha S, Schwartzberg, Pamela L, Berg, Leslie J

“…T cell development in the thymus produces multiple lineages of cells, including innate T cells such as γδ TCR(+) cells, invariant NKT cells, mucosal-associated…”
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Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells by Gordon, Scott M, Carty, Shannon A, Kim, Jiyeon S, Zou, Tao, Smith-Garvin, Jennifer, Alonzo, Eric S, Haimm, Ethan, Sant'Angelo, Derek B, Koretzky, Gary A, Reiner, Steven L, Jordan, Martha S

“…Conventional and nonconventional T cell development occur in the thymus. Nonconventional thymocytes that bear characteristics typically associated with innate…”
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The Retinoblastoma Protein Acts as a Transcriptional Coactivator Required for Osteogenic Differentiation by Thomas, David M, Carty, Shannon A, Piscopo, Denise M, Lee, Jong-Seo, Wang, Wen-Fang, Forrester, William C, Hinds, Philip W

“…The incidence of osteosarcoma is increased 500-fold in patients who inherit mutations in the RB gene. To understand why the retinoblastoma protein (pRb) is…”
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OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment by Hong, Hanna S, Mbah, Nneka E, Shan, Mengrou, Loesel, Kristen, Lin, Lin, Sajjakulnukit, Peter, Correa, Luis O, Andren, Anthony, Lin, Jason, Hayashi, Atsushi, Magnuson, Brian, Chen, Judy, Li, Zhaoheng, Xie, Yuying, Zhang, Li, Goldstein, Daniel R, Carty, Shannon A, Lei, Yu Leo, Opipari, Anthony W, Argüello, Rafael J, Kryczek, Ilona, Kamada, Nobuhiko, Zou, Weiping, Franchi, Luigi, Lyssiotis, Costas A

“…T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered…”
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Adult-onset hydroa vacciniforme-like lymphoma in a long-term resident of the United States by Yu, Kenneth K., Franzblau, Lauren, Fullen, Douglas R., Carty, Shannon A., Tejasvi, Trilokraj

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