Search Results - "Carswell, Hilary V O"

Placenta-Derived Cells for Acute Brain Injury by Pischiutta, Francesca, Sammali, Eliana, Parolini, Ornella, Carswell, Hilary V. O., Zanier, Elisa R.

“…Acute brain injury resulting from ischemic/hemorrhagic or traumatic damage is one of the leading causes of mortality and disability worldwide and is a…”
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Silk Hydrogel Substrate Stress Relaxation Primes Mesenchymal Stem Cell Behavior in 2D by Phuagkhaopong, Suttinee, Mendes, Luís, Müller, Katrin, Wobus, Manja, Bornhäuser, Martin, Carswell, Hilary V. O, Duarte, Iola F, Seib, F. Philipp

“…Tissue-mimetic silk hydrogels are being explored for diverse healthcare applications, including stem cell delivery. However, the impact of stress relaxation of…”
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Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome by Patkar, Shalmali, Uwanogho, Dafe, Modo, Michel, Tate, Rothwelle J., Plevin, Robin, Carswell, Hilary V. O.

“…Dax-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital region on X-chromosome gene 1) blocks 17β-estradiol biosynthesis and its knockdown would be…”
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Complexities of oestrogen in stroke by Carswell, Hilary V O, Macrae, I Mhairi, Farr, Tracy D

“…Evidence exists for the potential protective effects of circulating ovarian hormones in stroke, and oestrogen reduces brain damage in animal ischaemia models…”
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Genetic Aspects of Stroke: Human and Experimental Studies by Carr, Fiona J., McBride, Martin W., Carswell, Hilary V. O., Graham, Delyth, Strahorn, Pamela, Clark, James S., Charchar, Fadi J., Dominiczak, Anna F.

“…As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. Risk factors can be identified and…”
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Estrogen receptor beta agonist diarylpropiolnitrile (DPN) does not mediate neuroprotection in a rat model of permanent focal ischemia by Farr, Tracy D, Carswell, Hilary V.O, Gsell, Willy, Macrae, I. Mhairi

“…Abstract Selective estrogen receptor (ER) agonists can indicate which receptor subtypes are implicated in neuroprotection. This study investigated the…”
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Mast Cells Promote Blood Brain Barrier Breakdown and Neutrophil Infiltration in a Mouse Model of Focal Cerebral Ischemia by McKittrick, Craig M, Lawrence, Catherine E, Carswell, Hilary V O

“…Blood brain barrier (BBB) breakdown and neuroinflammation are key events in ischemic stroke morbidity and mortality. The present study investigated the effects…”
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Conditionally immortalised neural stem cells promote functional recovery and brain plasticity after transient focal cerebral ischaemia in mice by Patkar, Shalmali, Tate, Rothwelle, Modo, Michel, Plevin, Robin, Carswell, Hilary V O

“…Cell therapy has enormous potential to restore neurological function after stroke. The present study investigated effects of conditionally immortalised neural…”
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In Vivo Evaluation of Engineered Self-Assembling Silk Fibroin Hydrogels after Intracerebral Injection in a Rat Stroke Model by Gorenkova, Natalia, Osama, Ibrahim, Seib, F. Philipp, Carswell, Hilary V.O

“…Targeting the brain cavity formed by an ischemic stroke is appealing for many regenerative treatment strategies but requires a robust delivery technology. We…”
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Detrimental effects of 2-arachidonoylglycerol on whole blood platelet aggregation and on cerebral blood flow after a focal ischemic insult in rats by Shearer, Jennifer A, Coker, Susan J, Carswell, Hilary V O

“…2-Arachidonoylglycerol (2-AG) is a major modulator of blood flow and platelet aggregation and a potential neuroprotectant. The present study investigated, for…”
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Watermaze Performance after Middle Cerebral Artery Occlusion in the Rat: The Role of Sensorimotor versus Memory Impairments by Bingham, Deborah, Martin, Stephen J, Macrae, I Mhairi, Carswell, Hilary V O

“…In rodent stroke models, investigation of deficits in spatial memory using the Morris watermaze may be confounded by coexisting sensory or motor impairments…”
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Estrogen Treatment Enhances Nitric Oxide Bioavailability in Normotensive but not Hypertensive Rats by Hamilton, Carlene A., Groves, Samantha, Carswell, Hilary V.O., Brosnan, M. Julia, Graham, Delyth, Dominiczak, Anna F.

“…The effects of estrogen on endothelial function remain controversial. Endothelial function is perturbed in hypertension. We aimed to determine whether…”
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Towards clinical translation of ‘second-generation’ regenerative stroke therapies: hydrogels as game changers? by Totten, John D., Alhadrami, Hani A., Jiffri, Essam H., McMullen, Calum J., Seib, F. Philipp, Carswell, Hilary V.O.

“…Stroke is an unmet clinical need with a paucity of treatments, at least in part because chronic stroke pathologies are prohibitive to ‘first-generation’ stem…”
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Genetic and Gender Influences on Sensitivity to Focal Cerebral Ischemia in the Stroke-Prone Spontaneously Hypertensive Rat by Carswell, Hilary V.O, Anderson, Niall H, Clark, James S, Graham, Delyth, Jeffs, Baxter, Dominiczak, Anna F, Macrae, I. Mhairi

“…We have investigated genetic transmission of increased sensitivity to focal cerebral ischemia and the influence of gender in the stroke-prone spontaneously…”
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The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) by Percie du Sert, Nathalie, Alfieri, Alessio, Allan, Stuart M, Carswell, Hilary VO, Deuchar, Graeme A, Farr, Tracy D, Flecknell, Paul, Gallagher, Lindsay, Gibson, Claire L, Haley, Michael J, Macleod, Malcolm R, McColl, Barry W, McCabe, Christopher, Morancho, Anna, Moon, Lawrence DF, O’Neill, Michael J, Pérez de Puig, Isabel, Planas, Anna, Ragan, C Ian, Rosell, Anna, Roy, Lisa A, Ryder, Kathryn O, Simats, Alba, Sena, Emily S, Sutherland, Brad A, Tricklebank, Mark D, Trueman, Rebecca C, Whitfield, Lucy, Wong, Raymond, Macrae, I Mhairi

“…Most in vivo models of ischaemic stroke target the middle cerebral artery and a spectrum of stroke severities, from mild to substantial, can be achieved. This…”
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17 beta -Estradiol treatment following permanent focal ischemia does not influence recovery of sensorimotor function by Farr, Tracy D, Carswell, Hilary V O, Gallagher, Lindsay, Condon, Barrie, Fagan, Andrew J, Mullin, Jim, MacRae, I Mhairi

“…The development of therapy to aid poststroke recovery is essential. The female hormone 17 beta -estradiol has been shown to promote synaptogenesis; the purpose…”
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Characterization of the Microglial Response to Cerebral Ischemia in the Stroke-Prone Spontaneously Hypertensive Rat by Marks, Louise, Carswell, Hilary V.O, Peters, Elaine E, Graham, David I, Patterson, James, Dominiczak, Anna F, Macrae, I Mhairi

“…Stroke-prone spontaneously hypertensive rats (SHRSP) sustain more ischemic damage after middle cerebral artery occlusion than do their reference strain, the…”
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Investigation of Estrogen Status and Increased Stroke Sensitivity on Cerebral Blood Flow After a Focal Ischemic Insult by Carswell, Hilary V. O., Anderson, Niall H., Morton, James J., McCulloch, James, Dominiczak, Anna F., Macrae, I. Mhairi

“…Recently the authors have shown that female stroke-prone spontaneously hypertensive rats (SHRSPs) in proestrus (high endogenous estrogen), sustain more than…”
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Effects of 17β-oestradiol on cerebral ischaemic damage and lipid peroxidation by Gordon, Kirsty B., Macrae, I. Mhairi, Carswell, Hilary V.O.

“…Numerous studies demonstrate oestrogen's neuroprotective effect in stroke models, although the mechanisms are unclear. Since oestrogen is an antioxidant, we…”
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Differential effects of oestrogen in models of permanent and transient focal cerebral ischaemia by Gordon, Kirsty B, Macrae, I Mhairi, Carswell, Hilary V O

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