Search Results - "Carruthers, Nicholas J"

Activation of Ca2+ transport in cardiac microsomes enriches functional sets of ER and SR proteins by Cala, Steven E., Carruthers, Nicholas J., Stemmer, Paul M., Chen, Zhenhui, Chen, Xuequn

“…The importance of sarcoplasmic reticulum (SR) Ca 2+ -handling in heart has led to detailed understanding of Ca 2+ -release and re-uptake protein complexes,…”
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The human type 2 diabetes-specific visceral adipose tissue proteome and transcriptome in obesity by Carruthers, Nicholas J., Strieder-Barboza, Clarissa, Caruso, Joseph A., Flesher, Carmen G., Baker, Nicki A., Kerk, Samuel A., Ky, Alexander, Ehlers, Anne P., Varban, Oliver A., Lyssiotis, Costas A., Lumeng, Carey N., Stemmer, Paul M., O’Rourke, Robert W.

“…Dysfunctional visceral adipose tissue (VAT) in obesity is associated with type 2 diabetes (DM) but underlying mechanisms remain unclear. Our objective in this…”
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The predictive performance of short-linear motif features in the prediction of calmodulin-binding proteins by Li, Yixun, Maleki, Mina, Carruthers, Nicholas J, Stemmer, Paul M, Ngom, Alioune, Rueda, Luis

“…The prediction of calmodulin-binding (CaM-binding) proteins plays a very important role in the fields of biology and biochemistry, because the calmodulin…”
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Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data by Burton, Jordan B, Carruthers, Nicholas J, Hou, Zhanjun, Matherly, Larry H, Stemmer, Paul M

“…Localization of organelle proteins by isotope tagging (LOPIT) maps are a coordinate-directed representation of proteome data that can aid in biological…”
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Global Signaling Profiling in a Human Model of Tumorigenic Progression Indicates a Role for Alternative RNA Splicing in Cellular Reprogramming by Caruso, Joseph A, Carruthers, Nicholas J, Thibodeau, Bryan, Geddes, Timothy J, Dombkowski, Alan A, Stemmer, Paul M

“…Intracellular signaling is controlled to a large extent by the phosphorylation status of proteins. To determine how human breast cells can be reprogrammed…”
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Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells by Thakur, Chitra, Qiu, Yiran, Zhang, Qian, Carruthers, Nicholas J., Yu, Miaomiao, Bi, Zhuoyue, Fu, Yao, Wadgaonkar, Priya, Almutairy, Bandar, Seno, Akimasa, Stemmer, Paul M., Chen, Fei

“…In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human…”
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Extracellular vesicles from retinal pigment epithelial cells expressing R345W‐Fibulin‐3 induce epithelial‐mesenchymal transition in recipient cells by Zhou, Mi, Zhao, Yuanjun, Weber, Sarah R., Gates, Christopher, Carruthers, Nicholas J., Chen, Han, Liu, Xiaoming, Wang, Hong‐Gang, Ford, Michael, Swulius, Matthew T., Barber, Alistair J., Grillo, Stephanie L., Sundstrom, Jeffrey M.

“…Abstract We have shown previously that expression of R345W‐Fibulin‐3 induces epithelial‐mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells…”
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Depletion of Mdig Changes Proteomic Profiling in Triple Negative Breast Cancer Cells by Thakur, Chitra, Carruthers, Nicholas J, Zhang, Qian, Xu, Liping, Fu, Yao, Bi, Zhuoyue, Qiu, Yiran, Zhang, Wenxuan, Wadgaonkar, Priya, Almutairy, Bandar, Guo, Chunna, Stemmer, Paul M, Chen, Fei

“…Triple-negative breast cancers are highly aggressive with an overall poor prognosis and limited therapeutic options. We had previously investigated the role of…”
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Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa by Carruthers, Nicholas J, McClellan, Sharon A, Somayajulu, Mallika, Pitchaikannu, Ahalya, Bessert, Denise, Peng, Xudong, Huitsing, Kylie, Stemmer, Paul M, Hazlett, Linda D

“…The effects of glycyrrhizin (GLY) on multi-drug resistant (MDR) systemic (MDR9) vs. ocular (B1045) clinical isolates were determined. Proteomes of each isolate…”
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Enriching extracellular vesicles for mass spectrometry by Burton, Jordan B., Carruthers, Nicholas J., Stemmer, Paul M.

“…Extracellular vesicles from plasma, other body fluids and cell culture media hold great promise in the search for biomarkers. Exosomes in particular, the…”
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Proteomic Characterization of Phagosomal Membrane Microdomains During Phagolysosome Biogenesis and Evolution by Goyette, Guillaume, Boulais, Jonathan, Carruthers, Nicholas J., Landry, Christian R., Jutras, Isabelle, Duclos, Sophie, Dermine, Jean-François, Michnick, Stephen W., LaBoissière, Sylvie, Lajoie, Gilles, Barreiro, Luis, Thibault, Pierre, Desjardins, Michel

“…After their formation at the cell surface, phagosomes become fully functional through a complex maturation process involving sequential interactions with…”
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Protein Mobility Shifts Contribute to Gel Electrophoresis Liquid Chromatography Analysis by Carruthers, Nicholas J, Parker, Graham C, Gratsch, Theresa, Caruso, Joseph A, Stemmer, Paul M

“…Profiling of cellular and subcellular proteomes by liquid chromatography with tandem mass spectrometry (MS) after fractionation by SDS-PAGE is referred to as…”
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CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT by Gonzalez, Maria E, Brophy, Bryce, Eido, Ahmad, Leonetti, Adele E, Djomehri, Sabra I, Augimeri, Giuseppina, Carruthers, Nicholas J, Cavalcante, Raymond G, Giordano, Francesca, Andò, Sebastiano, Nesvizhskii, Alexey I, Fearon, Eric R, Kleer, Celina G

“…Metaplastic breast carcinomas (mBrCA) are a highly aggressive subtype of triple-negative breast cancer with histologic evidence of epithelial-to-mesenchymal…”
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Single Amino Acid Variant Discovery in Small Numbers of Cells by Tan, Zhijing, Yi, Xinpei, Carruthers, Nicholas J, Stemmer, Paul M, Lubman, David M

“…We have performed deep proteomic profiling down to as few as 9 Panc-1 cells using sample fractionation, TMT multiplexing, and a carrier/reference strategy. Off…”
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4‐Hydroxy‐2‐nonenal attenuates 8‐oxoguanine DNA glycosylase 1 activity by Pan, Guodong, Deshpande, Mandar, Pang, Haiyan, Stemmer, Paul M., Carruthers, Nicholas J., Shearn, Colin T., Backos, Donald S., Palaniyandi, Suresh S.

“…Elevated cellular oxidative stress and oxidative DNA damage are key contributors to impaired cardiac function in diabetes. During chronic inflammation,…”
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Acetoacetate induces CYP2E1 protein and suppresses CYP2E1 mRNA in primary cultured rat hepatocytes by Abdelmegeed, Mohamed A, Carruthers, Nicholas J, Woodcroft, Kimberley J, Kim, Sang K, Novak, Raymond F

“…The ketone body acetoacetate (AA) in the absence of insulin or in the presence of diabetic insulin levels decreases CYP2E1 mRNA expression in a concentration-…”
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The anti-MRSA compound 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) inhibits protein synthesis in Staphylococcus aureus by Carruthers, Nicholas J., Stemmer, Paul M., Media, Joe, Swartz, Ken, Wang, Xiaojuan, Aube, Nicholas, Hamann, Mark T., Valeriote, Frederick, Shaw, Jiajiu

“…Methicillin-resistant S aureus (MRSA) contributes to patient mortality and extended hospital stays. 3-O-alpha-L-(2″,3″-di-p-coumaroyl)rhamnoside (KCR) is a…”
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Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs by Dombkowski, Alan A, Batista, Carlos E, Cukovic, Daniela, Carruthers, Nicholas J, Ranganathan, Ramya, Shukla, Upasana, Stemmer, Paul M, Chugani, Harry T, Chugani, Diane C

“…Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by mutations in the TSC1 and TSC2 genes. Over 80% of TSC patients are affected by…”
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Urine proteomic profiling in patients with nephrolithiasis and cystinuria by Kovacevic, Larisa, Caruso, Joseph A., Lu, Hong, Kovacevic, Natalija, Lakshmanan, Yegappan, Carruthers, Nicholas J., Goldfarb, David S.

“…Purpose The purpose of the study was to assess the differences in the concentration and function of urinary proteins between patients with cystine stones (CYS)…”
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Methionine Oxidation in the Calmodulin-Binding Domain of Calcineurin Disrupts Calmodulin Binding and Calcineurin Activation by Carruthers, Nicholas J, Stemmer, Paul M

“…Calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase important in cellular actions resulting in memory formation, cardiac hypertrophy, and T-cell…”
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