Search Results - "Carroll, Robert J."

R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment by Carroll, Robert J, Bastarache, Lisa, Denny, Joshua C

“…Phenome-wide association studies (PheWAS) have been used to replicate known genetic associations and discover new phenotype associations for genetic variants…”
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A gene-based association method for mapping traits using reference transcriptome data by Gamazon, Eric R, Wheeler, Heather E, Shah, Kaanan P, Mozaffari, Sahar V, Aquino-Michaels, Keston, Carroll, Robert J, Eyler, Anne E, Denny, Joshua C, Nicolae, Dan L, Cox, Nancy J, Im, Hae Kyung

“…Hae Kyung Im and colleagues report a method for predicting gene expression perturbations from genotype data after training on reference transcriptome data…”
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Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenome-wide association studies in the electronic health record by Wei, Wei-Qi, Bastarache, Lisa A, Carroll, Robert J, Marlo, Joy E, Osterman, Travis J, Gamazon, Eric R, Cox, Nancy J, Roden, Dan M, Denny, Joshua C

“…To compare three groupings of Electronic Health Record (EHR) billing codes for their ability to represent clinically meaningful phenotypes and to replicate…”
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Extracellular Vimentin as a Target Against SARS‐CoV‐2 Host Cell Invasion by Suprewicz, Łukasz, Swoger, Maxx, Gupta, Sarthak, Piktel, Ewelina, Byfield, Fitzroy J., Iwamoto, Daniel V., Germann, Danielle, Reszeć, Joanna, Marcińczyk, Natalia, Carroll, Robert J., Janmey, Paul A., Schwarz, J. M., Bucki, Robert, Patteson, Alison E.

“…Infection of human cells by pathogens, including SARS‐CoV‐2, typically proceeds by cell surface binding to a crucial receptor. The primary receptor for…”
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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups by Dikilitas, Ozan, Schaid, Daniel J., Kosel, Matthew L., Carroll, Robert J., Chute, Christopher G., Denny, Joshua C., Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P., Lee, Ming Ta Michael, Pacheco, Jennifer A., Rowley, Robb, Sleiman, Patrick M., Stein, C. Michael, Sturm, Amy C., Wei, Wei-Qi, Wiesner, Georgia L., Williams, Marc S., Zhang, Yanfei, Manolio, Teri A., Kullo, Iftikhar J.

“…Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African…”
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Using item response theory to improve measurement in strategic management research: An application to corporate social responsibility by Carroll, Robert J., Primo, David M., Richter, Brian K.

“…Research summary: This article uses item response theory (IRT) to advance strategic management research, focusing on an application to corporate social…”
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Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus by Barnado, April, Carroll, Robert J, Casey, Carolyn, Wheless, Lee, Denny, Joshua C, Crofford, Leslie J

“…African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not…”
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Antibacterial and Cytocompatible pH-Responsive Peptide Hydrogel by Edirisinghe, Dona Imanga Upamadi, D'Souza, Areetha, Ramezani, Maryam, Carroll, Robert J, Chicón, Quenten, Muenzel, Cheyene L, Soule, Jonathan, Monroe, Mary Beth Browning, Patteson, Alison E, Makhlynets, Olga V

“…A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the…”
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Workshop proceedings: GWAS summary statistics standards and sharing by MacArthur, Jacqueline A.L., Buniello, Annalisa, Harris, Laura W., Hayhurst, James, McMahon, Aoife, Sollis, Elliot, Cerezo, Maria, Hall, Peggy, Lewis, Elizabeth, Whetzel, Patricia L., Bahcall, Orli G., Barroso, Inês, Carroll, Robert J., Inouye, Michael, Manolio, Teri A., Rich, Stephen S., Hindorff, Lucia A., Wiley, Ken, Parkinson, Helen

“…Genome-wide association studies (GWASs) have enabled robust mapping of complex traits in humans. The open sharing of GWAS summary statistics (SumStats) is…”
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Racial disparity in taxane‐induced neutropenia among cancer patients by Zheng, Neil S., Wang, Fei, Agarwal, Rajiv, Carroll, Robert J., Wei, Wei‐Qi, Berlin, Jordan, Shu, Xiao‐Ou

“…Background Large interindividual variations have been reported in chemotherapy‐induced toxicities. Little is known whether racial disparities exist in…”
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Under-specification as the source of ambiguity and vagueness in narrative phenotype algorithm definitions by Yu, Jingzhi, Pacheco, Jennifer A, Ghosh, Anika S, Luo, Yuan, Weng, Chunhua, Shang, Ning, Benoit, Barbara, Carrell, David S, Carroll, Robert J, Dikilitas, Ozan, Freimuth, Robert R, Gainer, Vivian S, Hakonarson, Hakon, Hripcsak, George, Kullo, Iftikhar J, Mentch, Frank, Murphy, Shawn N, Peissig, Peggy L, Ramirez, Andrea H, Walton, Nephi, Wei, Wei-Qi, Rasmussen, Luke V

“…Currently, one of the commonly used methods for disseminating electronic health record (EHR)-based phenotype algorithms is providing a narrative description of…”
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Palladium-Catalyzed N-Demethylation/N-Acylation of Some Morphine and Tropane Alkaloids by Carroll, Robert J., Leisch, Hannes, Scocchera, Eric, Hudlicky, Tomas, Cox, D. Phillip

“…Hydrocodone was converted to various N‐acyl derivatives via a one‐pot N‐demethylation/N‐acylation protocol catalyzed by palladium(II). The procedure has also…”
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Prediction, Proxies, and Power by Carroll, Robert J., Kenkel, Brenton

“…Many enduring questions in international relations theory focus on power relations, so it is important that scholars have a good measure of relative power. The…”
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Inference-based correction of multi-site height and weight measurement data in the All of Us research program by Khan, Mirza S, Carroll, Robert J

“…Abstract Objective Measurement and data entry of height and weight values are error prone. Aggregation of medical record data from multiple sites creates new…”
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Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis by Ishigaki, Kazuyoshi, Sakaue, Saori, Terao, Chikashi, Luo, Yang, Sonehara, Kyuto, Yamaguchi, Kensuke, Amariuta, Tiffany, Too, Chun Lai, Laufer, Vincent A., Scott, Ian C., Viatte, Sebastien, Takahashi, Meiko, Ohmura, Koichiro, Murasawa, Akira, Hashimoto, Motomu, Ito, Hiromu, Hammoudeh, Mohammed, Emadi, Samar Al, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad W., Wu, Xin, Lin, Li, Li, Ting, Plant, Darren, Barton, Anne, Orozco, Gisela, Verstappen, Suzanne M. M., Bowes, John, MacGregor, Alexander J., Honda, Suguru, Koido, Masaru, Tomizuka, Kohei, Kamatani, Yoichiro, Tanaka, Hiroaki, Tanaka, Eiichi, Suzuki, Akari, Maeda, Yuichi, Yamamoto, Kenichi, Miyawaki, Satoru, Xie, Gang, Zhang, Jinyi, Amos, Christopher I., Keystone, Edward, Wolbink, Gertjan, van der Horst-Bruinsma, Irene, Cui, Jing, Liao, Katherine P., Carroll, Robert J., Lee, Hye-Soon, Bang, So-Young, Siminovitch, Katherine A., de Vries, Niek, Alfredsson, Lars, Rantapää-Dahlqvist, Solbritt, Karlson, Elizabeth W., Bae, Sang-Cheol, Kimberly, Robert P., Edberg, Jeffrey C., Mariette, Xavier, Huizinga, Tom, Dieudé, Philippe, Schneider, Matthias, Kerick, Martin, Denny, Joshua C., Matsuda, Koichi, Matsuo, Keitaro, Mimori, Tsuneyo, Matsuda, Fumihiko, Fujio, Keishi, Tanaka, Yoshiya, Kumanogoh, Atsushi, Traylor, Matthew, Lewis, Cathryn M., Eyre, Stephen, Xu, Huji, Saxena, Richa, Arayssi, Thurayya, Kochi, Yuta, Ikari, Katsunori, Harigai, Masayoshi, Gregersen, Peter K., Yamamoto, Kazuhiko, Louis Bridges, S., Padyukov, Leonid, Martin, Javier, Klareskog, Lars, Okada, Yukinori, Raychaudhuri, Soumya

“…Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to…”
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Comparing medical history data derived from electronic health records and survey answers in the All of Us Research Program by Sulieman, Lina, Cronin, Robert M, Carroll, Robert J, Natarajan, Karthik, Marginean, Kayla, Mapes, Brandy, Roden, Dan, Harris, Paul, Ramirez, Andrea

“…Abstract Objective A participant’s medical history is important in clinical research and can be captured from electronic health records (EHRs) and…”
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Genetics of rheumatoid arthritis contributes to biology and drug discovery by Okada, Yukinori, Wu, Di, Trynka, Gosia, Raj, Towfique, Terao, Chikashi, Ikari, Katsunori, Kochi, Yuta, Ohmura, Koichiro, Suzuki, Akari, Yoshida, Shinji, Graham, Robert R., Manoharan, Arun, Ortmann, Ward, Bhangale, Tushar, Denny, Joshua C., Carroll, Robert J., Eyler, Anne E., Greenberg, Jeffrey D., Kremer, Joel M., Pappas, Dimitrios A., Jiang, Lei, Yin, Jian, Ye, Lingying, Su, Ding-Feng, Yang, Jian, Xie, Gang, Keystone, Ed, Westra, Harm-Jan, Esko, Tõnu, Metspalu, Andres, Zhou, Xuezhong, Gupta, Namrata, Mirel, Daniel, Stahl, Eli A., Diogo, Dorothée, Cui, Jing, Liao, Katherine, Guo, Michael H., Myouzen, Keiko, Kawaguchi, Takahisa, Coenen, Marieke J. H., van Riel, Piet L. C. M., van de Laar, Mart A. F. J., Guchelaar, Henk-Jan, Huizinga, Tom W. J., Dieudé, Philippe, Mariette, Xavier, Louis Bridges Jr, S., Zhernakova, Alexandra, Toes, Rene E. M., Tak, Paul P., Miceli-Richard, Corinne, Bang, So-Young, Lee, Hye-Soon, Martin, Javier, Gonzalez-Gay, Miguel A., Rodriguez-Rodriguez, Luis, Rantapää-Dahlqvist, Solbritt, Ärlestig, Lisbeth, Choi, Hyon K., Kamatani, Yoichiro, Galan, Pilar, Lathrop, Mark, Eyre, Steve, Bowes, John, Barton, Anne, de Vries, Niek, Moreland, Larry W., Criswell, Lindsey A., Karlson, Elizabeth W., Taniguchi, Atsuo, Yamada, Ryo, Kubo, Michiaki, Liu, Jun S., Bae, Sang-Cheol, Worthington, Jane, Padyukov, Leonid, Klareskog, Lars, Gregersen, Peter K., Raychaudhuri, Soumya, Stranger, Barbara E., De Jager, Philip L., Franke, Lude, Visscher, Peter M., Brown, Matthew A., Yamanaka, Hisashi, Mimori, Tsuneyo, Takahashi, Atsushi, Xu, Huji, Behrens, Timothy W., Siminovitch, Katherine A., Momohara, Shigeki, Matsuda, Fumihiko, Yamamoto, Kazuhiko, Plenge, Robert M.

“…A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis,…”
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Developing Electronic Health Record Algorithms That Accurately Identify Patients With Systemic Lupus Erythematosus by Barnado, April, Casey, Carolyn, Carroll, Robert J., Wheless, Lee, Denny, Joshua C., Crofford, Leslie J.

“…Objective To study systemic lupus erythematosus (SLE) in the electronic health record (EHR), we must accurately identify patients with SLE. Our objective was…”
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Strategic avoidance and rulemaking procedures by Bils, Peter, Carroll, Robert J., Rothenberg, Lawrence S.

“…Informal, ‘notice-and-comment’, rulemaking is the prototypical mechanism employed by US regulators. However, agencies frequently claim their actions exempt…”
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Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data by Denny, Joshua C, Bastarache, Lisa, Ritchie, Marylyn D, Carroll, Robert J, Zink, Raquel, Mosley, Jonathan D, Field, Julie R, Pulley, Jill M, Ramirez, Andrea H, Bowton, Erica, Basford, Melissa A, Carrell, David S, Peissig, Peggy L, Kho, Abel N, Pacheco, Jennifer A, Rasmussen, Luke V, Crosslin, David R, Crane, Paul K, Pathak, Jyotishman, Bielinski, Suzette J, Pendergrass, Sarah A, Xu, Hua, Hindorff, Lucia A, Li, Rongling, Manolio, Teri A, Chute, Christopher G, Chisholm, Rex L, Larson, Eric B, Jarvik, Gail P, Brilliant, Murray H, McCarty, Catherine A, Kullo, Iftikhar J, Haines, Jonathan L, Crawford, Dana C, Masys, Daniel R, Roden, Dan M

“…When applied in large scale to electronic medical record data, the PheWAS approach replicates GWAS associations and reveals potentially new pleiotropic…”
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