Search Results - "Carter, Alice R"

Investigating effect modification between childhood maltreatment and genetic risk for cardiovascular disease in the UK Biobank by Urquijo, Helena, Soares, Ana Gonçalves, Fraser, Abigail, Howe, Laura D, Carter, Alice R

“…Cardiovascular disease (CVD) is influenced by genetic and environmental factors. Childhood maltreatment is associated with CVD and may modify genetic…”
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Educational inequality in multimorbidity: causality and causal pathways. A mendelian randomisation study in UK Biobank by North, Teri-Louise, Harrison, Sean, Bishop, Deborah C, Wootton, Robyn E, Carter, Alice R, Richardson, Tom G, Payne, Rupert A, Salisbury, Chris, Howe, Laura D

“…Multimorbidity, typically defined as having two or more long-term health conditions, is associated with reduced wellbeing and life expectancy. Understanding…”
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Time-sensitive testing pressures and COVID-19 outcomes: are socioeconomic inequalities over the first year of the pandemic explained by selection bias? by Carter, Alice R, Clayton, Gemma L, Borges, M Carolina, Howe, Laura D, Hughes, Rachael A, Smith, George Davey, Lawlor, Deborah A, Tilling, Kate, Griffith, Gareth J

“…There are many ways in which selection bias might impact COVID-19 research. Here we focus on selection for receiving a polymerase-chain-reaction (PCR)…”
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Accounting for bias due to outcome data missing not at random: comparison and illustration of two approaches to probabilistic bias analysis: a simulation study by Kawabata, Emily, Major-Smith, Daniel, Clayton, Gemma L., Shapland, Chin Yang, Morris, Tim P., Carter, Alice R., Fernández-Sanlés, Alba, Borges, Maria Carolina, Tilling, Kate, Griffith, Gareth J., Millard, Louise A. C., Smith, George Davey, Lawlor, Deborah A., Hughes, Rachael A.

“…Abstract Background Bias from data missing not at random (MNAR) is a persistent concern in health-related research. A bias analysis quantitatively assesses how…”
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Why caution should be applied when interpreting and promoting findings from Mendelian randomisation studies by Carter, Alice R, Fraser, Abigail, Howe, Laura D, Harris, Sian, Hughes, Amanda

“…After correction for multiple testing, the authors reported a small but statistically significant result for the effect of diastolic blood pressure (DBP) on…”
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Mental Health as a Mediator of the Association Between Educational Inequality and Cardiovascular Disease: A Mendelian Randomization Study by Jones, Daniel P, Wootton, Robyn E, Gill, Dipender, Carter, Alice R, Gunnell, David, Munafò, Marcus R, Sallis, Hannah M

“…Background Education is inversely associated with cardiovascular disease (CVD). Several mediators of this have been established; however, a proportion of the…”
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Role of the Metabolic Profile in Mediating the Relationship Between Body Mass Index and Left Ventricular Mass in Adolescents: Analysis of a Prospective Cohort Study by Carter, Alice R, Santos Ferreira, Diana L, Taylor, Amy E, Lawlor, Deborah A, Davey Smith, George, Sattar, Naveed, Chaturvedi, Nishi, Hughes, Alun D, Howe, Laura D

“…Background We aimed to quantify the role of the plasma metabolic profile in explaining the effect of adiposity on cardiac structure. Methods and Results Body…”
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Mendelian randomisation for mediation analysis: current methods and challenges for implementation by Carter, Alice R., Sanderson, Eleanor, Hammerton, Gemma, Richmond, Rebecca C., Davey Smith, George, Heron, Jon, Taylor, Amy E., Davies, Neil M., Howe, Laura D.

“…Mediation analysis seeks to explain the pathway(s) through which an exposure affects an outcome. Traditional, non-instrumental variable methods for mediation…”
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Correct illustration of assumptions in Mendelian randomization by Carter, Alice R, Anderson, Emma L

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The impact of education inequality on rheumatoid arthritis risk is mediated by smoking and body mass index: Mendelian randomization study by Zhao, Sizheng Steven, Holmes, Michael V, Zheng, Jie, Sanderson, Eleanor, Carter, Alice R

“…Abstract Objective To estimate the causal relationship between educational attainment—as a proxy for socioeconomic inequality—and risk of RA, and quantify the…”
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Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study by Carter, Alice R, Gill, Dipender, Davies, Neil M, Taylor, Amy E, Tillmann, Taavi, Vaucher, Julien, Wootton, Robyn E, Munafò, Marcus R, Hemani, Gibran, Malik, Rainer, Seshadri, Sudha, Woo, Daniel, Burgess, Stephen, Davey Smith, George, Holmes, Michael V, Tzoulaki, Ioanna, Howe, Laura D, Dehghan, Abbas

“…AbstractObjectivesTo investigate the role of body mass index (BMI), systolic blood pressure, and smoking behaviour in explaining the effect of education on the…”
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Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis by Gill, Dipender, Zuber, Verena, Dawson, Jesse, Pearson-Stuttard, Jonathan, Carter, Alice R., Sanderson, Eleanor, Karhunen, Ville, Levin, Michael G., Wootton, Robyn E., Klarin, Derek, Tsao, Philip S., Tsilidis, Konstantinos K., Damrauer, Scott M., Burgess, Stephen, Elliott, Paul

“…Background Higher body mass index (BMI) and waist-to-hip ratio (WHR) increase the risk of cardiovascular disease, but the extent to which this is mediated by…”
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Educational attainment as a modifier for the effect of polygenic scores for cardiovascular risk factors: cross-sectional and prospective analysis of UK Biobank by Carter, Alice R, Harrison, Sean, Gill, Dipender, Davey Smith, George, Taylor, Amy E, Howe, Laura D, Davies, Neil M

“…Abstract Background Understanding the interplay between educational attainment and genetic predictors of cardiovascular risk may improve our understanding of…”
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A framework for assessing selection and misclassification bias in mendelian randomisation studies: an illustrative example between body mass index and covid-19 by Clayton, Gemma L, Gonçalves, Ana, Soares, Goulding, Neil, Borges, Maria Carolina, Holmes, Michael V, Davey, George, Smith, Tilling, Kate, Lawlor, Deborah A, Carter, Alice R

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Exploring the impact of selection bias in observational studies of COVID-19: a simulation study by Millard, Louise A C, Fernández-Sanlés, Alba, Carter, Alice R, Hughes, Rachael A, Tilling, Kate, Morris, Tim P, Major-Smith, Daniel, Griffith, Gareth J, Clayton, Gemma L, Kawabata, Emily, Davey Smith, George, Lawlor, Deborah A, Borges, Maria Carolina

“…Non-random selection of analytic subsamples could introduce selection bias in observational studies. We explored the potential presence and impact of selection…”
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Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes by Walker, Venexia M., Vujkovic, Marijana, Carter, Alice R., Davies, Neil M., Udler, Miriam S., Levin, Michael G., Davey Smith, George, Voight, Benjamin F., Gaunt, Tom R., Damrauer, Scott M.

“…Aims/hypothesis Type 2 diabetes and atherosclerotic CVD share many risk factors. This study aimed to systematically assess a broad range of continuous traits…”
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Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses by Crick, Daisy C.P., Sanderson, Eleanor, Jones, Hannah, Goulding, Neil, Borges, Maria Carolina, Clayton, Gemma, Carter, Alice R., Halligan, Sarah, Lawlor, Deborah A., Khandaker, Golam M., Fraser, Abigail

“…Inflammation is associated with depression, but causality remains unclear. We investigated potential causality and direction of effect between inflammation and…”
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Using Genetic Instruments to Estimate Interactions in Mendelian Randomization Studies by North, Teri-Louise, Davies, Neil M, Harrison, Sean, Carter, Alice R, Hemani, Gibran, Sanderson, Eleanor, Tilling, Kate, Howe, Laura D

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Metabolic profiles of socio-economic position: a multi-cohort analysis by Robinson, Oliver, Carter, Alice R, Ala-Korpela, Mika, Casas, Juan P, Chaturvedi, Nishi, Engmann, Jorgen, Howe, Laura D, Hughes, Alun D, Järvelin, Marjo-Riitta, Kähönen, Mika, Karhunen, Ville, Kuh, Diana, Shah, Tina, Ben-Shlomo, Yoav, Sofat, Reecha, Lau, Chung-Ho E, Lehtimäki, Terho, Menon, Usha, Raitakari, Olli, Ryan, Andy, Providencia, Rui, Smith, Stephanie, Taylor, Julie, Tillin, Therese, Viikari, Jorma, Wong, Andrew, Hingorani, Aroon D, Kivimäki, Mika, Vineis, Paolo

“…Abstract Background Low socio-economic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear…”
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Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer by Wade, Kaitlin H., Yarmolinsky, James, Giovannucci, Edward, Lewis, Sarah J., Millwood, Iona Y., Munafò, Marcus R., Meddens, Fleur, Burrows, Kimberley, Bell, Joshua A., Davies, Neil M., Mariosa, Daniela, Kanerva, Noora, Vincent, Emma E., Smith-Byrne, Karl, Guida, Florence, Gunter, Marc J., Sanderson, Eleanor, Dudbridge, Frank, Burgess, Stephen, Cornelis, Marilyn C., Richardson, Tom G., Borges, Maria Carolina, Bowden, Jack, Hemani, Gibran, Cho, Yoonsu, Spiller, Wes, Richmond, Rebecca C., Carter, Alice R., Langdon, Ryan, Lawlor, Deborah A., Walters, Robin G., Vimaleswaran, Karani Santhanakrishnan, Anderson, Annie, Sandu, Meda R., Tilling, Kate, Davey Smith, George, Martin, Richard M., Relton, Caroline L.

“…Dietary factors are assumed to play an important role in cancer risk, apparent in consensus recommendations for cancer prevention that promote nutritional…”
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