Search Results - "Carter, Rebecca W."

Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes by Lewin, Matthew R, Carter, Rebecca W, Matteo, Isabel A, Samuel, Stephen P, Rao, Sunita, Fry, Bryan G, Bickler, Philip E

“…The availability of effective, reliably accessible, and affordable treatments for snakebite envenoming is a critical and long unmet medical need. Recently,…”
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Cold Finger: Raynaud Phenomenon Following Snakebite Envenoming by Nikolsky’s Viper (Vipera berus nikolskii) by Zinenko, Oleksandr, Durkin, Daniela M, Carter, Rebecca W, Ritter, Brandi, Lewin, Matthew R

“…A field biologist was bitten by a female Nikolsky’s viper (Vipera berus nikolskii) in Kharkiv Oblast, Ukraine. Two months later, the patient began to…”
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The BRAVO Clinical Study Protocol: Oral Varespladib for Inhibition of Secretory Phospholipase A2 in the Treatment of Snakebite Envenoming by Carter, Rebecca W, Gerardo, Charles J, Samuel, Stephen P, Kumar, Surendra, Kotehal, Suneetha D, Mukherjee, Partha P, Shirazi, Farshad M, Akpunonu, Peter D, Bammigatti, Chanaveerappa, Bhalla, Ashish, Manikath, Neeraj, Platts-Mills, Timothy F, Lewin, Matthew R

“…Snakebite is an urgent, unmet global medical need causing significant morbidity and mortality worldwide. Varespladib is a potent inhibitor of venom secretory…”
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Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan Oxyuranus scutellatus Venoms by Gilliam, Lyndi L, Gilliam, John, Samuel, Stephen P, Carter, Rebecca W, Ritchey, Jerry, Bulfone, Tommaso, Gutiérrez, José María, Williams, David J, Durkin, Daniela M, Stephens, Sally I, Lewin, Matthew R

“…Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many…”
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Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathways by Chowdhury, Abhinandan, Lewin, Matthew R., Carter, Rebecca W., Casewell, Nicholas R., Fry, Bryan G.

“…Venoms are evolutionary novelties that have real-world implications due to their impact upon human health. However, relative to the abundant studies of elapid…”
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The relative efficacy of chemically diverse small-molecule enzyme-inhibitors against anticoagulant activities of Black Snake (Pseudechis spp.) venoms by Chowdhury, Abhinandan, Youngman, Nicholas J., Liu, Jiaojiao, Lewin, Matthew R., Carter, Rebecca W., Fry, Bryan G.

“…Snakebite remains a worldwide public health burden and a severely neglected tropical disease. Recent research has begun to focus on the potential use of…”
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In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib by Chowdhury, Abhinandan, Fry, Bryan G., Samuel, Stephen P., Bhalla, Ashish, Vaiyapuri, Sakthi, Bhargava, Parul, Carter, Rebecca W., Lewin, Matthew R.

“…Bungarus (krait) envenomings are well-known for their life-threatening neurotoxic effects. However, their impact on coagulation remains largely unexplored…”
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Oral varespladib for the treatment of snakebite envenoming in India and the USA (BRAVO): a phase II randomised clinical trial by Gerardo, Charles J, Carter, Rebecca W, Kumar, Surendra, Shirazi, Farshad M, Kotehal, Suneetha D, Akpunonu, Peter D, Bhalla, Ashish, Schwartz, Richard B, Bammigatti, Chanaveerappa, Manikath, Neeraj, Mukherjee, Partha P, Arnold, Thomas C, Wolk, Brian J, S Sheikh, Sophia, Sollee, Dawn R, Vearrier, David J, Francis, Samuel J, Aizenberg, Adiel, Kumar, Harish, Ravikumar, Madhu K, Sarkar, Sujoy, Haston, Taylor, Micciche, Andrew, Oomman, Suraj C, Owen, Jeffery L, Ritter, Brandi A, Samuel, Stephen P, Lewin, Matthew R, Platts-Mills, Timothy F

“…Snakebite envenoming (SBE) results in over 500 000 deaths or disabling injuries annually. Varespladib methyl, an oral inhibitor of secretory phospholipase A2,…”
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Mechanism of enhanced calcium sensitivity and alpha 2-AR vasoreactivity in chronic NOS inhibition hypertension by Carter, Rebecca W, Kanagy, Nancy L

“…PKC augments calcium sensitivity in spontaneously hypertensive rats and contributes to alpha(2)-adrenergic receptor (AR) contraction in rabbit saphenous vein…”
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Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan IOxyuranus scutellatus/I Venoms by Gilliam, Lyndi L, Gilliam, John, Samuel, Stephen P, Carter, Rebecca W, Ritchey, Jerry, Bulfone, Tommaso, Gutiérrez, José María, Williams, David J, Durkin, Daniela M, Stephens, Sally I, Lewin, Matthew R

“…Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many…”
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LABORATORY DEMONSTRATION OF VASCULAR SMOOTH MUSCLE FUNCTION USING RAT AORTIC RING SEGMENTS by Gonzales, R. J, Carter, R. W, Kanagy, N. L

“…This laboratory exercise uses a simple preparation and a straightforward protocol to illustrate many of the basic principles of vascular biology covered in an…”
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Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta by Carter, Rebecca W, Begaye, McKenzie, Kanagy, Nancy L

“…We demonstrated that arteries from rats made hypertensive with chronic nitric oxide (NO) synthase (NOS) inhibition (N(omega)-nitro-L-arginine in drinking…”
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Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta by Carter, Rebecca W, Kanagy, Nancy L

“…We have demonstrated enhanced contractile sensitivity to the alpha(2)-adrenoreceptor (alpha(2)-AR) agonist UK-14304 in arteries from rats made hypertensive…”
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Cold Finger: Raynaud Phenomenon Following Snakebite Envenoming by Nikolsky's Viper (Vipera berus nikolskii) by Zinenko, Oleksandr, Durkin, Daniela M, Carter, Rebecca W, Ritter, Brandi, Lewin, Matthew R

“…A field biologist was bitten by a female Nikolsky's viper (Vipera berus nikolskii) in Kharkiv Oblast, Ukraine. Two months later, the patient began to…”
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Mechanism of augmented alpha 2 adrenergic receptor contraction in aorta from chronic nitric oxide synthase inhibited hypertensive rats by Carter, Rebecca W

“…Hypertension effects 25% of Western adults and increases risk of cardiovascular disease. Endothelium-denuded aortic rings from rats made hypertensive with NOS…”
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Mechanism of augmented alpha 2 adrenergic receptor contraction in aorta from chronic nitric oxide synthase inhibited hypertensive rats by Carter, Rebecca W

“…Hypertension effects 25% of Western adults and increases risk of cardiovascular disease. Endothelium-denuded aortic rings from rats made hypertensive with NOS…”
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