Search Results - "Carter, Edward P"

Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861 by Pedrosa, Ana-Rita, Bodrug, Natalia, Gomez-Escudero, Jesus, Carter, Edward P, Reynolds, Louise E, Georgiou, Paraskivi Natalia, Fernandez, Isabelle, Lees, Delphine M, Kostourou, Vassiliki, Alexopoulou, Annika N, Batista, Silvia, Tavora, Bernardo, Serrels, Bryan, Parsons, Maddy, Iskratsch, Thomas, Hodivala-Dilke, Kairbaan M

“…Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861…”
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Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion by Murray, Elizabeth R., Menezes, Shinelle, Henry, Jack C., Williams, Josie L., Alba-Castellón, Lorena, Baskaran, Priththivika, Quétier, Ivan, Desai, Ami, Marshall, Jacqueline J.T., Rosewell, Ian, Tatari, Marianthi, Rajeeve, Vinothini, Khan, Faraz, Wang, Jun, Kotantaki, Panoraia, Tyler, Eleanor J., Singh, Namrata, Reader, Claire S., Carter, Edward P., Hodivala-Dilke, Kairbaan, Grose, Richard P., Kocher, Hemant M., Gavara, Nuria, Pearce, Oliver, Cutillas, Pedro, Marshall, John F., Cameron, Angus J.M.

“…In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs)…”
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HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via PHLDA1 Induction by Clayton, Natasha S, Carter, Edward P, Fearon, Abbie E, Heward, James A, Rodríguez Fernández, Lucía, Boughetane, Lina, Wilkes, Edmund H, Cutillas, Pedro R, Grose, Richard P

“…The downregulation of Pleckstrin Homology-Like Domain family A member 1 (PHLDA1) expression mediates resistance to targeted therapies in receptor tyrosine…”
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A 3D in vitro model of the human breast duct: a method to unravel myoepithelial-luminal interactions in the progression of breast cancer by Carter, Edward P, Gopsill, James A, Gomm, Jennifer J, Jones, J Louise, Grose, Richard P

“…3D modelling fulfils a critical role in research, allowing for complex cell behaviour and interactions to be studied in physiomimetic conditions. With tissue…”
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Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion by Tomas Bort, Elena, Joseph, Megan D, Wang, Qiaoying, Carter, Edward P, Roth, Nicolas J, Gibson, Jessica, Samadi, Ariana, Kocher, Hemant M, Simoncelli, Sabrina, McCormick, Peter J, Grose, Richard P

“…Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the…”
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Low HER2 expression in normal breast epithelium enables dedifferentiation and malignant transformation via chromatin opening by Hayat, Ateequllah, Carter, Edward P, King, Hamish W, Ors, Aysegul, Doe, Aaron, Teijeiro, Saul A, Charrot, Sarah, Godinho, Susana, Cutillas, Pedro, Mohammed, Hisham, Grose, Richard P, Ficz, Gabriella

“…Overexpression of the HER2 protein in breast cancer patients is a predictor of poor prognosis and resistance to therapies. We used an inducible breast cancer…”
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PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer by Fearon, Abbie E., Carter, Edward P., Clayton, Natasha S., Wilkes, Edmund H., Baker, Ann-Marie, Kapitonova, Ekaterina, Bakhouche, Bakhouche A., Tanner, Yasmine, Wang, Jun, Gadaleta, Emanuela, Chelala, Claude, Moore, Kate M., Marshall, John F., Chupin, Juliette, Schmid, Peter, Jones, J. Louise, Lockley, Michelle, Cutillas, Pedro R., Grose, Richard P.

“…Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine…”
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Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer by Carter, Edward P, Coetzee, Abigail S, Tomas Bort, Elena, Wang, Qiaoying, Kocher, Hemant M, Grose, Richard P

“…Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis with a 5 year survival rate of less than 8%, and is predicted to become the second leading cause…”
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TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression by Gibson, Shayin V., Tomas Bort, Elena, Rodríguez-Fernández, Lucía, Allen, Michael D., Gomm, Jennifer J., Goulding, Iain, auf dem Keller, Ulrich, Agnoletto, Andrea, Brisken, Cathrin, Peck, Barrie, Cameron, Angus J., Marshall, John F., Jones, J. Louise, Carter, Edward P., Grose, Richard P.

“…Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting…”
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Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction by Carter, Edward P, Fearon, Abbie E, Grose, Richard P

“…Highlights • We review the latest data on cellular fibroblast growth factor receptor (FGFR) signalling mechanisms and pathways. • We highlight key roles of…”
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Interrogating the Impact of Protease Activity on Tumor Progression Using 3D Spheroid Models by Gibson, Shayin V, Carter, Edward P, Grose, Richard P

“…Cancers have a complex relationship with the surrounding environment that regulates everything from progression to response to treatment. Cell-cell and…”
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Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption by Adams, Sophie D., Csere, Judit, D’angelo, Gisela, Carter, Edward P., Romao, Maryse, Arnandis, Teresa, Dodel, Martin, Kocher, Hemant M., Grose, Richard, Raposo, Graça, Mardakheh, Faraz, Godinho, Susana A.

“…Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs),…”
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Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1 by Coetzee, Abigail S., Carter, Edward P., Rodríguez-Fernández, Lucía, Heward, James, Wang, Qiaoying, Karim, Saadia A., Boughetane, Lina, Milton, Christopher, Uyulur, Firat, Morton, Jennifer P., Kocher, Hemant M., Grose, Richard P.

“…Pancreatic stellate cells (PSCs) are key to the treatment-refractory desmoplastic phenotype of pancreatic ductal adenocarcinoma (PDAC) and have received…”
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ADAMTS3 restricts cancer invasion in models of early breast cancer progression through enhanced fibronectin degradation by Gibson, Shayin V., Madzharova, Elizabeta, Tan, Amandine C., Allen, Michael D., Keller, Ulrich auf dem, Louise Jones, J., Carter, Edward P., Grose, Richard P.

“…•Metzincins display both pro- and anti-invasive effects in breast cancer.•Loss of myoepithelial ADAMTS3 expression drives invasion.•Degradomic analysis…”
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Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function by Carter, Edward P, Yoneten, Kubra K, Gavara, Nuria, Tyler, Eleanor J, Gauthier, Valentine, Murray, Elizabeth R, Dijke, Peter, Cameron, Angus J, Pearce, Oliver, Grose, Richard P

“…Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drives…”
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Tumour microenvironment 3D-modelling: simplicity to complexity and back again by Carter, Edward P, Roozitalab, Reza, Gibson, Shayin V, Grose, Richard P

“…Tumours are surrounded by a host of noncancerous cells that fulfil both supportive and suppressive roles within the tumour microenvironment (TME). The drive to…”
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Correction: Nuclear FGFR1 promotes pancreatic stellate cell-driven invasion through up-regulation of Neuregulin 1 by Coetzee, Abigail S., Carter, Edward P., Rodríguez-Fernández, Lucía, Heward, James, Wang, Qiaoying, Karim, Saadia A., Boughetane, Lina, Milton, Christopher, Uyulur, Firat, Morton, Jennifer P., Kocher, Hemant M., Grose, Richard P.

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Everybody needs good neighbours: the progressive DCIS microenvironment by Gibson, Shayin V, Roozitalab, Reza M, Allen, Michael D, Jones, J Louise, Carter, Edward P, Grose, Richard P

“…Ductal carcinoma in situ (DCIS) is a pre-invasive form of breast cancer where neoplastic luminal cells are confined to the ductal tree. While as many as 70% of…”
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HDAC Inhibition Restores Response to HER2-Targeted Therapy in Breast Cancer via IPHLDA1/I Induction by Clayton, Natasha S, Carter, Edward P, Fearon, Abbie E, Heward, James A, Rodríguez Fernández, Lucía, Boughetane, Lina, Wilkes, Edmund H, Cutillas, Pedro R, Grose, Richard P

“…The downregulation of Pleckstrin Homology-Like Domain family A member 1 (PHLDA1) expression mediates resistance to targeted therapies in receptor tyrosine…”
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Liver herniation through an occult diaphragmatic injury presenting as a solitary pulmonary nodule: Value of helical computed tomography and magnetic resonance imaging by Pomerantz, Stephen M., Shanmuganathan, K., Siegel, Eliot L., Mirvis, Stuart E., Carter, Edward P.

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