The association between narcolepsy during pregnancy and maternal-fetal risk factors/outcomes

The association between narcolepsy during pregnancy and maternal-fetal risk factors/outcomes

Objective We sought to determine whether narcolepsy in pregnancy is associated with adverse maternal-fetal outcomes. Material and Methods A retrospective, cross-sectional analysis was performed using the nationwide inpatient sample (NIS) for the period 2008-2017. The primary exposure was narcolepsy...

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Bibliographic Details
Published in:Sleep science (São Paulo, SP ) Vol. 15; no. 3; pp. 297 - 304
Main Authors: Wilson, Annise, Dongarwar, Deepa, Carter, Krystal, Marroquin, Maricarmen, Salihu, Hamisu M
Format: Journal Article
Language:English
Published: Brazilian Association of Sleep and Latin American Federation of Sleep 01-01-2022
Thieme Revinter Publicações Ltda
Subjects:
cataplexy
delivery
hospitalization
morbidity
narcolepsy
obstetric
Original
pregnancy
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Summary:Objective We sought to determine whether narcolepsy in pregnancy is associated with adverse maternal-fetal outcomes. Material and Methods A retrospective, cross-sectional analysis was performed using the nationwide inpatient sample (NIS) for the period 2008-2017. The primary exposure was narcolepsy with cataplexy, narcolepsy type 1 (NT1), and without cataplexy, narcolepsy type 2 (NT2), and the endpoints were a composite of maternal-fetal outcomes or risk factors. Results A total of 7,742 hospitalizations among pregnant women with narcolepsy were identified (prevalence = 17.6 per 100,000), of which 6,769 (88%) were diagnosed with NT2. Statistically significant positive associations were found between narcolepsy and the following conditions: obesity (odds ratio (OR): 2.99, confidence interval (CI): 2.4-3.74), anemia (OR=1.41, CI: 1.13-1.77), pre-pregnancy hypertension (OR=1.93, CI: 1.37-2.7), pre-pregnancy diabetes (OR=1.7, CI: 1.08-2.84), and gestational hypertension (OR=1.58, CI: 1.13-2.20) in the ICD-9 group. Similar findings were noted in the ICD-10 group with the exception of gestational hypertension, gestational diabetes, and anemia. Conclusion Given these important findings, we propose a global approach of screening for narcolepsy among women of reproductive age with pre-existing risk factors prior to conception to minimize pregnancy complications.
ISSN:1984-0659
1984-0063
DOI:10.5935/1984-0063.20220054