Search Results - "Carter, Kyle P."

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11 by Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J

“…Two screening approaches converge on capzimin, a first-in-class inhibitor of the Rpn11 protease component of the 19S proteasome. Capzimin stabilizes…”
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Critical Comparison of FRET-Sensor Functionality in the Cytosol and Endoplasmic Reticulum and Implications for Quantification of Ions by Carter, Kyle P, Carpenter, Margaret C, Fiedler, Brett, Jimenez, Ralph, Palmer, Amy E

“…Genetically encoded sensors based on fluorescence resonance energy transfer (FRET) are powerful tools for quantifying and visualizing analytes in living cells,…”
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Droplet Microfluidic Flow Cytometer For Sorting On Transient Cellular Responses Of Genetically-Encoded Sensors by Fiedler, Brett L, Van Buskirk, Steven, Carter, Kyle P, Qin, Yan, Carpenter, Margaret C, Palmer, Amy E, Jimenez, Ralph

“…Fluorescent biosensors are important measurement tools for in vivo quantification of pH, concentrations of metal ions and other analytes, and physical…”
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Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR by Simons, Jan Fredrik, Lim, Yoong Wearn, Carter, Kyle P, Wagner, Ellen K, Wayham, Nicholas, Adler, Adam S, Johnson, David S

“…affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and affinity…”
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Fluorescent Sensors for Measuring Metal Ions in Living Systems by Carter, Kyle P, Young, Alexandra M, Palmer, Amy E

“…A look at how metal ions are measured in living systems via fluorescent sensors is offered, as is an overview of fluorescence imaging and sensor design. Metals…”
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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases by Lauinger, Linda, Li, Jing, Shostak, Anton, Cemel, Ibrahim Avi, Ha, Nati, Zhang, Yaru, Merkl, Philipp E, Obermeyer, Simon, Stankovic-Valentin, Nicolas, Schafmeier, Tobias, Wever, Walter J, Bowers, Albert A, Carter, Kyle P, Palmer, Amy E, Tschochner, Herbert, Melchior, Frauke, Deshaies, Raymond J, Brunner, Michael, Diernfellner, Axel

“…The bicyclic disulfide–containing compound thiolutin has broad antimicrobial activity and targets the essential proteasomal deubiquitinase Rpn11 and other…”
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Metallobiology: zinc differently by Carter, Kyle P, Palmer, Amy E

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Stereocontrolled Synthesis of 1,3-Diols from Enones: Cooperative Lewis Base-Mediated Intramolecular Carbonyl Hydrosilylations by Medina, Casey, Carter, Kyle P, Miller, Michael, Clark, Timothy B, O’Neil, Gregory W

“…A streamlined synthesis of β-hydroxy ketone substrates has been developed to further investigate a recently discovered cooperative Lewis base-mediated…”
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1380 Non-clinical results and design of first-in-human study for GIGA-564, a third-generation anti-CTLA-4 monoclonal antibody by Redman, Jason M, Poon, Vincent, Niedecken, Ariel, Chiang, Yao, Deng, Rong, Stadtmiller, Kacy, Asensio, Michael A, Lansita, Janice, Carter, Kyle P, Wagner, Ellen K, Garmey, Edward, Millward, Carl, Gulley, James L, Stone, Erica L

“…BackgroundAnti-CTLA-4 antibodies, such as ipilimumab, were among the first immuno-oncology agents to provide significantly improved outcomes for patients…”
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A masked-alkene metathesis-based synthesis of isopulo’upone by Carter, Kyle P., Moser, Daniel J., Storvick, Jennifer M., O’Neil, Gregory W.

“…A metathesis-based formal synthesis of (±)-isopulo’upone has been completed featuring a masked olefin metathesis/elimination sequence followed by an…”
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Direct Conversion of β-Hydroxyketones to Cyclic Disiloxanes by O’Neil, Gregory W, Miller, Michael M, Carter, Kyle P

“…β-Hydroxyketones can be directly converted to cyclic disiloxanes using diphenylchlorosilane in the presence of imidazole and an amine base. The reaction is…”
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Zinc differently by Carter, Kyle P., Palmer, Amy E.

“…An extracellular ejection of zinc, known as a zinc spark, is triggered by the fertilization of a mammalian egg; however, the origin of this zinc was not clear…”
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Discovery of a ZIP7 inhibitor from a Notch pathway screen by Nolin, Erin, Gans, Sara, Llamas, Luis, Bandyopadhyay, Somnath, Brittain, Scott M., Bernasconi-Elias, Paula, Carter, Kyle P., Loureiro, Joseph J., Thomas, Jason R., Schirle, Markus, Yang, Yi, Guo, Ning, Roma, Guglielmo, Schuierer, Sven, Beibel, Martin, Lindeman, Alicia, Sigoillot, Frederic, Chen, Amy, Xie, Kevin X., Ho, Samuel, Reece-Hoyes, John, Weihofen, Wilhelm A., Tyskiewicz, Kayla, Hoepfner, Dominic, McDonald, Richard I., Guthrie, Nicolette, Dogra, Abhishek, Guo, Haibing, Shao, Jian, Ding, Jian, Canham, Stephen M., Boynton, Geoff, George, Elizabeth L., Kang, Zhao B., Antczak, Christophe, Porter, Jeffery A., Wallace, Owen, Tallarico, John A., Palmer, Amy E., Jenkins, Jeremy L., Jain, Rishi K., Bushell, Simon M., Fryer, Christy J.

“…The identification of activating mutations in NOTCH1 in 50% of T cell acute lymphoblastic leukemia has generated interest in elucidating how these mutations…”
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GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2 by Mizrahi, Rena A, Lin, Wendy Y, Gras, Ashley, Niedecken, Ariel R, Wagner, Ellen K, Keating, Sheila M, Ikon, Nikita, Manickam, Vishal A, Asensio, Michael A, Leong, Jackson, Medina-Cucurella, Angelica V, Benzie, Emily, Carter, Kyle P, Chiang, Yao, Edgar, Robert C, Leong, Renee, Lim, Yoong Wearn, Simons, Jan Fredrik, Spindler, Matthew J, Stadtmiller, Kacy, Wayham, Nicholas, Büscher, Dirk, Terencio, Jose Vicente, Germanio, Clara Di, Chamow, Steven M, Olson, Charles, Pino, Paula A, Park, Jun-Gyu, Hicks, Amberlee, Ye, Chengjin, Garcia-Vilanova, Andreu, Martinez-Sobrido, Luis, Torrelles, Jordi B, Johnson, David S, Adler, Adam S

“…Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating…”
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Engineering and Evaluating Fluorescent Tools for Endoplasmic Reticulum Zinc by Carter, Kyle P

“…Zinc (Zn2+) is an essential micronutrient for human health. However, excess Zn2+ is toxic and Zn2+ deficiency can be fatal, so the concentration of this ion…”
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Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR by Simons, Jan Fredrik, Lim, Yoong Wearn, Carter, Kyle P., Wagner, Ellen K., Wayham, Nicholas, Adler, Adam S., Johnson, David S.

“…In vitro affinity maturation of therapeutic monoclonal antibodies is commonly applied to achieve desired properties, such as improved binding kinetics and…”
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The Contribution of Frank Moore Cross to Northwest Semitic Epigraphy by McCarter, P. Kyle

“…Frank Moore Cross was a transformational figure in Northwest Semitic epigraphy. His work on the Jewish Scripts of the post-exilic period, beginning in the…”
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