Search Results - "Carter, Alun"

A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity by Kim, Miriam Y., Jayasinghe, Reyka, Devenport, Jessica M., Ritchey, Julie K., Rettig, Michael P., O’Neal, Julie, Staser, Karl W., Kennerly, Krista M., Carter, Alun J., Gao, Feng, Lee, Byung Ha, Cooper, Matthew L., DiPersio, John F.

“…Chimeric antigen receptor (CAR) T cell therapy is routinely used to treat patients with refractory hematologic malignancies. However, a significant proportion…”
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An “off-the-shelf” CD2 universal CAR-T therapy for T-cell malignancies by Xiang, Jingyu, Devenport, Jessica M., Carter, Alun J., Staser, Karl W., Kim, Miriam Y., O’ Neal, Julie, Ritchey, Julie K., Rettig, Michael P., Gao, Feng, Rettig, Garrett, Turk, Rolf, Lee, Byung Ha, Cooper, Matthew L., DiPersio, John F.

“…T-cell malignancies are associated with frequent relapse and high morbidity, which is partly due to the lack of effective or targeted treatment options. To…”
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Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology by Whitfield, Sarah J C, Taylor, Chris, Risdall, Jane E, Griffiths, Gareth D, Jones, James T A, Williamson, E Diane, Rijpkema, Sjoerd, Saraiva, Luisa, Vessillier, Sandrine, Green, A Christopher, Carter, Alun J

“…Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds the receptors in the APC/T cell synapse and causes increased proliferation of T cells…”
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Anti-myeloma efficacy of BCMA CAR-iNKT is enhanced with a long-acting IL-7, rhIL7hyFc by O'Neal, Julie, Cooper, Matthew L., Ritchey, Julie K., Gladney, Susan, Niswonger, Jessica, Sofía González, L., Street, Emily, Haas, Gabriel J., Carter, Alun, Amayta, Parmeshwar N., Gao, Feng, Ha Lee, Byung, Choi, Donghoon, Berrien-Elliott, Melissa, Zhou, Alice, Fehniger, Todd A., Rettig, Mike P., DiPersio, John F.

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Targeting the “Rising DAMP” during a Francisella tularensis Infection by D'ELIA, Riccardo V, LAWS, Thomas R, CARTER, Alun, LUKASZEWSKI, Roman, CLARK, Graeme C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Endothelial Activation and Chemoattractant Expression are Early Processes in Isolated Blast Brain Injury by Risdall, Jane E., Carter, Alun J., Kirkman, Emrys, Watts, Sarah A., Taylor, Christopher, Menon, David K.

“…Blast injuries are an increasing problem in military conflicts and terrorist incidents. Blast-induced traumatic brain injury has risen to prominence and…”
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Mechanistic Studies of Cytokine Release Syndrome (CRS) with Roles of Interferon-Gamma (IFN-g) and Tumor Necrosis Factor Alpha (TNF-α) While Maintaining CAR-T Function in Vitro by Amatya, Parmeshwar N, Xiang, Jingyu, O'Neal, Julie, Ritchey, Julie K., Carter, Alun J, Cooper, Matthew L., DiPersio, John

“…Background: Chimeric Antigen Receptor (CAR) T cell therapy in patients with hematologic malignancies is limited by immune-related toxicities such as Cytokine…”
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Colonisation of poultry by Salmonella Enteritidis S1400 is reduced by combined administration of Lactobacillus salivarius 59 and Enterococcus faecium PXN-33 by Carter, Alun, Adams, Martin, La Ragione, Roberto M., Woodward, Martin J.

“…•An oral contact & sentinel bird models were used to evaluate Salmonella colonisation.•E. faecium PXN33 &L. salivarius 59 prevented S. Enteritidis colonisation…”
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Abstract 1127: Adarza's ZIVA multiplex protein detection platform utilizes a label-free technology to simultaneously monitor murine and human inflammation cytokines in a CAR-T model system by Schmuke, Jon J., Carter, Alun, Zhou, You, Mueller, Ernest, Cooper, Matt

“…We have used Arrayed Imaging Reflectometry (AIR™), a label-free protein microarray technology that relies on the target binding-induced perturbation of an…”
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Adarza’s ZIVA multiplex protein detection platform utilizes a label-free technology to simultaneously monitor murine and human inflammation cytokines in a CAR-T model system by Schmuke, Jon J, Mueller, Ernie, Carter, Alun, Cooper, Matt, Kabakibi, Ayman

“…We have used Arrayed Imaging Reflectometry (AIR™), a label-free protein microarray technology that relies on the target binding-induced perturbation of an…”
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Adarza’s ZIVA multiplex protein detection platform demonstrates flexibility with custom targets for monitoring both inflammation and anti-drug antibody response by Schmuke, Jon J, Pillers, Michelle, Mueller, Ernie, Cooper, Matt, Carter, Alun, Kabakibi, Ayman

“…We have used Arrayed Imaging Reflectometry (AIR™), a label-free protein microarray technology that relies on the target binding-induced perturbation of an…”
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The Dual PI3Kdg Inhibitor Duvelisib Potently Inhibits Cytokine Release Syndrome (CRS) While Maintaining CAR-T Function by Amatya, Parmeshwar N., Jayasinghe, Reyka G., Carter, Alun J., Cooper, Matthew L., Pachter, Jonathan A., DiPersio, John F., Ritchey, Julie K.

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Identification of Small Molecule Kinase Inhibitors That Potently and Reversibly Block Chimeric Antigen Receptor T Cell Proliferation and Cytotoxicity by Amatya, Parmeshwar, Cooper, Matthew L., Carter, Alun J, DiPersio, John F.

“…Introduction: Despite remarkable clinical efficacy, CAR-T therapy has been limited by life threatening toxicities in over 30% of patients.1, 2 Toxicities…”
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An “Off-the-Shelf” CD2 Universal CAR-T Therapy Combined with a Long-Acting IL-7 for T-Cell Malignancies by Xiang, Jingyu, Devenport, Jessica, Carter, Alun J, Staser, Karl, Rettig, Michael P., Kim, Miriam Y, O'Neal, Julie, Ritchey, Julie K., Gao, Feng, Rettig, Garrett, Turk, Rolf, Wolfarth, Alexandra, Lee, Byung Ha, Cooper, Matthew L., DiPersio, John F.

“…INTRODUCTION: T-cell malignancies are associated with frequent relapse and high morbidity in children and adults, partly due to the lack of effective or…”
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The Dual PI3Kδγ Inhibitor Duvelisib Potently Inhibits IL-6 Production and Cytokine Release Syndrome (CRS) While Maintaining CAR-T Function in Vitro and In Vivo by Amatya, Parmeshwar N, Carter, Alun J, Ritchey, Julie K, Niswonger, Jessica, Cooper, Matthew L, Pachter, Jonathan A, DiPersio, John F.

“…Despite remarkable clinical efficacy, CAR-T therapy has been limited by life-threatening toxicities in over 30% of patients (Maude, NEJM 2014 and Davila,…”
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9. The dual PI3K inhibitor duvelisib potently inhibits cytokine release syndrome while maintaining CAR-T function by Amatya, Parmeshwar, Carter, Alun, Ritchey, Julie, Jayasinghe, Reyka, Cooper, Matthew, Pachter, Jonathan, Dipersio, John

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WU-NK-101, an enhanced memory natural killer (NK) cell therapy, with cetuximab (Ctx) for the treatment of advanced colorectal cancer (CRC) by Muth, John, Leedom, Tom, Hamil, Alexander, Luukkonen, Lena, Tumala, Brunda, Carter, Alun, Magee, Kristann, Comune Pennacchi, Paula, Primo, Daniel, Kiebish, Michael A., Boocock, David, Vadakekolathu, Jayakumar, Petit, Vincent, Baughman, Jan E., Bhatnagar, Nupur, Cooper, Matthew, Rutella, Sergio, Berrien-Elliot, Melissa, Davidson-Moncada, Jan, Fehniger, Todd A.

“…170 Background: CRC is the 4 th leading cause of global cancer-related deaths, and novel therapeutic strategies for advanced CRC are urgently needed. Adoptive…”
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Putative Predictors of Response to WU-NK-101, an Allogeneic, Enhanced Memory (ML) Natural Killer (NK) Cell Therapy Product, for Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) by Rutella, Sergio, Cashen, Amanda F., Muth, John, Mathyer, Mary Elizabeth, Carter, Alun James, Tumala, Brunda, Arthur, Laura, Magee, Kristann, Comune Pennacchi, Paula, Gorrochategui, Julian, Petit, Vincent, Primo, Daniel, Blanchard, Dominique, Kiebish, Michael, Bhatnagar, Nupur, Boocock, David, Vadakekolathu, Jayakumar, Cooper, Matthew L, Berrien-Elliott, Melissa M., Davidson-Moncada, Jan K, Fehniger, Todd A.

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Abstract 1765: A humanized anti-CD47 monoclonal antibody that directly kills human tumor cells and has additional unique functional characteristics by Puro, Robyn, Liu, Katherine, Capoccia, Benjamin, Donio, Michael, Hiebsch, Ronald, Bouchlaka, Myriam, Carter, Alun, Manning, Pamela, Crowley, Kathleen, Karr, Robert

“…CD47 is a cell surface glycoprotein that interacts with signal regulatory protein alpha (SIRPα) on macrophages and dendritic cells triggering a “don't eat me”…”
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Therapeutic Potential of AO-176, a Next Generation Humanized CD47 Antibody, for Hematologic Malignancies by Wilson, W. Casey, Bouchlaka, Myriam N, Capoccia, Ben J, Hiebsch, Ronald R, Donio, Michael J, Puro, Robyn J, Carter, Alun J, Chakraborty, Prabir, Manning, Pamela T, Karr, Robert W, Sung, Vicki, Pereira, Daniel S

“…Inhibitors of adaptive immune checkpoints have shown promise as cancer treatments. CD47 is an innate immune checkpoint receptor broadly expressed on normal…”
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