Vitamin D status is associated with muscle strength and quality of life in patients with COPD: a seasonal prospective observation study

Owing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients. This study aimed to investigate seasonal changes in vitamin D status and any associated changes in f...

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Bibliographic Details
Published in:	International journal of chronic obstructive pulmonary disease Vol. 13; pp. 2613 - 2622
Main Authors:	Carson, Emma L, Pourshahidi, L Kirsty, Madigan, Sharon M, Baldrick, Francina R, Kelly, Martin G, Laird, Eamon, Healy, Martin, Strain, J J, Mulhern, Maria S
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-01-2018 Dove Medical Press Ltd Dove Medical Press
Subjects:	25(OH)D Aged Body mass index Care and treatment Chromatography Chronic obstructive lung disease Chronic obstructive pulmonary disease COPD Dietary Supplements Female Hand Strength Humans Infections Ireland Lifestyles Liquid chromatography Male Mass spectrometry Mortality Muscle Strength Older people Original Research Patients Prospective Studies Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology Quality of Life Questionnaires Retirement benefits Sarcopenia seasonal Seasons Smoking Spectroscopy Vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood Vitamin deficiency Vitamins Vitamins - administration & dosage Ireland United Kingdom > UK Northern Ireland United States > US Germany muscle strength 25(OH)D quality of life seasonal vitamin D COPD
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Summary:	Owing to hospitalization, reduced functional capacity and consequently, less sunlight exposure, suboptimal vitamin D status (25-hydroxyvitamin D [25(OH)D]⩽50 nmol/L) is prevalent among COPD patients. This study aimed to investigate seasonal changes in vitamin D status and any associated changes in fat-free mass (FFM), muscle strength and quality of life (QoL) in COPD patients. COPD patients living in Northern Ireland (n=51) completed study visits at the end of winter (March/April) and at the end of summer (September/October), corresponding to the nadir and peak of vitamin D status, respectively. At both time points, serum concentration of 25(OH)D was quantified by liquid chromatography-tandem mass spectrometry, FFM (kg) was measured using bioelectrical impedance and muscle strength (kg) was measured using handgrip dynamometry. QoL was assessed using the validated St George's Respiratory Questionnaire. Mean±SD 25(OH)D concentration was significantly higher at the end of summer compared to the end of winter (52.5±30.5 nmol/L vs 33.7±28.4 nmol/L, <0.001); and house- bound patients had significantly lower 25(OH)D concentration compared to nonhousebound patients at the end of summer (42.9±4.2 vs 57.2±9.9 nmol/L; ⩽0.001). Muscle strength (at both time points) and QoL (end of summer only) were positively predicted by 25(OH)D concentration, independent of age, sex and smoking status. This study highlights the need for health policies to include a recommendation for year-round vitamin D supplementation in housebound COPD patients, and wintertime supplementation in nonhousebound patients, to maintain optimal 25(OH)D concentrations to protect musculoskeletal health. Furthermore, an optimal vitamin D status may have potential benefits for QoL in these patients.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1178-2005 1176-9106 1178-2005
DOI:	10.2147/COPD.S166919