Search Results - "Carsten Stephan"

Discordant Health Implications and Molecular Mechanisms of Vitamin D in Clinical and Preclinical Studies of Prostate Cancer: A Critical Appraisal of the Literature Data by Fendler, Annika, Stephan, Carsten, Ralla, Bernhard, Jung, Klaus

“…Clinical and preclinical studies have provided conflicting data on the postulated beneficial effects of vitamin D in patients with prostate cancer. In this…”
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Prostate-specific antigen and other serum and urine markers in prostate cancer by Stephan, Carsten, Ralla, Bernhard, Jung, Klaus

“…Prostate-specific antigen (PSA) is one of the most widely used tumor markers, and strongly correlates with the risk of harboring from prostate cancer (PCa)…”
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The Immune Checkpoint Regulator PD-L1 Is Highly Expressed in Aggressive Primary Prostate Cancer by Gevensleben, Heidrun, Dietrich, Dimo, Golletz, Carsten, Steiner, Susanne, Jung, Maria, Thiesler, Thore, Majores, Michael, Stein, Johannes, Uhl, Barbara, Müller, Stefan, Ellinger, Jörg, Stephan, Carsten, Jung, Klaus, Brossart, Peter, Kristiansen, Glen

“…Therapies targeting the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway promote anti-tumor immunity and have shown promising results in…”
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Robust MicroRNA Stability in Degraded RNA Preparations from Human Tissue and Cell Samples by JUNG, Monika, SCHAEFER, Annika, STEINER, Isabel, KEMPKENSTEFFEN, Carsten, STEPHAN, Carsten, ERBERSDOBLER, Andreas, JUNG, Klaus

“…RNA integrity is the essential factor that determines the accuracy of mRNA transcript measurements obtained with quantitative real-time reverse-transcription…”
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Integrated microRNA and mRNA Signature Associated with the Transition from the Locally Confined to the Metastasized Clear Cell Renal Cell Carcinoma Exemplified by miR-146-5p by Wotschofsky, Zofia, Gummlich, Linda, Liep, Julia, Stephan, Carsten, Kilic, Ergin, Jung, Klaus, Billaud, Jean-Noel, Meyer, Hellmuth-Alexander

“…MicroRNAs (miRNAs) regulate gene expression by interfering translation or stability of target transcripts. This interplay between miRNA and their mRNA has been…”
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Multicenter evaluation of [-2]proprostate-specific antigen and the prostate health index for detecting prostate cancer by Stephan, Carsten, Vincendeau, Sébastien, Houlgatte, Alain, Cammann, Henning, Jung, Klaus, Semjonow, Axel

“…Total prostate-specific antigen (tPSA) is flawed for prostate cancer (PCa) detection. [-2]proprostate-specific antigen (p2PSA), a molecular isoform of free PSA…”
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Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma by Schaefer, Annika, Jung, Monika, Mollenkopf, Hans‐Joachim, Wagner, Ina, Stephan, Carsten, Jentzmik, Florian, Miller, Kurt, Lein, Michael, Kristiansen, Glen, Jung, Klaus

“…This study aimed to investigate the microRNA (miRNA) profile in prostate carcinoma tissue by microarray analysis and RT‐qPCR, to clarify associations of miRNA…”
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Validation of Prostate Imaging Reporting and Data System Version 2 for the Detection of Prostate Cancer by Hofbauer, Sebastian L., Maxeiner, Andreas, Kittner, Beatrice, Heckmann, Robin, Reimann, Maximillian, Wiemer, Laura, Asbach, Patrick, Haas, Matthias, Penzkofer, Tobias, Stephan, Carsten, Friedersdorff, Frank, Fuller, Florian, Miller, Kurt, Cash, Hannes

“…The second version of the PI-RADS™ (Prostate Imaging Reporting and Data System) was introduced in 2015 to standardize the interpretation and reporting of…”
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Advances in Biomarkers for PCa Diagnostics and Prognostics-A Way towards Personalized Medicine by Stephan, Carsten, Jung, Klaus

“…Prostate cancer (PCa) is, with an estimated number of 161,360 cases and 26,730 deaths in 2017, the most common malignancy in the USA [...]…”
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MicroRNAs as Regulators of Signal Transduction in Urological Tumors by FENDLER, Annika, STEPHAN, Carsten, YOUSEF, George M, JUNG, Klaus

“…MicroRNAs (miRNAs) are short noncoding RNAs that have been shown to play pivotal roles in carcinogenesis. In the past decade, miRNAs have been the focus of…”
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Prostate cancer detection on transrectal ultrasonography‐guided random biopsy despite negative real‐time magnetic resonance imaging/ultrasonography fusion‐guided targeted biopsy: reasons for targeted biopsy failure by Cash, Hannes, Günzel, Karsten, Maxeiner, Andreas, Stephan, Carsten, Fischer, Thomas, Durmus, Tahir, Miller, Kurt, Asbach, Patrick, Haas, Matthias, Kempkensteffen, Carsten

“…Objective To examine the value of additional transrectal ultrasonography (TRUS)‐guided random biopsy (RB) in patients with negative magnetic resonance imaging…”
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Sensitivity of HOXB13 as a Diagnostic Immunohistochemical Marker of Prostatic Origin in Prostate Cancer Metastases: Comparison to PSA, Prostein, Androgen Receptor, ERG, NKX3.1, PSAP, and PSMA by Kristiansen, Ilka, Stephan, Carsten, Jung, Klaus, Dietel, Manfred, Rieger, Anja, Tolkach, Yuri, Kristiansen, Glen

“…Determining the origin of metastases is an important task of pathologists to allow for the initiation of a tumor-specific therapy. Recently, homeobox protein…”
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The antiapoptotic function of miR-96 in prostate cancer by inhibition of FOXO1 by Fendler, Annika, Jung, Monika, Stephan, Carsten, Erbersdobler, Andreas, Jung, Klaus, Yousef, George M

“…microRNAs (miRNAs) are small molecules that regulate gene expression posttranscriptionally. In a previous study, we identified miR-96 to be upregulated in…”
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National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers by Sturgeon, Catharine M, Duffy, Michael J, Stenman, Ulf-Hakan, Lilja, Hans, Brunner, Nils, Chan, Daniel W, Babaian, Richard, Bast, Robert C., Jr, Dowell, Barry, Esteva, Francisco J, Haglund, Caj, Harbeck, Nadia, Hayes, Daniel F, Holten-Andersen, Mads, Klee, George G, Lamerz, Rolf, Looijenga, Leendert H, Molina, Rafael, Nielsen, Hans Jorgen, Rittenhouse, Harry, Semjonow, Axel, Shih, Ie-Ming, Sibley, Paul, Soletormos, Gyorgy, Stephan, Carsten, Sokoll, Lori, Hoffman, Barry R, Diamandis, Eleftherios P

“…Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been…”
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KDM5C Is Overexpressed in Prostate Cancer and Is a Prognostic Marker for Prostate-Specific Antigen-Relapse Following Radical Prostatectomy by Stein, Johannes, Majores, Michael, Rohde, Magdalena, Lim, Soyoung, Schneider, Simon, Krappe, Eliana, Ellinger, Jörg, Dietel, Manfred, Stephan, Carsten, Jung, Klaus, Perner, Sven, Kristiansen, Glen, Kirfel, Jutta

“…Currently, few prognostic factors are available to predict the emergence of castration-resistant prostate cancer and no curative options are available…”
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Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer by Fritzsche, Florian R, Weichert, Wilko, Röske, Annika, Gekeler, Volker, Beckers, Thomas, Stephan, Carsten, Jung, Klaus, Scholman, Katharina, Denkert, Carsten, Dietel, Manfred, Kristiansen, Glen

“…Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The…”
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MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy by Jung, Monika, Mollenkopf, Hans‐Joachim, Grimm, Christina, Wagner, Ina, Albrecht, Marco, Waller, Tobias, Pilarsky, Christian, Johannsen, Manfred, Stephan, Carsten, Lehrach, Hans, Nietfeld, Wilfried, Rudel, Thomas, Jung, Klaus, Kristiansen, Glen

“…MicroRNAs are short single‐stranded RNAs that are associated with gene regulation at the transcriptional and translational level. Changes in their expression…”
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UBC ® Rapid Test-A Urinary Point-of-Care (POC) Assay for Diagnosis of Bladder Cancer with a focus on Non-Muscle Invasive High-Grade Tumors: Results of a Multicenter-Study by Ecke, Thorsten H, Weiß, Sarah, Stephan, Carsten, Hallmann, Steffen, Arndt, Christian, Barski, Dimitri, Otto, Thomas, Gerullis, Holger

“…UBC Test measures soluble fragments of cytokeratins 8 and 18 in urine. We present results of a multicenter study using an updated version of UBC Test in…”
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Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors by Rochow, Hannah, Jung, Monika, Weickmann, Sabine, Ralla, Bernhard, Stephan, Carsten, Elezkurtaj, Sefer, Kilic, Ergin, Zhao, Zhongwei, Jung, Klaus, Fendler, Annika, Franz, Antonia

“…As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate cancer (PCa). Using an integrative approach, we aimed to evaluate the…”
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A Novel Predictor Tool of Biochemical Recurrence after Radical Prostatectomy Based on a Five-MicroRNA Tissue Signature by Zhao, Zhongwei, Weickmann, Sabine, Jung, Monika, Lein, Michael, Kilic, Ergin, Stephan, Carsten, Erbersdobler, Andreas, Fendler, Annika, Jung, Klaus

“…Within five to ten years after radical prostatectomy (RP), approximately 15–34% of prostate cancer (PCa) patients experience biochemical recurrence (BCR),…”
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