Search Results - "Cartwright, C A"

A novel pro-apoptotic function of RACK1: suppression of Src activity in the intrinsic and Akt pathways by Mamidipudi, V, Cartwright, C A

“…Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G 1 and mitotic checkpoints. Here, we show that RACK1 also…”
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RACK1 inhibits colonic cell growth by regulating Src activity at cell cycle checkpoints by MAMIDIPUDI, V, DHILLON, N. K, PARMAN, T, MILLER, L. D, LEE, K. C, CARTWRIGHT, C. A

“…Previously, we showed that Src tyrosine kinases are activated early in the development of human colon cancer and are suppressed as intestinal cells…”
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Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis by Swaminathan, G, Cartwright, C A

“…E-cadherin and its cytoplasmic partners, catenins, mediate epithelial cell–cell adhesion. Disruption of this adhesion allows cancer cells to invade and…”
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Src activation in malignant and premalignant epithelia of Barrett's esophagus by Kumble, S, Omary, MB, Cartwright, CA, Triadafilopoulos, G

“…BACKGROUND & AIMS: The neoplastic progression of Barrett's esophagus (BE) may involve genomic instability, inactivation of tumor suppressor genes, or…”
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Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis by CARTWRIGHT, C. A, MEISLER, A. I, ECKHART, W

“…Colonic neoplasia provides an opportunity to study tumor progression because most carcinomas arise from adenomas (polyps), which, in turn, arise from normal…”
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pp60c-src activation in human colon carcinoma by CARTWRIGHT, C. A, KAMPS, M. P, MEISLER, A. I, PIPAS, J. M, ECKHART, W

“…We measured the in vitro protein-tyrosine kinase activity of pp60c-src from human colon carcinoma cell lines and tumors. The activity of pp60c-src from six of…”
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The Shp-2 tyrosine phosphatase activates the Src tyrosine kinase by a non-enzymatic mechanism by WALTER, A. O, PENG, Z.-Y, CARTWRIGHT, C. A

“…Previously, we demonstrated that the Src tyrosine kinase interacts with the Shp-2 tyrosine phosphatase. To determine whether Shp-2 regulates Src kinase…”
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Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis by Cartwright, C A, Coad, C A, Egbert, B M

“…Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with a high incidence of colon cancer. Dysplasia is a precursor to carcinoma and a…”
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c-Yes tyrosine kinase activity in human colon carcinoma by Park, J, Meisler, A I, Cartwright, C A

“…To examine the role of Src-related proteins in human colon carcinoma we measured the tyrosine kinase activity of pp60c-src (Src), p62c-yes (Yes), p56lck (Lck),…”
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Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain by Cartwright, C A, Eckhart, W, Simon, S, Kaplan, P L

“…We introduced two mutations into the carboxy-terminal regulatory region of chicken pp60c-src. One, F527, replaces tyrosine 527 with phenylalanine. The other,…”
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Tyr527 is phosphorylated in pp60c-src: implications for regulation by COOPER, J. A, GOULD, K. L, CARTWRIGHT, C. A, HUNTER, T

“…The Rous sarcoma virus oncogene product, pp60v-src, transforms cultured fibroblasts but its corresponding proto-oncogene product, pp60c-src, does not. Both…”
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Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells by Park, Joosang, Cartwright, Christine A.

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Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen by CARTWRIGHT, C. A, KAPLAN, P. L, COOPER, J. A, HUNTER, T, ECKHART, W

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Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum by CARTWRIGHT, C. A, SIMANTOV, R, KAPLAN, P. L, HUNTER, T, ECKHART, W

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The Interaction of Src and RACK1 Is Enhanced by Activation of Protein Kinase C and Tyrosine Phosphorylation of RACK1 by Chang, Betty Y., Chiang, Meiling, Cartwright, Christine A.

“…RACK1 is an intracellular receptor for the serine/ threonine protein kinase C. Previously, we demonstrated that RACK1 also interacts with the Src…”
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The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonine kinase by Wu, J Y, Zhou, Z Y, Judd, A, Cartwright, C A, Robinson, W S

“…To study the functional mechanism of the hepatitis B virus (HBV) X (hbx) gene product, we have expressed the hbx protein in E. coli and purified it by HPLC…”
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Intestinal crypt cells contain higher levels of cytoskeletal-associated pp60c-src protein tyrosine kinase activity than do differentiated enterocytes by Cartwright, C A, Mamajiwalla, S, Skolnick, S A, Eckhart, W, Burgess, D R

“…Undifferentiated crypt cells from chicken small intestine contain 15-fold higher levels of tyrosine-phosphorylated proteins than do differentiated enterocytes…”
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Synergistic action of cyclic adenosine monophosphate- and calcium-mediated chloride secretion in a colonic epithelial cell line by CARTWRIGHT, C. A, MCROBERTS, J. A, MANDEL, K. G, DHARMSATHAPHORN, K

“…Vasoactive intestinal polypeptide (VIP) and the calcium ionophore A23187 caused dose-dependent changes in the potential difference and the short circuit…”
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Early activation of endogenous pp60src kinase activity during neuronal differentiation of cultured human neuroblastoma cells by Bjelfman, C, Meyerson, G, Cartwright, C A, Mellström, K, Hammerling, U, Påhlman, S

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RACK1, a Receptor for Activated C Kinase and a Homolog of the β Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells by Chang, Betty Y., Conroy, Karen B., Machleder, Eric M., Cartwright, Christine A.

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