Search Results - "Carstens, Russ P"

Functional roles of alternative splicing factors in human disease by Cieply, Benjamin, Carstens, Russ P.

“…Alternative splicing (AS) is an important mechanism used to generate greater transcriptomic and proteomic diversity from a finite genome. Nearly all human gene…”
Get full text

Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT) by Warzecha, Claude C, Carstens, Russ P

“…Abstract The epithelial-to-mesenchymal transition (EMT) is an important developmental process that is also implicated in disease pathophysiology, such as…”
Get full text

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing by Warzecha, Claude C., Sato, Trey K., Nabet, Behnam, Hogenesch, John B., Carstens, Russ P.

“…Cell-type-specific expression of epithelial and mesenchymal isoforms of Fibroblast Growth Factor Receptor 2 (FGFR2) is achieved through tight regulation of…”
Get full text

Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition by Yang, Yueqin, Park, Juw Won, Bebee, Thomas W., Warzecha, Claude C., Guo, Yang, Shang, Xuequn, Xing, Yi, Carstens, Russ P.

“…The epithelial-to-mesenchymal transition (EMT) is an essential biological process during embryonic development that is also implicated in cancer metastasis…”
Get full text

Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms by Yang, Yueqin, Carstens, Russ P.

“…Epithelial-Splicing-Regulatory-Protein 1 (Esrp1) is a cell-type specific RNA-binding protein (RBP) that is essential for mammalian development through…”
Get full text

Multiphasic and Dynamic Changes in Alternative Splicing during Induction of Pluripotency Are Coordinated by Numerous RNA-Binding Proteins by Cieply, Benjamin, Park, Juw Won, Nakauka-Ddamba, Angela, Bebee, Thomas W., Guo, Yang, Shang, Xuequn, Lengner, Christopher J., Xing, Yi, Carstens, Russ P.

“…Alternative splicing (AS) plays a critical role in cell fate transitions, development, and disease. Recent studies have shown that AS also influences…”
Get full text

The germ cell-specific RNA binding protein RBM46 is essential for spermatogonial differentiation in mice by Peart, Natoya J, Johnson, Taylor A, Lee, Sungkyoung, Sears, Matthew J, Yang, Fang, Quesnel-Vallières, Mathieu, Feng, Huijuan, Recinos, Yocelyn, Barash, Yoseph, Zhang, Chaolin, Hermann, Brian P, Wang, P Jeremy, Geyer, Christopher B, Carstens, Russ P

“…Control over gene expression is exerted, in multiple stages of spermatogenesis, at the post-transcriptional level by RNA binding proteins (RBPs). We identify…”
Get full text

Exo70 Isoform Switching upon Epithelial-Mesenchymal Transition Mediates Cancer Cell Invasion by Lu, Hezhe, Liu, Jianglan, Liu, Shujing, Zeng, Jingwen, Ding, Deqiang, Carstens, Russ P., Cong, Yusheng, Xu, Xiaowei, Guo, Wei

“…Epithelial-mesenchymal transition (EMT) is an important developmental process hijacked by cancer cells for their dissemination. Here, we show that Exo70, a…”
Get full text

The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development by Bebee, Thomas W, Park, Juw Won, Sheridan, Katherine I, Warzecha, Claude C, Cieply, Benjamin W, Rohacek, Alex M, Xing, Yi, Carstens, Russ P

“…Tissue- and cell-type-specific regulators of alternative splicing (AS) are essential components of posttranscriptional gene regulation, necessary for normal…”
Get full text

The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events by Warzecha, Claude C., Shen, Shihao, Xing, Yi, Carstens, Russ P.

“…Cell-type and tissue-specific alternative splicing events are regulated by combinatorial control involving both abundant RNA binding proteins as well as those…”
Get full text

Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors by Di Modugno, Francesca, Iapicca, Pierluigi, Boudreau, Aaron, Mottolese, Marcella, Terrenato, Irene, Perracchio, Letizia, Carstens, Russ P, Santoni, Angela, Bissell, Mina J, Nisticò, Paola

“…Human mena (hMENA), a member of the actin cytoskeleton regulators Ena/VASP, is overexpressed in high-risk preneoplastic lesions and in primary breast tumors…”
Get full text

Networking in an Alternative Splicing World by Carstens, Russ P.

“…Using Caenorhabditis elegans as a model system, Norris et al. (2014) define complex combinatorial regulation of alternative splicing at single-neuron…”
Get full text

The RNA binding protein RBM38 (RNPC1) regulates splicing during late erythroid differentiation by Heinicke, Laurie A, Nabet, Behnam, Shen, Shihao, Jiang, Peng, van Zalen, Sebastiaan, Cieply, Benjamin, Russell, J Eric, Xing, Yi, Carstens, Russ P

“…Alternative pre-mRNA splicing is a prevalent mechanism in mammals that promotes proteomic diversity, including expression of cell-type specific protein…”
Get full text

Heterogeneous Ribonucleoprotein M Is a Splicing Regulatory Protein That Can Enhance or Silence Splicing of Alternatively Spliced Exons by Hovhannisyan, Ruben H., Carstens, Russ P.

“…Splicing of fibroblast growth factor receptor 2 (FGFR2) alternative exons IIIb and IIIc is regulated by the auxiliary RNA cis-element ISE/ISS-3 that promotes…”
Get full text

MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data by Shen, Shihao, Park, Juw Won, Huang, Jian, Dittmar, Kimberly A., Lu, Zhi-xiang, Zhou, Qing, Carstens, Russ P., Xing, Yi

Get full text

The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function by Peart, Natoya J., Hwang, Jae Yeon, Quesnel-Vallières, Mathieu, Sears, Matthew J., Yang, Yuequin, Stoilov, Peter, Barash, Yoseph, Park, Juw Won, Lynch, Kristen W., Carstens, Russ P.

“…The epithelial splicing regulatory proteins, ESRP1 and ESRP2, are essential for mammalian development through the regulation of a global program of alternative…”
Get full text

Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis by Caetano da Silva, Caroline, Macias Trevino, Claudio, Mitchell, Jason, Murali, Hemma, Tsimbal, Casey, Dalessandro, Eileen, Carroll, Shannon H., Kochhar, Simren, Curtis, Sarah W., Cheng, Ching Hsun Eric, Wang, Feng, Kutschera, Eric, Carstens, Russ P., Xing, Yi, Wang, Kai, Leslie, Elizabeth J., Liao, Eric C.

“…Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2 regulate craniofacial morphogenesis and…”
Get full text

MADS+: discovery of differential splicing events from Affymetrix exon junction array data by Shen, Shihao, Warzecha, Claude C., Carstens, Russ P., Xing, Yi

“…Motivation: The Affymetrix Human Exon Junction Array is a newly designed high-density exon-sensitive microarray for global analysis of alternative splicing…”
Get full text

MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data by Shen, Shihao, Park, Juw Won, Huang, Jian, Dittmar, Kimberly A, Lu, Zhi-xiang, Zhou, Qing, Carstens, Russ P, Xing, Yi

“…Ultra-deep RNA sequencing has become a powerful approach for genome-wide analysis of pre-mRNA alternative splicing. We develop MATS (multivariate analysis of…”
Get full text

Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs by Nabet, Behnam, Tsai, Arthur, Tobias, John W, Carstens, Russ P

“…The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body…”
Get full text