Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects

Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects

Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an ath...

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Published in:Journal of diabetes research Vol. 2017; no. 2017; pp. 1 - 8
Main Authors: Figueiredo Neto, Antônio M., Freitas, Maria C. P. de, Dias, Gabriela D., Cartolano, Flávia De C., Damasceno, Nágila R. T.
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2017
Hindawi
Hindawi Limited
Subjects:
Adult
Age
Aged
Apolipoproteins
Atherosclerosis - metabolism
Blood Glucose - metabolism
Blood pressure
Body mass index
Cholesterol
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diabetes
Female
Genotype & phenotype
Glucose
Glucose Tolerance Test
Homeostasis
Humans
Insulin resistance
Insulin Resistance - physiology
Lipoproteins
Lipoproteins - blood
Male
Middle Aged
Questionnaires
Regression analysis
Risk Factors
Statistical analysis
Brazil
United States > US
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Summary:Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. The impact of IR as a predictor of atherogenic lipoproteins was tested by logistic regression analysis in raw and adjusted models. Results. HDL-C and Apo AI were significantly lower in individuals with IR. Individuals with IR had a higher percentage of small HDL particles, lower percentage in the larger ones, and reduced frequency of phenotype A (IR = 62%; non-IR = 83%). IR individuals had reduced probability to have large HDL (OR = 0.213; CI = 0.999–0.457) and had twice more chances to show increased small HDL (OR = 2.486; CI = 1.341–7.051). IR was a significant predictor of small LDL (OR = 3.075; CI = 1.341–7.051) and atherogenic phenotype (OR = 3.176; CI = 1.469–6.867). Conclusion. IR, previously DM2 diagnosis, is a strong predictor of quantitative and qualitative features of lipoproteins directly associated with an increased atherogenic risk.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Joseph F. Ndisang
ISSN:2314-6745
2314-6753
DOI:10.1155/2017/1018796